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| 1 | Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer显示文摘AIM: To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR146a genes are associated with sporadic colorectal cancer (CRC).METHODS: In order to investigate the effect of these SNPs in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis. RESULTS: The genotype and allele frequencies of SNPs were compared between the cases and the controls. None of the performed analysis showed any statistically significant results. CONCLUSION: Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer. | Renata Hezova Alena Kovarikova Julie Bienertova-Vasku Milana Sachlova Martina Redova Anna Vasku Marek Svoboda Lenka Radova Igor Kiss Rostislav Vyzula Ondrej Slaby | 2012 | World Journal of Gastroenterology2012，18，22： | 6 |
| 2 | 高级别胶质瘤放、化疗耐药性可能与microRNAs相关(英文)显示文摘High-grade gliomas(HGGs) are malignant primary brain tumors of glial cell origin.Despite optimal course of treatment,including maximal surgical resection followed by adjuvant chemo-and/or radiotherapy,the prognosis still remains poor.The main reason is the commonly occurring chemo-and radioresistance of these tumors.In recent years,several signaling pathways,especially PI3K/AKT and ATM/CHK2/p53,have been linked to the resistance of gliomas.Moreover,additional studies have shown that these pathways are significantly regulated by microRNAs(miRNAs),short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis,proliferation,cell cycle,invasivity,and angiogenesis.MiRNAs are not only highly deregulated in gliomas,their expression signatures have also been shown to predict prognosis and therapy response.Therefore,they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients.In this review,we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo-and radiotherapy. | Besse A Sana J Fadrus P Slaby O | 2013 | 中华神经外科疾病研究杂志2013，12，2： | 3 |
| 3 | Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells显示文摘 | Petra Faltejskova Andrej Besse Sabina Sevcikova Lenka Kubiczkova Marek Svoboda Jan Smarda Igor Kiss Rostislav Vyzula Ondrej Slaby | 2012 | International Journal of Colorectal Disease2012，，11： | 2 |
| 4 | RNA-sequencing of paired pre- treatment and relapse samples reveals differentially expressed genes associated with lenalidomide t~sistanee in multiple myeloma显示文摘 | Neri P Gratton K Slaby LR | 2013 | Blood (ASH Annual Meeting Abstracts)2013，122，： | 1 |
| 5 | Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance显示文摘 | Kubiczkova L Kryukov F Slaby O | 2014 | Haematologica2014，99，： | 1 |
| 6 | Altered expression of MIR-21,miR-31,miR143 and miR-145 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，： | 1 |
| 7 | Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer显示文摘 | Ondrej Slaby Milana Sachlova Veronika Brezkova Renata Hezova Alena Kovarikova Svatava Bischofová Sabina Sevcikova Julie Bienertova-Vasku Anna Vasku Marek Svoboda Rostislav Vyzula | 2013 | Nutrition and Cancer2013，，2： | 1 |
| 8 | Mantled alkali-feldspar megacrysts from the marginal part of the Karkonosze granitoid massif (SW Poland)显示文摘 | Slaby E Galbarczyk-Gasiorowska L Baszkiewicz A | 2002 | Acta Geologica Polonica2002，52，4： | 1 |
| 9 | Altered expression of miR- 21 ,miR-31 ,miR-143 and miR-145 is related to clinico- pathologic features of colorectal cancer 显示文摘 | Slaby O Svoboda M Fabian P | 2007 | Oncology2007，72，56： | 1 |
| 10 | Gene expression of somatostatin receptor 4 predicts clinical outcome of patients with metastatic neuroendocrine tumors treated with somatostatin analogs 显示文摘 | Slaby O Sachlova M Bednarikova M | 2010 | Cancer Biother Radiopharm2010，25，2： | 1 |
| 11 | Feldspar crystallization under magma-mixing conditions shown by cathodoluminescence and geochemical modelling-a case study from the Karkonosze pluton (SW Poland)显示文摘 | Slaby E Gotze J | 2004 | Mineralogical Magazine2004，68，4： | 1 |
| 12 | Alkali feldspar megacryst growth:Geochemical modelling显示文摘 | Slaby E Galbarczyk-Gsiorowska L Seltmann R | 2007 | Mineralogy and Petrology2007，89，1： | 1 |
| 13 | Altered Expression of miR-21,miR-31,miR-143 and miR-145 Is Related to Clinico-pathologic Features of Colorectal Cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，06： | 1 |
| 14 | Metastatic Melanoma With Multiple Small Bowel Intussusceptions显示文摘 | John Slaby Uma Suri | 2009 | Clinical Nuclear Medicine2009，，7： | 1 |
| 15 | Altered expression of miR-21, miR-31, miR- 143 andmiR-145 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M | 2007 | Oncology2007，72，1： | 1 |
| 16 | MicroRNA-342,microRNA-191 and microBNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients显示文摘 | Hezova R Slaby O Faltejskova P | 2010 | Cell Immunol2010，260，2： | 1 |
| 17 | Expression of miRNA-106h in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy 显示文摘 | Slaby O Jancovicova J Lakomy R | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 18 | Altered expression of miR-21,miR-31,miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，5： | 1 |
| 19 | Altered expression of mir-21,Mir-31,Mir-143and mir-145is related to clini-copathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，： | 1 |
| 20 | Phase tracking and restoration of circadian rhythms by model-based optimal control显示文摘 | Shaik O S Sager S Slaby O | 2008 | IET Syst Bio12008，2，1： | 1 |
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