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| 1 | Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer显示文摘Through advances in technology,the genetic basis of cancer has been investigated at the genomic level,and many fundamental questions have begun to be addressed.Among several key unresolved questions in cancer biology,the molecular basis for the link between nuclear deformation and malignancy has not been determined.Another hallmark of human cancer is aneuploidy;however,the causes and consequences of aneuploidy are unanswered and are hotly contested topics.We found that nuclear lamina proteins lamin A/C are absent in a significant fraction(38%) of human breast cancer tissues.Even in lamin A/C-positive breast cancer,lamin A/C expression is heterogeneous or aberrant(such as non-nuclear distribution) in the population of tumor cells,as determined by immunohistology and immunofluorescence microscopy.In most breast cancer cell lines,a significant fraction of the lamin A/C-negative population was observed.To determine the consequences of the loss of lamin A/C,we suppressed their expression by shRNA in noncancerous primary breast epithelial cells.Down-regulation of lamin A/C in breast epithelial cells led to morphological deformation,resembling that of cancer cells,as observed by immunofluorescence microscopy.The lamin A/C-suppressed breast epithelial cells developed aneuploidy as determined by both flow cytometry and fluorescence in situ hybridization.We conclude that the loss of nuclear envelope structural proteins lamin A/C in breast cancer underlies the two hallmarks of cancer aberrations in nuclear morphology and aneuploidy. | Callinice D. Capo-chichi Kathy Q. Cai Jennifer Smedberg Parvin Ganjei-Azar Andrew K. Godwin Xiang-Xi Xu | 2011 | Chinese Journal of Cancer2011，30，6： | 2 |
| 2 | Inci- sional hernia repair in Sweden 2002显示文摘 | Israelsson LA Smedberg S Montgomery A | 2006 | Hernia2006，10，3： | 1 |
| 3 | Crosslinking reactions in an unsaturated low density polyethylene 显示文摘 | A Smedberg T Hjertberg | 1997 | Polymer1997，38，： | 1 |
| 4 | Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro?II mesh in Lichtenstein hernioplasty显示文摘 | Sven Bringman Timo-Jaakko Heikkinen Staffan Wollert Johanna ?sterberg Sam Smedberg H?kan Granlund Stig Ramel G?ran Fell?nder Bo Anderberg | 2004 | Hernia2004，，2： | 1 |
| 5 | Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells 显示文摘 | Smith ER Cai KQ Smedberg JL | 2010 | PLoS One2010，5，2： | 1 |
| 6 | Short-term Outcomes for Open and Laparoscopic Midline Incisional Hernia Repair: A Randomized Multicenter Controlled Trial: The ProLOVE (Prospective Randomized Trial on Open Versus Laparoscopic Operation of Ventral Eventrations) Trial显示文摘 | Peder Rogmark Ulf Petersson Sven Bringman Arne Eklund Emmanuel Ezra Dan Sevonius Sam Smedberg Johanna ?sterberg Agneta Montgomery | 2013 | Annals of Surgery2013，，1： | 1 |
| 7 | Short-term results of a randomized clinical trial comparing Liehtenstein open repair with totally extraperitoneal laparoseopie inguinal hernia repair显示文摘 | EKLUND A RUDBERG C SMEDBERG S | 2006 | Br J Surg2006，93，9： | 1 |
| 8 | Two-year follow-up study of procera-ceramic fixed partial dentures 显示文摘 | Smedberg JI Ekenback J Lothigius E | 1998 | Int J Prosthodont1998，11，2： | 1 |
| 9 | New Res ults on the Halo Structure of 8B显示文摘 | Baumann T Aumann T | 1999 | Phys Lett1999，452，： | 1 |
| 10 | Effect of molecular structure and topology on network formation in peroxide crosslinked polyethylene 显示文摘 | Smedberg A Hjertberg T Gustafsson B | 2003 | Polymer2003，44，： | 1 |
| 11 | Short-term results of a randomized clinical trial comparing Lichtenstein open repair with totally extraperitoneal laparoscoplc inguinal hernia repair 显示文摘 | Eklund A Rudberg C Smedberg S | 2006 | Br J Surg2006，93，9： | 1 |
| 12 | Risk factors for complications in groin hernia surgery: a national register study 显示文摘 | Lundstrom KJ Sandblom G smedberg S ct al | 2012 | Ann Surg2012，255，4： | 1 |
| 13 | A reduction of Cox-2 gene dosage counters the menopausal ovarian morphological aging and tumor phenotype in Wv mice 显示文摘 | Yang WL Cai KQ Smedberg JL | 2007 | Am J Pathol2007，170，4： | 1 |
| 14 | European Hernia Society guidelines on the treatment of inguinal hernia in adult patients显示文摘 | M. P. Simons T. Aufenacker M. Bay-Nielsen J. L. Bouillot G. Campanelli J. Conze D. Lange R. Fortelny T. Heikkinen A. Kingsnorth J. Kukleta S. Morales-Conde P. Nordin V. Schumpelick S. Smedberg M. Smietanski G. Weber M. Miserez | 2009 | Hernia2009，，4： | 1 |
| 15 | Risk factors for complications in groin hernia surgery: a national register study 显示文摘 | Lundstrom K J Sandblom G Smedberg S | 2012 | Ann Surg2012，255，4： | 1 |
| 16 | European Hernia Society guidelines on the treatment of inguinal hernia in adult patients显示文摘 | M. P. Simons T. Aufenacker M. Bay-Nielsen J. L. Bouillot G. Campanelli J. Conze D. Lange R. Fortelny T. Heikkinen A. Kingsnorth J. Kukleta S. Morales-Conde P. Nordin V. Schumpelick S. Smedberg M. Smietanski G. Weber M. Miserez | 2009 | Hernia2009，，4： | 1 |
| 17 | Two-year follow-up study of Procera-ceramic fixed partial dentures显示文摘 | Smedberg JI Ekenback J Lothigius E et at | 1998 | Int J Prosthodont1998，11，2： | 1 |
| 18 | Short-term results of a randomized clinical trial comparing Lichtenstein open repair with totally extraperitoneal laparoscopic inguinal hernia repair 显示文摘 | Eklund A Rudberg C Smedberg S | 2006 | Br J Surg2006，93，9： | 1 |
| 19 | Short-term results of a randomized clinical trial comparing Liehtenstein open repair with totally extraperitaneal laparoseopie inguinal hernia repair显示文摘 | EKLUND A RUDBERG C SMEDBERG S | 2006 | Br J Surg2006，93，9： | 1 |
| 20 | The role of degassing in XLPE cable manufacture显示文摘 | Andrews T Hampton R N Smedberg A | 2006 | IEEE Electrical Insulation Magazine2006，22，6： | 1 |
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