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| 1 | Vascular access today显示文摘The number of patients with chronic kidney disease requiring renal replacement therapy has increased worldwide. The most common replacement therapy is hemodialysis(HD). Vascular access(VA) has a key role for successful treatment. Despite the advances that have taken place in the field of the HD procedure, few things have changed with regards to VA in recent years. Arteriovenous fistula(AVF), polytetrafluoroethylene graft and the cuffed double lumen silicone catheter are the most common used for VA. In the long term, a number of complications may present and more than one VA is needed during the HD life. The most common complications for all of VA types are thrombosis, bleeding and infection, the most common cause of morbidity in these patients. It has been estimated that VA dysfunction is responsible for 20% of all hospitalizations. The annual cost of placing and looking after dialysis VA in the United States exceeds 1 billion dollars per year. A good functional access is also vital in order to deliver adequate HD therapy. It seems that the native AVF that Brescia and Cimino described in 1966 still remains the first choice for VA. The native forearm AVFs have the longest survival and require the fewest interventions. For this reason, the forearm AVF is the first choice, followed by the upper-arm AVF, the arteriovenous graft and the cuffed central venous catheter is the final choice. In conclusion, VA remains the most importantissue for patients on HD and despite the technical improvements, a number of problems and complications have to be resolved. | Konstantinos Pantelias Eirini Grapsa | 2012 | World Journal of Nephrology2012，1，3： | 9 |
| 2 | Myocardial infarction with non-obstructive coronary arteries: A comprehensive review and future research directions显示文摘Acute coronary syndromes constitute a variety of myocardial injury presentations that include a subset of patients presenting with myocardial infarction with non-obstructive coronary arteries(MINOCA).This acute coronary syndrome differs from type 1 myocardial infarction(MI)regarding patient characteristics,presentation,physiopathology,management,treatment,and prognosis.Two-thirds of MINOCA subjects present ST-segment elevation;MINOCA patients are younger,are more often female and tend to have fewer cardiovascular risk factors.Moreover,MINOCA is a working diagnosis,and defining the aetiologic mechanism is relevant because it affects patient care and prognosis.In the absence of relevant coronary artery disease,myocardial ischaemia might be triggered by an acute event in epicardial coronary arteries,coronary microcirculation,or both.Epicardial causes of MINOCA include coronary plaque disruption,coronary dissection,and coronary spasm.Microvascular MINOCA mechanisms involve microvascular coronary spasm,takotsubo syndrome(TTS),myocarditis,and coronary thromboembolism.Coronary angiography with non-significant coronary stenosis and left ventriculography are first-line tests in the differential study of MINOCA patients.The diagnostic arsenal includes invasive and non-invasive techniques.Medical history and echocardiography can help indicate vasospasm or thrombosis,if one finite coronary territory is affected,or specify TTS if apical ballooning is present.Intravascular ultrasound,optical coherence tomography,and provocative testing are encouraged.Cardiac magnetic resonance is a cornerstone in myocarditis diagnosis.MINOCA is not a benign diagnosis,and its polymorphic forms differ in prognosis.MINOCA care varies across centres,and future multi-centre clinical trials with standardized criteria may have a positive impact on defining optimal cardiovascular care for MINOCA patients. | Rafael Vidal-Perez Charigan Abou Jokh Casas Rosa Maria Agra-Bermejo Belén Alvarez-Alvarez Julia Grapsa Ricardo Fontes-Carvalho Pedro Rigueiro Veloso Jose Maria Garcia Acuña Jose Ramon Gonzalez-Juanatey | 2019 | World Journal of Cardiology2019，11，12： | 6 |
| 3 | Targeted therapies for pancreatic adenocarcinoma: Where do we stand, how far can we go?显示文摘Pancreatic adenocarcinoma(usually referred to aspancreatic cancer) is a highly lethal and aggressive malignancy with a disease-related mortality almost equaling its incidence, and one of the most challenging cancers to treat. The notorious resistance of pancreatic cancer not only to conventional cytotoxic therapies but also to almost all targeted agents developed to date, continues to puzzle the oncological community and represents one of the biggest hurdles to reducing the death toll from this ominous disease. This editorial highlights the most important recent advances in preclinical and clinical research, with regards to targeted therapeutics for pancreatic cancer, outlines current challenges and provides an overview of potential future perspectives in this rapidly evolving field. | Dimitra Grapsa Muhammad Wasif Saif Konstantinos Syrigos | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 2 |
| 4 | Correlation of depressive symptoms and olfactory dysfunction in patients on hemodialysis显示文摘 | Grapsa E Samouilidou E Pandelias K | 2010 | Hippokratia2010，14，3： | 1 |
| 5 | Is There Any Association between IgA Nephropathy, Crohn’s Disease and Helicobacter pylori Infection?显示文摘 | Chrysoula Pipili Spyridon Michopoulos Maria Sotiropoulou Tzoulia Mpakirtzi Eirini Grapsa | 2012 | Renal Failure2012，，4： | 1 |
| 6 | Fiddling with the pacemaker: Twiddler's syndrome in a Parkinsonian patient 显示文摘 | Grapsa J Koa - Wing M Fox KF | 2013 | Perfusion2013，28，1： | 1 |
| 7 | Red blood cell distribution width:a strong prognostic marker in cardiovascular disease: is associated with cholesterol content of erythrocyte membrane显示文摘 | Tziakas D Chalikias G Grapsa A | 2012 | Clin Hemorheol Microcirc2012，51，4： | 1 |
| 8 | Retrospective study of pulmonary hypertensive patients is right ventricular myocardial performance index acital prognostic factor显示文摘 | Grapsa I Pavlopoulos H Dawson D | 2007 | Hellenic J Cardiol2007，48，3： | 1 |
| 9 | Is it only diastolic dysfunction? Segmental relaxation patterns and longitudinal systolic deformation in systemic hypertension显示文摘 | Pavlopoulos H Grapsa J Stefanadi E | 2008 | Eur J Echocardiogr2008，9，6： | 1 |
| 10 | Numerical study and optimal blade design of a centrifugal pump by evolutionary algorithms显示文摘 | GRAPSAS V STAMATELOS F ANAGNOSTOPOULOS J | 2008 | Knowledge-Based Intelligent Information and Engineering Systems2008，5178，： | 1 |
| 11 | High coverage of ART associated with decline in risk of HIV acquisition in rural KwaZulu-Natal,South Africa显示文摘 | Tanser F Barnighausen T Grapsa E | 2013 | Science2013，339，6122： | 1 |
| 12 | Right ventricular remod- ellingin puhnonary arterial hypertension with three-dimensional echo- cardiography: comparison with cardiac magnetic resonance imaging 显示文摘 | Grapsa J 0Regan DP Pavlopoulos H | 2010 | Eur J Echocardiogr2010，11，： | 1 |
| 13 | Right ventricular re-modelling in pulmonary arterial hypertension with three-dimen-sional echocardiography:comparison with cardiac magnetic reso-nance imaging显示文摘 | Grapsa J O′Regan DP Pavlopoulos H | | European Journal of Echocardiography0，，： | 1 |
| 14 | Red blood cell distribution width:a strong prognostic marker in cardiovascular disease:is associated with cholesterol content of erythrocyte membrane显示文摘 | Tziakas D Chalikias G Grapsa A | | 0，，4： | 1 |
| 15 | The prog- nostic value of PTEN, p53, and beta - catenin in endometrial carcinoma : a prospective immunocytochemical study 显示文摘 | Athanassiadou P Athanassiades P Grapsa D | 2007 | Int J Gynecol Cancer2007，17，3： | 1 |
| 16 | Periodic therapeutic plasma exchange in patients with moderate to severe chronic myasthenia gravis non-responsive to immunosuppressive agents:an eight year fol ow-up显示文摘 | Triantafyl ou NI Grapsa EI Kararizou E | | 0，，03： | 1 |
| 17 | Ultrafiltration in the treatment of severe congestive heart failure 显示文摘 | Grapsa E Alexopoulos GP Margari Z | 2004 | Int Urol Nephrol2004，36，2： | 1 |
| 18 | Is There Any Association between IgA Nephropathy, Crohn’s Disease and Helicobacter pylori Infection?显示文摘 | Chrysoula Pipili Spyridon Michopoulos Maria Sotiropoulou Tzoulia Mpakirtzi Eirini Grapsa | 2012 | Renal Failure2012，，4： | 1 |
| 19 | Oxidative stress markers and C-reactive protein in end-stage renal failure patients on dialysis显示文摘 | Samouilidou E C Grapsa E J Kakavas I Lagouranis A Agrogiannis B | 2003 | Int Urol Neph rol2003，35，： | 1 |
| 20 | Right ventricular re- modelling in puhnonary arterial hypertension with three-dimensional e- chocardiography:comparison with cardiac magnetic resonance imaging 显示文摘 | Grapsa J O'Regan D P Pavlopoulos H | 2010 | Eur J Eehocardiogr2010，11，1： | 1 |
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