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| 1 | 核纤层蛋白家族在恶性肿瘤中的研究进展显示文摘细胞核形态的变化在恶性肿瘤中普遍存在,但对其潜在的分子机制及作用仍知之甚少。核纤层蛋白参与支撑核结构,其表达的改变是肿瘤进展期间核形态改变的分子基础。近年来有关核纤层蛋白与恶性肿瘤关系的研究取得了较大进展,核纤层蛋白对多种恶性肿瘤的诊断、治疗及预后有重要价值。 | 邓海孝 俞泽元 康继贺 秦俊杰 蒋祥彦 焦作义 | 2020 | 中南大学学报(医学版)2020，45，12： | 1 |
| 2 | Aberrant nuclear lamina contributes to the malignancy of human gliomas显示文摘Glioma is the most common type of tumor in the central nervous system, accounting for around 80% of all malignant brain tumors. Previous studies showed a significant association between nuclear morphology and the malignant progress of gliomas. By virtue of integrated proteomics and genomics analyses as well as experimental validations, we identify three nuclear lamin genes(LMNA, LMNB1, and LMNB2) that are significantly upregulated in glioma tissues compared with normal brain tissues. We show that elevated expressions of LMNB1, LMNB2, and LMNA in glioma cells are highly associated with the rapid progression of the disease and the knockdown of LMNB1, LMNB2, and LMNA dramatically suppresses glioma progression in both in vitro and in vivo mouse models. Moreover, the repression of glioma cell growth by lamin knockdown is mediated by the p Rb-mediated G1-S inhibition. On the contrary, overexpression of lamins in normal human astrocytes dramatically induced nuclear morphological aberrations and accelerated cell growth. Together, our multi-omics-based analysis has revealed a previously unrecognized role of lamin genes in gliomagenesis, providing a strong support for the key link between aberrant tumor nuclear shape and the survival of glioma patients. Based on these findings, lamins are proposed to be potential oncogene targets for therapeutic treatments of brain tumors. | Shunqi Pei Xuehui Wang Xuan Wang Hao Huang Huaping Tao Binghua Xie Aifen Yang Mengsheng Qiu Zhou Tan | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
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