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| 1 | Role of abnormal lipid metabolism in development,progression,diagnosis and therapy of pancreatic cancer显示文摘There is growing evidence that metabolic alterations play an important role in cancer development and progression.The metabolism of cancer cells is reprogrammed in order to support their rapid proliferation.Elevated fatty acid synthesis is one of the most important aberrations of cancer cell metabolism.An enhancement of fatty acids synthesis is required both for carcinogenesis and cancer cell survival,as inhibition of key lipogenic enzymes slows down the growth of tumor cells and impairs their survival.Based on the data that serum fatty acid synthase(FASN),also known as oncoantigen 519,is elevated in patients with certain types of cancer,its serum level was proposed as a marker of neoplasia.This review aims to demonstrate the changes in lipid metabolism and other metabolic processes associated with lipid metabolism in pancreatic ductal adenocarcinoma(PDAC),the most common pancreatic neoplasm,characterized by high mortality.We also addressed the influence of some oncogenic factors and tumor suppressors on pancreatic cancer cell metabolism.Additionally the review discusses the potential role of elevated lipid synthesis in diagnosis and treatment of pancreatic cancer.In particular,FASN is a viable candidate for indicator of pathologic state,marker of neoplasia,as well as,pharmacological treatment target in pancreatic cancer.Recent research showed that,in addition to lipogenesis,certain cancer cells can use fatty acids from circulation,derived from diet(chylomicrons),synthesized in liver,or released from adipose tissue for their growth.Thus,the interactions between de novo lipogenesis and uptake of fatty acids from circulation by PDAC cells require further investigation. | Julian Swierczynski Areta Hebanowska Tomasz Sledzinski | 2014 | World Journal of Gastroenterology2014，20，9： | 16 |
| 2 | Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome显示文摘Clinical studies have indicated that circulating bile acid(BA) concentrations increase following bariatric surgery, especially following malabsorptive procedures such as Roux-en-Y gastric bypasses(RYGB). Moreover, total circulating BA concentrations in patients following RYGB are positively correlated with serum glucagonlike peptide-1 concentrations and inversely correlated with postprandial glucose concentrations. Overall, these data suggest that the increased circulating BA concentrations following bariatric surgery- independently of calorie restriction and body-weight loss- could contribute, at least in part, to improvements in insulin sensitivity, incretin hormone secretion, and postprandial glycemia, leading to the remission of type-2 diabetes(T2DM). In humans, the primary and secondary BA pool size is dependent on the rate of biosynthesis and the enterohepatic circulation of BAs, as well as on the gut microbiota, which play a crucial role in BA biotransformation. Moreover, BAs and gut microbiota are closely integrated and affect each other. Thus, the alterations in bile flow that result from anatomical changes caused by bariatric surgery and changes in gutmicrobiome may influence circulating BA concentrations and could subsequently contribute to T2 DM remission following RYGB. Research data coming largely from animal and cell culture models suggest that BAs can contribute, via nuclear farnezoid X receptor(FXR) and membrane G-protein-receptor(TGR-5), to beneficial effects on glucose metabolism. It is therefore likely that FXR, TGR-5, and BAs play a similar role in glucose metabolism following bariatric surgery in humans. The objective of this review is to discuss in detail the results of published studies that show how bariatric surgery affects glucose metabolism and subsequently T2 DM remission. | Lukasz Kaska Tomasz Sledzinski Agnieszka Chomiczewska Agnieszka Dettlaff-Pokora Julian Swierczynski | 2016 | World Journal of Gastroenterology2016，22，39： | 11 |
| 3 | Effect of NCPB and VSPL on pain and quality of life in chronic pancreatitis patients显示文摘AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain. | Andrzej Basinski Tomasz Stefaniak Ad Vingerhoets Wojciech Makarewicz Lukasz Kaska Aleksander Stanek Andrzej J.Lachinski Zbigniew Sledzinski | 2005 | World Journal of Gastroenterology2005，11，32： | 10 |
| 4 | Decreased serum essential and aromatic amino acids in patients with chronic pancreatitis显示文摘AIM:To investigate the influence of chronic pancreatitis(CP) on serum concentrations of amino acids.METHODS:Thirty-five male patients with alcoholic CP and 21 healthy male subjects were examined.Serum concentrations of amino acids were assayed by ionpair high-performance liquid chromatography with mass detection.RESULTS:Serum glutamate concentration was increased in CP patients as compared to controls.In contrast,serum concentrations of glutamine,histidine,tyrosine,proline,tryptophan and threonine were significantly decreased in CP patients.A trend towards decreasing concentrations of serum lysine,alanine,methionine and valine as well as for total serum amino acids was observed.The sum of aromatic and the sum of essential amino acid concentrations were significantly lower in CP patients than in controls.CONCLUSION:CP leads to decreased serum concentrations of several amino acids,such as essential and aromatic serum amino acids,most likely due to decreased exocrine function. | Krystian Adrych Marian Smoczynski Magdalena Stojek Tomasz Sledzinski Ewa Slominska Elzbieta Goyke Ryszard Tomasz Smolenski Julian Swierczynski | 2010 | World Journal of Gastroenterology2010，16，35： | 3 |
| 5 | Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis显示文摘AIM: To examine circulating growth factor concentrations in patients with acute pancreatitis(AP) and chronic pancreatitis(CP), and walled-off pancreatic necrosis(WOPN). METHODS: Forty patients with mild AP, 40 patients with alcoholic CP, 33 patients with WOPN and 40 healthy subjects were examined. Serum concentrations of platelet derived growth factor BB(PDGF-BB), transforming growth factor β-1(TGFβ-1), chemerin and high-mobility group box chromosomal protein 1(HMBG1) were assayed by enzyme linked immunosorbent assay.RESULTS: Patients with mild AP and those with WOPN had significantly lower serum levels of PDGF-BB compared to healthy subjects(4.0 ± 0.61 ng/mL vs 6.2 ± 0.76 ng/mL, P = 0.027, and 1.60 ± 0.31 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001, respectively), while CP was associated with higher serum levels of PDGF-BB(12 ± 1.3 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001). Circulating TGFβ-1 and chemerin levels were elevated in CP patients(57 ± 3.6 ng/mL vs 39 ± 3.6 ng/mL, P < 0.001 and 73 ± 7.2 ng/mL vs 48 ± 2.3 ng/mL, P < 0.001, respectively), but not in patients with AP and WOPN. No significant changes in serum HMBG1 levels were found either in patients with AP, WOPN or CP. CONCLUSION: The serum levels of some growth factors and cytokines differ significantly in AP, WOPN and CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases. | Magdalena Stojek Krystian Adrych Lukasz Rojek Marian Smoczynski Tomasz Sledzinski Sylwia Szrok Julian Swierczynski | 2014 | World Journal of Gastroenterology2014，20，36： | 2 |
| 6 | The increase of serum chemerin concentration is mainly associated with the increase of body mass index in obese, non diabetic subjects 显示文摘 | Sledzinski T Korczynska J Hallmann A | 2013 | Endocrinol Invest2013，36，6： | 1 |
| 7 | Results of pancreaticogastrostomy after pancreaticoduodenectomy in 159 consecutive cases 显示文摘 | Sledzinski Z Kostro JZ Zadrozny D | 2008 | Pancreatology2008，8，1： | 1 |
| 8 | Decrease of serum ehemerin concentration in patients with end stage re- nal disease after successful kidney transplantation 显示文摘 | Rutkowski P Sledzinski T Zielinska H | 2012 | Regnl Pept2012，173，13： | 1 |
| 9 | Decrease of ser- um chemerin concentration in patients with end stage renal disease after successful kidney transplantation显示文摘 | Rutkowski P Sledzinski T Slezielinska H | 2012 | Regul Pept2012，173，13： | 1 |
| 10 | Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy显示文摘 | ZADROZNY D SLEDZINSKI Z | 2000 | Surg Laparosc Endosc Percutan Tech2000，10，6： | 1 |
| 11 | Metabolic and regulatoryfunction of fatty acid synthase显示文摘 | SWIERCZYNSKI J SLEDZINSKI T | 2011 | Postepy Biochemii2011，58，2： | 1 |
| 12 | Fibrogenesis in fatty liver associated with obesity and diabetes mellitus type 2显示文摘 | Jaskiewicz K Rzepko R Sledzinski Z | 2008 | Dig Dis Sci2008，53，3： | 1 |
| 13 | Decreased serum betaine concentrations in patienets after bariatrie surgey 显示文摘 | Sledzinski T Goylce E Smolenski RT | 2011 | Obes surg2011，21，10： | 1 |
| 14 | Increased Serum Resistin Concentration in Patients With Chronic Pancreatitis: Possible Cause of Pancreatic Fibrosis显示文摘 | Krystian Adrych Marian Smoczynski Tomasz Sledzinski Agnieszka Dettlaff-Pokora Elzbieta Goyke Julian Swierczynski | 2009 | Journal of Clinical Gastroenterology2009，，1： | 1 |
| 15 | Chemerin geneexpression is regulated by food restriction and food restric- tion-refeeding in rat adipose tissue but not in liver 显示文摘 | Stelmanska E Sledzinski T Turyn J | 2013 | Regul Pept2013，181，： | 1 |
| 16 | Decrease of serumchemerin concentration in patients with end stage renal disease aftersuccessful kidney transplantation 显示文摘 | Rutkowski P Sledzinski T Zielinska H | 2012 | Regulatory Peptides2012，173，13： | 1 |
| 17 | Higher 11-beta-hydroxys- teroid dehydrogenase type I gene expression in white adipose tis- sue in male than female rats 显示文摘 | Sledzinski T Mirowska A Klimek J | 2011 | Endokrynol Pol2011，62，4： | 1 |
| 18 | Increased serum chemerin concentration in patients with chronic pancreatitis显示文摘 | Krystian Adrych Magdalena Stojek Marian Smoczynski Tomasz Sledzinski Szrok-Wojtkiewicz Sylwia Julian Swierczynski | 2011 | Digestive and Liver Disease2011，，5： | 1 |
| 19 | Decrease of serum chemerin concentration in patients with end stage renal disease after successful kidney transplantation显示文摘 | Rutkowski P Sledzinski T Zielinska H | 2012 | Regul Pept2012，173，13： | 1 |
| 20 | Chemerin gene ex-pression is regulated by food restriction and food restriction-refeed-ing in rat adipose tissue but not in liver 显示文摘 | Stelmanska E Sledzinski T Turyn J | 2013 | Regul Pept2013，181，： | 1 |
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