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| 1 | Treatment of meniscal tears: An evidence based approach显示文摘Treatment options for meniscal tears fall into three broad categories;non-operative,meniscectomy or meniscal repair.Selecting the most appropriate treatment for a given patient involves both patient factors(e.g.,age,co-morbidities and compliance)and tear characteristics(e.g.,location of tear/age/reducibility of tear).There is evidence suggesting that degenerative tears in older patients without mechanical symptoms can be effectively treated non-operatively with a structured physical therapy programme as a first line.Even if these patients later require meniscectomy they will still achieve similar functional outcomes than if they had initially been treated surgically.Partial meniscectomy is suitable for symptomatic tears not amenable to repair,and can still preserve meniscal function especially when the peripheral meniscal rim is intact.Meniscal repair shows 80%success at 2 years and is more suitable in younger patients with reducible tears that are peripheral(e.g.,nearer the capsular attachment)and horizontal or longitudinal in nature.However,careful patient selection and repair technique is required with good compliance to post-operative rehabilitation,which often consists of bracing and non-weight bearing for 4-6 wk. | Simon C Mordecai Nawfal Al-Hadithy Howard E Ware Chinmay M Gupte | 2014 | World Journal of Orthopedics2014，5，3： | 18 |
| 2 | Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy显示文摘肝的脑病(他) 普通 neuro 精神病学的畸形,它从肝细胞失败或 portosystemic 与肝疾病和结果复杂化病人的功课正在推延。表明他是广泛地可变的并且从温和无临床症状的骚乱包含一个系列到深昏迷。研究兴趣集中于传播导出勇气的毒素的角色,特别地氨,胀大的大脑的开发和在导致全球 CNS 消沉和混乱功能的服的 neurotransmitter 系统的变化。直到最近,服的功能的直接调查有在人是困难的。然而,当磁性的回声光谱学( 1H 太太)检测的质子在大脑生物化学变化时,新磁性的回声成像( MRI )技术在大脑体积( coregistered MRI )和损害大脑功能( fMRI )提供对变化的评价的一个非侵略的工具,包括服的 osmolytes 的直接测量,例如 myoinositol ,充斥管理对细胞的动态平衡内在的过程的使挫折和夫酸安,包括细胞内部的水的累积。这些细胞内部的 osmolytes 的集中与 hyperammonaemia 改变。有 neuropsychiatric 缺陷并且自从先生系列的严厉的检测太太的代谢物畸形相互关联向正常术后疗法回来,技术可能具有在客观耐心的监视并且在估计各种各样的治疗政体的有效性的使用。 | VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，19： | 8 |
| 3 | Recurrent ectopic pancreatitis of the jejunum and mesentery over a 30-year period显示文摘BACKGROUND:Ectopic pancreas is defined as pancreatic tissue found outside its usual anatomical position,with no ductal or vascular communication with the native pancreas. We describe a case of ectopic pancreas of the small bowel and mesentery causing recurrent episodes of pancreatitis, initially suspected on computed tomography(CT)and magnetic resonance cholangiopancreatography(MRCP),and confirmed on histological review of the resection. METHODS:A 67-year-old woman presented with clinical symptoms and biochemical evidence of pancreatitis.She had similar episodes over the past 30 years with unrevealing investigations,and was concluded to have idiopathic pancreatitis. She underwent CT and MRCP,with findings suggestive of ectopic pancreas,a diagnosis confirmed on histology of the resection. RESULTS:MRCP identified a mass in the proximal small bowel mesentery isointense to the native pancreas,with a small duct draining into a proximal jejunal loop.The resected specimen consisted of normal parenchyma with lobulated acinar tissue with scattered islets of Langerhans,an occasional ductular structure,and admixed areas of adipose tissue.The patient remained asymptomatic with normal biochemistry six months post-operatively. CONCLUSION:In an individual with abdominal pain,elevated serum amylase/lipase,but imaging findings of a normal native pancreas,ectopic pancreatitis should be considered,and can be evaluated by CT and MRCP. | John CT Wong Charlotte Robinson Edward C Jones Alison Harris Charles Zwirewich Robert Wakefield Richard K Simons Eric M Yoshida | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 4 |
| 4 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 5 | Enemy at the gates: dendritic cells and immunity to mucosal pathogens显示文摘树枝状的房间(DC ) 是用作在天生、适应的免疫之间的一座必要的桥的多样、专业化的造血的房间。DC 在淋巴的所有和 nonlymphoid 机关存在并且在到在包括 mucosal 纸巾的上皮的表面的感染的第一个应答者之中。肺,内脏,和阴道 mucosa 显示的 DC 反映各独特的织物的不同显型和功能并且与他们在怒气和淋巴节点的对应物相对照,常常暴露于他们的环境的有害、良性的因素。Mucosal DC 认出并且通过模式识别的约会回答受体,和激活的 DC 移居到排干淋巴节点导致适应有免疫力的回答到病原体。DC 的专业化函数在 mucosa 帮助免疫和病原体控制的正式就职。如此的专门化包括有势力到病毒的 nucleic 酸,到在内脏腔的俘获有机体的 mucosal DC 的能力,到从另外的感染的房间的跨礼品的抗原的 DC 的能力,和开始 IgA 班在 B 房间切换的 mucosal DC 的能力的 plasmacytoid DC 的抗病毒的干扰素反应。DC 粘性在对 mucosal 病原体的有免疫力的反应也是批评的,当 DC 能对微型环境作出回应并且在附近的上皮的房间察觉到导致病原体的应力。最后, DC 通过串音与对方一起交往支持抗原表示和 T 房间免疫。一起,为对病原体的定制的有免疫力的回答的正式就职的这些过程条件 mucosal DC。 | Adam C Soloff | 2010 | Cell Research2010，20，8： | 4 |
| 6 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 7 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 8 | 植物鞣剂/MUF树脂鞣制时皮革的耐光性及鞣剂的抗老化性显示文摘制备了一种蜜胺含量相对较低的新型磺化蜜胺-脲-甲醛(MUF)缩聚树脂,此树脂与不同的天然植物鞣质复合鞣革,成革具有和铬鞣革一样良好的性能。提出了不同的鞣质/MUF树脂复合物鞣制的皮革,在长时间的紫外线辐射下,以革色的变化作为老化时间的函数,建立并阐明了此函数的预测模型和公式。此函数不仅与固态纯鞣质的抗老化能力有关,还与其在皮革内总体的抗老化能力有关。 | B George A Pizzi C Simon M C Triboulot 张业聪 付丽红 | 2007 | 中国皮革2007，36，15： | 2 |
| 9 | Recognition and management of cardiac arrhythmias显示文摘 | Simon C Kenneth M K | 1995 | Curr Probl Cardiol1995，20，2： | 1 |
| 10 | 3-Hydroxybenzo pyrene in the urine of smokers and non-smokers显示文摘 | Lafontaine M Champmartin C Simon P | 2006 | Toxicol Lett2006，162，23： | 1 |
| 11 | Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development显示文摘 | Maltepe E Simon M C | 1998 | J Mol Med1998，76，： | 1 |
| 12 | Effect of age on sperm fertility potential:oocyte donation as a model显示文摘 | Gallardo E Simon C Levy M | 1996 | Fertil Steril1996，66，2： | 1 |
| 13 | Activation and early parthenogenesis of bovine oocytes treated with ethanol and strontium显示文摘 | Simone C M Claudia L V L Joaquim M G | 2004 | Animal Reproduction Science2004，81，： | 1 |
| 14 | Automotive tribology o- verview of current advances and challenges for the future 显示文摘 | Simon C Tung M L Mc Millan | 2004 | Tribology International2004，1，37： | 1 |
| 15 | Genetic determinants of response to clopidogrel and cardiovascular events 显示文摘 | Simon T Verstuyft C Mary-Kranse M | 2009 | N Engl J Med2009，360，4： | 1 |
| 16 | Genetic determinants of response to clopidogrel and cardiovascular events 显示文摘 | Simon T Verstuyft C Mary-Krause M | 2009 | N Engl J Med2009，360，： | 1 |
| 17 | Outcomed and clinicopa thologic variables associated with late recurrence after nephrectomy fkr localiged Renal cell carcinoma显示文摘 | SIMON P K CHRISTOPHER J M BRADLEY C L | 2011 | Urology2011，78，5： | 1 |
| 18 | Hypoxia, HIFs, and cardiovascular development显示文摘 | Simon M C Ramircz-Bergeron D Mack F | 2003 | Cold Spring Harb Symp Quant Biol2003，67，： | 1 |
| 19 | The measurement and determinants of brand equity: a financial ap- proach显示文摘 | Simon C J Sullivan M W | 1993 | Marketing Science1993，，： | 1 |
| 20 | Direct reprogramming of human astrocytes into neural stem cells and neurons 显示文摘 | Corti S Nizzardo M Simone C | 2012 | Exp Cell Res2012，318，13： | 1 |
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