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| 1 | Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study显示文摘BACKGROUND Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder. Dysregulation of the gut–brain axis plays a central role in the pathophysiology of IBS. It is increasingly clear that the microbiome plays a key role in the development and normal functioning of the gut–brain axis.AIM To facilitate the identification of specific areas of focus that may be of relevance to future research. This study represents a bibliometric analysis of the literature pertaining to the microbiome in IBS to understand the development of this field.METHODS The data used in our bibliometric analysis were retrieved from the Scopus database. The terms related to IBS and microbiome were searched in titles or abstracts within the period of 2000–2019. VOSviewer software was used for data visualization.RESULTS A total of 13055 documents related to IBS were retrieved at the global level. There were 1872 scientific publications focused on the microbiome in IBS. There was a strong positive correlation between publication productivity related to IBS in all fields and productivity related to the microbiome in IBS(r = 0.951, P < 0.001). The United States was the most prolific country with 449(24%) publications, followed by the United Kingdom(n = 176, 9.4%), China(n = 154, 8.2%), and Italy(n = 151, 8.1%). The h-index for all retrieved publications related to the microbiome in IBS was 138. The hot topics were stratified into four clusters:(1) The gut–brain axis related to IBS;(2) Clinical trials related to IBS and the microbiome;(3) Drugmediated manipulation of the gut microbiome;and(4) The role of the altered composition of intestinal microbiota in IBS prevention.CONCLUSION This is the first study to evaluate and quantify global research productivity pertaining to the microbiome in IBS. The number of publications regarding the gut microbiota in IBS has continuously grown since 2013. This finding suggests that the future outlook for interventions targeting the gut microbiota in IBS remains promising. | Sa'ed H Zyoud Simon Smale W Stephen Waring Waleed Sweileh Samah W Al-Jabi | 2021 | World Journal of Gastroenterology2021，27，13： | 2 |
| 2 | Death after percutaneous dilatational tracheostomy:a systematic review and analysis of risk factors显示文摘 | Simon M Metsehke M Braune SA | | 0，，05： | 1 |
| 3 | A randomised controlled trial comparing three analgesia regimens following total knee joint replacement:continuous femoral nerve block,intrathecal morphine or both显示文摘 | Olive DJ Barrington MJ Simone SA | 2015 | Anaesth Intensive Care2015，43，4： | 1 |
| 4 | The activation mechanism of rat vanlloid receptor,by capsaicin involves the poredomain and differs from the activation by either acid or heat显示文摘 | Welch JM Simon SA Reinhart PH | 2000 | Proc Natl Acad Sci USA2000，97，13： | 1 |
| 5 | The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1)显示文摘 | Morales-L~tzaro SL Simon SA Rosenbaum T | 2013 | l Physiol2013，591，13： | 1 |
| 6 | The Efficacy and Safety of Oral Anticoagulants in Warfarin-Suitable Patients With Nonva- lvular Atrial Fibrillation: Systematic Review and Meta-Analysis 显示文摘 | Mitchell SA Simon TA Raza S | 2013 | Clin Appl Thromb Hemost2013，19，6： | 1 |
| 7 | Biology of hypoxia-inducible factor-2alpha in development and disease 显示文摘 | Patel SA Simon MC | 2008 | Cell Death Differ2008，15，4： | 1 |
| 8 | The impact pf O2 availability on human cancer显示文摘 | Bertout JA Patel SA Simon MC | | 0，，： | 1 |
| 9 | Mycoplasma pneumoniae-associated nephritis in children显示文摘 | MH Sa MP Layani Simone | | 0，，01： | 1 |
| 10 | Capsaicin-induced currents with distinet desensitization and Ca^2+ dependence in rat trigeminal ganglion cells显示文摘 | Liu L Simon SA | 1996 | J Neurophysiol1996，75，4： | 1 |
| 11 | Clinical Phase I study with an Insulin-like Growth Factor-1 Receptor Inhibitor: Experiences in patients with squamous non-small cell lung carcinoma显示文摘 | Simon Ekman Jan-Erik Fr? din Johan Harmenberg Antonina Bergman ? sa Hedlund Pia Dahg Carina Alvfors Birgitta St? hl Stefan Bergstr? m Michael Bergqvist | 2011 | Acta Oncologica2011，，3： | 1 |
| 12 | TRPVI: on the road to pain relief显示文摘 | Jara-Oseguera A SA Simon T Rosenbaum | 2008 | Curr Mol Pharmacol2008，1，3： | 1 |
| 13 | The impact of 02 availabilityon human cancer显示文摘 | Bertout JA Patel SA Simon MC | 2008 | Nat Rev Cancer2008，8，12： | 1 |
| 14 | A review of clinical and radio- logical features of cleidocranial dysplasia with a report of two cases and a dental treatment protocol 显示文摘 | Paul SA Simon SS Karthik AK | 2015 | J Pharm Bioallied Sci2015，7，2： | 1 |
| 15 | Plant microRNAs display differential 3' truncation and tailing modifications that are ARGONAUTE1 dependent and conserved across species显示文摘 | Zhai J Zhao Y Simon SA | 2013 | The Plant Cell Online2013，25，7： | 1 |
| 16 | Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons 显示文摘 | Liu L Oortgiesen M Li L Simon SA | 2001 | J Neurophysiol2001，85，2： | 1 |
| 17 | Biology of hypoxia-inducible factor 2alpha in development and disease显示文摘 | Patel SA Simon MC | 2008 | Cell Death Differ2008，15，4： | 1 |
| 18 | National complication rates after pancreatectomy: beyond mere mortality显示文摘 | Simons JP Shah SA Ng SC | 2009 | J Gastrointest Surg2009，13，10： | 1 |
| 19 | The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons显示文摘 | Liu L Yang T Simon SA | 2004 | Pain2004，112，12： | 1 |
| 20 | Preliminary report on the biocompatibility of a moldable, resorbable, composite bone graft consisting of calcium phosphate cement andpoly(lactide-co-glycolide) microspheres显示文摘 | Simon CG Khatri CA Wight SA | 2002 | J Orthop Res2002，20，： | 1 |
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