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| 1 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 2 | An introduction to the national human exposure assessment survey 显示文摘 | Sexton K Kleffman D Callahan M | 1995 | Expo Anal Environ Epidemiol1995，，5： | 1 |
| 3 | Comparison of modeled and observed trends in indices of daily climate extremes 显示文摘 | Kiktev D Sexton D M H Alexander L | 2003 | Journal of Climate2003，16，： | 1 |
| 4 | The impact of overactive bladder, incontinence and other lower urinary tract symptoms On quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study显示文摘 | Coyne K Sv Sexton C Cv Irwin D E et a1 | 2008 | BJU Int2008，101，11： | 1 |
| 5 | A Vibration Energy Harvesting Sensor Platform for Increased Industrial Efficiency显示文摘 | Anderson T A Sexton D W | 2006 | SPIE2006，6174，： | 1 |
| 6 | The importance of human exposure information: a need for exposure-related data bases to protect and promote public health显示文摘 | WAGENER D K SELEVAN S G SEXTON K | 1995 | Annual Review of Public Health1995，16，： | 1 |
| 7 | Development of cerium-based conversion coatings on 2024-T3 A1 alloy after rare-earth desmutting 显示文摘 | HUGHES A E GORMAN J D MILLER P R SEXTON B A PATERSON P J K TAYLOR R J | 2004 | Surface and Interface Analysis2004，36，44： | 1 |
| 8 | Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis显示文摘 | MARR K A SEXTON D J CONLON P J | 1997 | Ann Intern Med1997，127，4： | 1 |
| 9 | Eosinophilic cystitis following immediate post-resection intravesical instillation of mitomycin-C 显示文摘 | Caso J Qin D Sexton WJ | 2010 | Can J Uro12010，17，3： | 1 |
| 10 | Denial and compliance inadults with asthma显示文摘 | McGann EF Sexton D Chyun DA | 2008 | Clin Nurs Res2008，17，3： | 1 |
| 11 | Female and Male Entrepreneurs:Psychological Characteristics and Their Role in Gender-Related Discrimination 显示文摘 | SEXTON D BOWMAN N | 1990 | Journal of Business Venturing1990，5，1： | 1 |
| 12 | Survivin expression in breast carcinoma: correlation with apoptosis and prognosis 显示文摘 | NASSAR A SEXTON D COTSONIS G | 2008 | Appl Immunohistochem Mol Morphol2008，16，3： | 1 |
| 13 | Survivin expression in hepatocellular carcinoma:correlation with proliferation,prognostic parameters,and outcome显示文摘 | Fields A C Cotsonis G Sexton D | 2004 | Mod Pathol2004，17，11： | 1 |
| 14 | Strategic Entrepreneurship: Entrepreneurial Strategies for Wealth Creation 显示文摘 | Hitt M A Ireland R D Camp S M Sexton D L | 2001 | Strategic Management Journal2001，22，67： | 1 |
| 15 | Novel peptide inhibitors of angiotensin converting enzyme 2 显示文摘 | HUANG L SEXTON D J SKOGERSON K | 2003 | J Biol Chem2003，278，15： | 1 |
| 16 | Differential regulation of pregnancy associated plasma protein(PAPP)-A during pregnancy in human and mouse显示文摘 | Sexton C Byun D | 2002 | Growth Hormone and IGF Research2002，12，： | 1 |
| 17 | The concept of entrepreneurial intensity:implications for company performance显示文摘 | MORRIS M H SEXTON D L | 1996 | Journal of business research1996，36，1： | 1 |
| 18 | Survivin expression hepatocelluar carcinoma has correlation with proliferation prognostic parameters and outcome 显示文摘 | Fields AS Cotsonis G Sexton D | 2004 | Mod Pathol2004，11，： | 1 |
| 19 | Survivin expression in breast carcinoma: correlation with apoptosis and prognosis 显示文摘 | Nassar A Sexton D Cotsonis G | 2008 | Appl Imraunohistochem Mol Morphol2008，16，3： | 1 |
| 20 | Mcl-1 expression in hepatocellular carcinoma: correlation with proliferation, prog- nostic parameters, and outcome显示文摘 | FIELDS AC COTSONIS G SEXTON D et at | 2004 | Mod Pathol2004，17，11： | 1 |
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