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| 1 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 2 | Surgical versus non-sur- gical interventions for treating patellar dislocation 显示文摘 | Hing CB Smith TO Donell S | 2011 | Co- chrane Database Syst Rev2011，9，00： | 1 |
| 3 | FKF1 conveys timing information for Constans stabilization in photoperiodic flowering显示文摘 | SONG Y H SMITH R W TO B J | 2012 | Science2012，336，6084： | 1 |
| 4 | Outcomes ofmedial patellofemoral ligament reconstruction forpatellar instability: a systematic review 显示文摘 | Smith TO Walker J RussellN | 2007 | Knee Surg SportsTraumatolArthrosc2007，15，11： | 1 |
| 5 | Boothroyd C 显示文摘 | Smith CA de Lacey S Chapman M Acupuncture to im- prove live birth rates for women undergoing in vitro fertilization : a protocol for a randomized controlled trial | 2012 | Trials2012，13，： | 1 |
| 6 | Surgical versus non-surgical in- terventions for treating patellar dislocation 显示文摘 | Hing CB Smith TO Donell S | 2011 | Cochrane Database Syst Rev2011，11，00： | 1 |
| 7 | Operative versus non-opera-tive management following Rockwood gradeⅢacromioclavicularseparation:A meta-analysis of the current evidence base显示文摘 | Smith TO Chester R Pearse EO | 2011 | Journalof Orthopaedics and Traumatology2011，12，1： | 1 |
| 8 | Apoptosis is a rare event in first-trimester placental tissue显示文摘 | Smith SC Leung TN To KF | 2000 | Am J Obstet Gynecol2000，183，： | 1 |
| 9 | A meta-analysis of randomized controlled trials comparing conventional to minimally invasive approaches for repair of an Achilles tendon rupture显示文摘 | Mc Mahon SE Smith TO Hing CB | 2011 | Foot Ankle Surg2011，17，4： | 1 |
| 10 | Operative versus non- operative management following Rockwood grade III acro- mioclavicular separation: a meta-analysis of the current ev- idence base 显示文摘 | Smith TO Chester R Pearse EO | 2011 | J Orthop Traumatol2011，12，1： | 1 |
| 11 | The diagnostic accuracy of acetabular labral tears using magnetic resonance imaging and magnetic resonance arthrography:a meta-analysis显示文摘 | Smith TO Hilton G Toms AP | 2011 | Eur Radiol2011，21，4： | 1 |
| 12 | Opening or closing wedged high tibial osteotorny: a meta - analysis of elinieal and radiologieal outcomes显示文摘 | Smith TO Sexton D Mitehell P | 2011 | 18(6) :361 -3682011，18，6： | 1 |
| 13 | Increased placental apop- tosis in pregnancies complicated by preeclampsia显示文摘 | LEUNG D N SMITH S C TO K F | 2001 | Am J Obstet Gynecol2001，184，6： | 1 |
| 14 | Developmental issues in the impact of child maltreatment on later delinquency and drug use显示文摘 | Ireland TO Smith CA Thornberry TP | 2002 | Criminology2002，40，2： | 1 |
| 15 | High dynamic range characterization of the trauma patient plasma proteome显示文摘 | Liu T Qian W J Gritsenko M A Xiao W Moldawer L L Kaushal A Monroe M E Vamum S M Moore R J Purvine S O Maier R V Davis R W Tompkins R G Camp D G 2nd Smith R D and the Inflammation and the Host Response to Injury Large Scale Collaborative Research Programm | | 0，，10： | 1 |
| 16 | Surgical versus non-surgical interventions for treating patellar dislocation显示文摘 | Smith TO Donell S Song F | 2015 | Cochrane Database Syst Rev2015，2，00： | 1 |
| 17 | The clinical and radiological outcomes of the LISS plate for distal femoral fractures : a systematic review 显示文摘 | Smith TO Hedges C MacNair R | 2009 | Injury2009，40，10： | 1 |
| 18 | The impact of subacromial impingement syndrome on muscle activity patterns of the shoulder complex:a systematic review of electromyographic studies显示文摘 | Chester R Smith TO Hooper L | 2010 | BMC Musculoskelet Disord2010，11，： | 1 |
| 19 | Fixed versus mo-bile bearing unicompartmental knee replacement: Ameta-analysis 显示文摘 | Smith TO Hing CB Davies L | 2009 | Orthop Traumatol Surg Res2009，95，8： | 1 |
| 20 | Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review显示文摘 | Davis AJ Smith TO Hing CB | 2013 | Plos One2013，8，72： | 1 |
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