|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 2 | Triple pharmacologicalblockade of the renin-angiotensin-aldosterone system in nondia-betic CKD:an open-label crossover randomized controlled trial显示文摘 | Tylicki L Rutkowski P Renke M | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 3 | Randomized, controlled study of the effects of losartan versus enalapril in small doses on proteinuria and tubular injury in primary glomerulonephritis显示文摘 | Tylicki L Renke M Rutkowski P | 2005 | Med Sci Monit2005，11，4： | 1 |
| 4 | Imatinib mesy- late in advanced dermatofibrosarooma protuberans: pooled analysis of two phase Ⅱ clinical trials显示文摘 | Rutkowski P Van Glabbeke M Rankin C J | 2010 | J Clin Oneol2010，28，10： | 1 |
| 5 | AT1 Receptor Antagonist Can- desartan Attenuates Genomic Damage in Peripheral Blood Lymphocytes of Patients on Maintenance Hemodialysis Treatment显示文摘 | Schupp N Rutkowski P Sebekova K | 2011 | Kidney and blood pressure research2011，34，3： | 1 |
| 6 | Cytokine and cytokine receptor serum levels in adult bone sarcoma patients:correlations with local tumor extent and prognosis显示文摘 | Rutkowski P Kaminska J Kowalska M | | 0，，03： | 1 |
| 7 | Renal disease in obesity: the need for greater attention显示文摘 | Rutkowski P Klassen A Sebekova K | 2006 | 16:216-2232006，16，： | 1 |
| 8 | Low-dose dual blockade of the renin-angiotensin system in patients with primary glomerulonephritis 显示文摘 | Tylicki L Renke M Korejwo G Zdrojewski Z Rutkowski B | 2004 | Am J Kidney Dis2004，43，2： | 1 |
| 9 | Low-dose angiotensin Ⅱ receptor antagonists and angiotensin Ⅱ-convertlng enzyme inhibitors alone or in combination for treatment of primary glomerulonephritis显示文摘 | Renke M Tylicki L Rutkowski P | 2004 | Seand J Urol Nephrol2004，38，5： | 1 |
| 10 | Renal di sease in obsity:the need for greater attention显示文摘 | RUTKOWSKI P KLASSEN A SEBEKOVA K | 2006 | J Ren Nutr2006，16，3： | 1 |
| 11 | Treatment of advanced protuberans with imatinib mesylate with or without surgical resection显示文摘 | Rutkowski P Debiec-Rychter M Nowecki Z | 2011 | J Eur Acad Dermatol Vene- real2011，25，3： | 1 |
| 12 | Advances in molecular characterization and targeted therapy in dermatoflbrosarcoma protuberans显示文摘 | Rutkowski P Wozniak A Switaj T | 2011 | Sarcoma2011，2011，95： | 1 |
| 13 | Surgery combined with intraoperative brachytherapy in the treatment of retroperitoneal sarcomas显示文摘 | Dziewirski W Rutkowski P Nowecki ZI | 2006 | Ann Surg Oncol2006，13，2： | 1 |
| 14 | Surgical treatment of patients with initially inoperable and/or metastatic gastrointestinal stromal tumors (GIST) duriy therapy with imatinib mesylate 显示文摘 | RUTKOWSKI P NOWECKI Z NYCKOWSKI P | 2006 | J Surg Oncol2006，93，4： | 1 |
| 15 | Renal disease in obsity:the need for greater attention显示文摘 | RUTKOWSKI P KLASSEN A SEBEKOVA K | 2006 | J Ren Nutr2006，16，3： | 1 |
| 16 | Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance显示文摘 | Rutkowsky J M Wallace B K Wise P M | 2011 | Am J Physiol Cell Physiol2011，301，1： | 1 |
| 17 | Blue shifted F3 CH … FCD3 and Cl3 CH … FCD3 weakly H - bound complexes: Cryospectroscopic and ab initio study 显示文摘 | Rutkowski K S Rodziewicz P Melikova S M | 2005 | Chem Phys2005，313，13： | 1 |
| 18 | Expression of CD34 in gastric cancer and its correlation with histology ,stage, proliferation activity,p53 expression and apoptotic index显示文摘 | Tenderenda M Rutkowski P JesionekKupnicka D | 2001 | Pathol Oncol Res2001，7，2： | 1 |
| 19 | Developments intargeted therapy o f advanced gastrointestinal stroaltumors Recent PatAnticance 显示文摘 | Rutkowski P Symonides M Zdzienicki M | 2008 | Recent Pat Anticancer Drug Discov2008，3，2： | 1 |
| 20 | Cytokine and cytokine receptor serum levels in adult bone sarcoma patients:correlations with local tumor extent and prognosis 显示文摘 | Rutkowski P Kaminska J Kowalska M | 2003 | J Surg Oncol2003，84，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员