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| 1 | An Exploration of Deep-Learning Based Phenotypic Analysis to Detect Spike Regions in Field Conditions for UK Bread Wheat显示文摘Wheat is one of the major crops in the world,with a global demand expected to reach 850 million tons by 2050 that is clearly outpacing current supply.The continual pressure to sustain wheat yield due to the world’s growing population under fluctuating climate conditions requires breeders to increase yield and yield stability across environments.We are working to integrate deep learning into field-based phenotypic analysis to assist breeders in this endeavour.We have utilised wheat images collected by distributed CropQuant phenotyping workstations deployed for multiyear field experiments of UK bread wheat varieties.Based on these image series,we have developed a deep-learning based analysis pipeline to segment spike regions from complicated backgrounds.As a first step towards robust measurement of key yield traits in the field,we present a promising approach that employ Fully Convolutional Network(FCN)to performsemantic segmentation of images to segment wheat spike regions.We also demonstrate the benefits of transfer learning through the use of parameters obtained from other image datasets.We found that the FCN architecture had achieved a Mean classification Accuracy(MA)>82%on validation data and>76%on test data and Mean Intersection over Union value(MIoU)>73%on validation data and and>64%on test datasets.Through this phenomics research,we trust our attempt is likely to form a sound foundation for extracting key yield-related traits such as spikes per unit area and spikelet number per spike,which can be used to assist yield-focused wheat breeding objectives in near future. | Tahani Alkhudaydi Daniel Reynolds Simon Griffiths Ji Zhou Beatriz de la Iglesia | 2019 | Plant Phenomics2019，1，1： | 5 |
| 2 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 3 | Inheritance patterns of secondary symbionts during sexual reproduction of pea aphid biotypes显示文摘食草的昆虫经常怀有影响他们的生态学和进化的细菌的共生者。蚜虫招待应尽的 endosymbiont Buchnera,它为复制被要求,和其频率越过蚜虫人口变化的容许的共生者。这些似母亲播送了第二等的共生者特别地在豌豆蚜虫被学习了, Acyrthosiphon pisum,哪个港口穿上环境地依赖的效果的至少 8 不同细菌的种类(不数的 Buchnera ) 主人健康。特别地,这些共生者种类与豌豆蚜虫人口在特定的植物上喂被联系。尽管他们是继承的似母亲,这些细菌偶尔越过昆虫系被转移。如此的 nonmaternal 转移的一机制在性复制期间是到子孙的父亲的传播。迄今为止,第二等的共生者的传播在仅仅蚜虫系和 3 共生者种类的一把在蚜虫的性复制期间被调查了。更好描绘这个过程,我们通过包含属于 9 专业化主人的遗传因子型,和 117 个十字的 49 克隆的一个交叉实验在豌豆蚜虫的性复制期间调查了 7 共生者种类的继承模式。在子孙的共生者种类在从鸡蛋并且在以后的单性生殖的代孵化的 fundatrix 阶段与诊断质的 PCR 被检测。我们没发现共生者的父亲的传播的证实的案例到子孙,并且我们观察到特别共生者种(Serratia symbiotica ) 的母亲的传播是相当低效的。我们在尊重讨论这些观察到豌豆蚜虫的生态学。 | Jean Peccoud Joêl Bonhomme Frédérique Mahéo Manon de la Huerta Olivier Cosson Jean-Christophe Simon | 2014 | Insect Science2014，21，3： | 4 |
| 4 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 5 | Coronary artery calcium areas by electron beam computed tomography and coronary atherosclerotic plaque area: A histopathologic corrlative study 显示文摘 | Simons DB Fitzpatrick LA Sheedy PF Schwartz RS | 1995 | Circulatiom1995，92，： | 1 |
| 6 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 7 | B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression显示文摘 | Simon 1 Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 8 | Does a diagnosis of the metabolic syndrome provide additional predietion of eardiovaseular dis- ease and total mortality in the elderly? The Dubbo study 显示文摘 | Simons LA Simons J Ffiedlander Y | 2007 | Med JAust2007，186，8： | 1 |
| 9 | Is depression a risk factor for ischemic stroke显示文摘 | Simons LA | 2001 | Stroke2001，32，： | 1 |
| 10 | Phytoestrogens Do Not Influence Lipoprotein Levels or Endothelial Function in Healthy Postmenopausal Women显示文摘 | Simons LA Konigsmark MV Simons J | 2000 | Am J Cardiol2000，85，11： | 1 |
| 11 | B7-H4 is overexpressed in early-stage ovarian cancer and is independent of CAl25 expression显示文摘 | Simon I Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 12 | Fasting plasmaglucose in non-diabetic elderly women predicts increased all-causesmortality and coronary heart disease risk显示文摘 | Simons LA Friedlander Y McCallum J | 2000 | Aust N Z J Med2000，30，1： | 1 |
| 13 | BY1023/ SL&F96022;biochemistry of a novel ( H -- -- K-I- ) -- ATP ade inhibitor显示文摘 | SIMON WA KEELING DJ LAING SM | 1990 | Bioehem Pharmacol1990，39，： | 1 |
| 14 | Comparison of usefulness of systolic,diastolic and mean blood pressure and pulse pressure as predictors of cardiovascular death in patients≥60 years of age显示文摘 | Palaniappan L Simons LA Simons J | 2002 | Am J Cardiol2002，90，12： | 1 |
| 15 | Tunneling显示文摘 | Johnson Simon Rafael La Porta Florencio Lope- De-Silanes and Andrei Shleifer | 2000 | The American Economic Review2000，，90： | 1 |
| 16 | B7-H4 is over-expressed in earlystage ovarian cancer and is independent of CA125 expression显示文摘 | Simon I Katsaros D Rigault de la Longrais l | 2007 | Gynecol (hacol2007，106，2： | 1 |
| 17 | Stability of hydrolyticenzymes in water-organic solvent systems显示文摘 | Simon L M La' szlo' K Ve' rtesi A | 1998 | J Mol Catal B: Enzym1998，4，： | 1 |
| 18 | Tunneling显示文摘 | Johnson Simon Rafael La Porta Florencio Lopez-de-Silanes Andrei Shleifer | 2000 | Journal of Economic Literature2000，90，2： | 1 |
| 19 | Tunneling 显示文摘 | Johnson Simon Rafael La Porta Floreneio Lopez-de-Silanes and Andrei Shleifer | 2000 | American Economic Review2000，90，： | 1 |
| 20 | Tunneling显示文摘 | JOHNSON SIMON LA PORT R LOPEZ-DE-SILANES F SHLEIFER A | 2000 | American Economic Review Papers and Proceedings2000，90，： | 1 |
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