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| 1 | Oligomeric Procyanidins Induce Generation of Reactive Oxygen Species and Collapse of Mitochchondrial Membrane Potential in Glioblastoma Cell Lines显示文摘Objective The aim of the present study was to clarify the mechanism underlying glioma cell death upon oligomeric procyanidins (F2) exposure. Methods The cytotoxicity of F2 on U87 (human malignant glioblastoma cell line) and C6 (rat glioma cell line) cancer cells was evaluated, and changes of mitochondrial membrane potential (MMP) and production of reactive oxygen species (ROS) in drug-treated cells were monitored. Moreover, morphological changes associated with F2-induced cells death were examined. Results F2 induced a concentration-dependent increase in ROS production and decrease in MMP. Furthermore, pre-incubation with N-acetylcysteine (NAC) and rotenone (Rt), resulted in partial inhibition of F2-induced ROS generation and marked attenuation of cell death and the cytoplasmic vacuolization induced by F2. In addition, pretreatment with Rt markedly attenuated the MMP loss in F2-treated cells. However, pretreatment with NAC only markedly attenuated the MMP loss in F2-treated C6 cells. Conclusion The increase in ROS level is at least one of mechanisms associated with F2-induced glioma cell death as well as the cytoplasmic vacuolization formation that contribute to the cytotoxicity of F2 in glioma cells. | ZHANG Feng-jiao1, YANG Jing-yu1, MOU Yan-hua1, SUN Bao-shan2, WANG Ji-ming3, WANG Fang1, WU Chun-fu1 1. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Estaco Vitivinícola Nacional, Instituto National de Investigaco Agrária, Dois Portos 2565-191, Portugal 3. Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick Maryland 21702, USA | 2009 | Chinese Herbal Medicines2009，1，1： | 3 |
| 2 | Application to clinical and public health practice:a statement for health care professionals from the centers for disease control and prevention and American heart association显示文摘 | Person TA Mensah GA Alexander RW Markers of inflammation and cardiovascular disease | 2003 | Circulation2003，107，3： | 1 |
| 3 | Early long-term development of heart survivors of acute Myocardial infarction: predictive role of C-reactive protein 显示文摘 | Suleiman M Khatib R inflammation and risk of failure and mortality in Agmon Y | 2006 | J Am Coll Cardiol2006，47，5： | 1 |
| 4 | Early- experimental therapy in transgenic models of the Alzheimer-like amyloid pathology显示文摘 | Cuello AC Ferretti MT stage inflammation and Leon WC | 2010 | Neurodegener Dis2010，7，123： | 1 |
| 5 | injury : acute cerebral central inflammation 显示文摘 | Denes A Thornton P Inflammation and brain ischaemia peripheral and Brain Behav Immun 2010 Rothwell N J | 2010 | 24(5) : 7082010，24，5： | 1 |
| 6 | High dynamic range characterization of the trauma patient plasma proteome显示文摘 | Liu T Qian W J Gritsenko M A Xiao W Moldawer L L Kaushal A Monroe M E Vamum S M Moore R J Purvine S O Maier R V Davis R W Tompkins R G Camp D G 2nd Smith R D and the Inflammation and the Host Response to Injury Large Scale Collaborative Research Programm | | 0，，10： | 1 |
| 7 | Clinical studies with curcumin显示文摘 | Curcumin protects neuron against inflammation through improving Evid Based Complement Alternat Hsu CH Cheng AL | 2007 | Adv Exp Med Biol2007，595，： | 1 |
| 8 | Systemic infections cause atherosclerotic coronary arteries: clues to the triggering effect of acute infections on acute coronary syndromes 显示文摘 | Madjid M Vela D Khalili-Tabrizi exaggerated local inflammation in H | 2007 | Tex Heart Inst J2007，34，1： | 1 |
| 9 | a two edged sword the model of bronchiectasis显示文摘 | Cole PJ Inflammation | 1986 | Eur J gespir Dis1986，，： | 1 |
| 10 | Nephrol Dial Transplant显示文摘 | Santoro A Mancini E Cardiac effects of chronic inflammation in dialysis patients | 2002 | 17 (Suppl 8)2002，1015，： | 1 |
| 11 | Persistent Low-grade Inflammation and Regular Exercise显示文摘 | Inflammation P L Astrom R E Feigh M | 2010 | Front Biosci2010，2，1： | 1 |
| 12 | A review 显示文摘 | Zalewski PD Truong-Tran AQ Grosser D et aL Zinc metabolism inairway epithelium and airway inflammation : basic mechanisms andclinical targets | 2005 | Pharmacol Ther2005，105，2： | 1 |
| 13 | Chronic subclinical of the insulin resistance syndrome:the Atherosclerosis Study(IRAS)显示文摘 | Festa A D'Agostino inflammation as part Insulin Resistance R Howard G | 2000 | Circulation2000，102，1： | 1 |
| 14 | Pierce GF显示文摘 | Inflammation in nonhealing diabetic wounds: the space -time continuum does matter | 2001 | Am J Pathol2001，159，2： | 1 |
| 15 | Atherosclerosis,and coronary artery disease显示文摘 | Inflammation HG | | 0，，16： | 1 |
| 16 | Expert opinion on investigational drugs显示文摘 | Salvemini D Marino MH1 Inducible nitric oxide synthase and inflammation | 1998 | Expert Opin Investig Drugs1998，7，1： | 1 |
| 17 | BIOCHEMICAL SOCIETY TRANSACTIONS 显示文摘 | Pitchford SC Defining a role for platelets in allergic inflammation | 2007 | Biochem Soc Trans2007，35，5： | 1 |
| 18 | Cytokines promote WNT and impair the normal accumulation in 3T3-L1 preadipocytes 显示文摘 | GUSTAFSON B SMITH U signaling and inflammation differentiation and lipid | 2006 | J Biol Chem2006，281，： | 1 |
| 19 | Markers of for prediction of coronary heart disease in older adults 显示文摘 | Rodondi N Marques-Vidal P atherosclerosis and inflammation Butler J | 2010 | Am J Epidemiol2010，171，5： | 1 |
| 20 | autoimmune genesis by programmed cell death 4 显示文摘 | Hilliard A Translational inflammation Hilliard B Zheng regulation of and lymphoma S J | 2006 | J Immunol2006，177，： | 1 |
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