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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | Multi-dimensional, light-controlled switch of fluorescence resonance energy transfer based on orderly assembly of 0D dye@micro-micelles and 2D ultrathin-layered nanosheets显示文摘荧光回声精力转移(烦恼) 系统在视觉察觉,聪明的材料,和生物成像有宽广应用,所有哪个帮助通过多重尺寸并且在多样的方向的光的传播。此处,我们示威了多维(0D 和 2D ) 由采用 layer-by-layer (LBL ) 在一部多层的 ultrathin 电影(UTF ) 以内烦恼集会技术。(tert 丁基 acrylate-co-ethyl acrylate-co-methacrylic 酸)(PTBEM ) anionic 块共聚物 micelle poly 为二度(8-hydroxyquinolate ) 的加入被选择为一个分子的搬运人锌(Znq 2) 和开戒指的 merocyanine (MC )( 是表示了(Znq 2/MC)@PTBEM) 。或者,静电的汇编与 cationic 被执行分层的双氢氧化物(LDH ) nanosheets (是表示了[(Znq 2/MC)@PTBEM/LDH] n ) 。这[(Znq 2/MC)@PTBEM/LDH] n 系统提供多维的繁殖媒介并且保证 FRET 施主和领受人位于他们的 F 以内 ? 在每个方向的 rster 半径。系统表明能经由轮流出现被交换的 FRET 进程紫外 / 可见(UV/vis ) 照耀与悦耳的 blue-green/red 荧光,象 81.7% 一样高导致 FRET 效率。这被期望这个汇编方法,它在 2D 上使用 0D 微粒分层的材料,能为进一步的开发被扩大到另外的系统多维烦恼。 | Zhixiong Li Ruizheng Liang Simin Xu Wendi Liu Dongpeng Yan Min Wei David G. Evans Xue Duan | 2016 | Nano Research2016，9，12： | 4 |
| 3 | Dielectric Properties of Bi_4Ti_3O_(12) Ceramics by Impedance Spectroscopic Method显示文摘Various lead-free ceramics have been investigated in search for new high-temperature dielectrics. In particular, Bi_4Ti_3O_(12) is a type of ferroelectric ceramics, which is supposed to replace leadcontaining ceramics for its outstanding dielectric properties in the near future. Ferroelectric ceramics of Bi_4Ti_3O_(12) made by conventional mixed oxide route have been studied by impedance spectroscopy in a wide range of temperature. X-ray diffraction patterns show that Bi_4Ti_3O_(12) ceramics are a single-phase of ferroelectric Bi-layered perovskite structure whether it is calcined at 800 ℃ or after sintering production. This study focused on the effect of the grain size on the electric properties of BIT ceramics. The BIT ceramics with different grain sizes were prepared at different sintering temperatures. Grain becomes coarser with the sintering temperature increasing by 50 ℃, relative permittivity and dielectric loss also change a lot. When sintered at 1 100 ℃, r values peak can reach 205.40 at a frequency of 100 k Hz, the minimum dielectric losses of four different frequencies make no difference, all close to 0.027. The values of Ea range from 0.52 to 0.68 e V. The dielectric properties of the sample sintered at 1 100 ℃ are relatively better than those of the other samples by analyzing the relationship of the grain, the internal stresses, the homogeneity and the dielectric properties. SEM can better explain the results of the dielectric spectrum at different sintering temperatures. The results show that Bi_4Ti_3O_(12) ceramics are a kind of dielectrics. Thus, Bi_4Ti_3O_(12) can be used in high-temperature capacitors and microwave ceramics. | 陈勇 SU Huyin XUE Simin LI Zhaozhi ZHANG Cancan CHEN Qi XU Lingfang 曹万强 黄兆祥 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 3 |
| 4 | Detection of composition of functional component theabrownins in Pu-erh tea by degradation method显示文摘Habitual tea consumption can reduce the risk of ASCVD morbidity and mortality and all-cause mortality in China,and long-term adherence to this habit can provide greater protection.Pu-erh tea is one of the representatives of post-fermented teas,and the polymers in Pu-erh tea have anti-cancer and anti-hyperlipidemic activities,but their chemical composition is still unknown.In this study,the chemical composition of Pu-erh tea was investigated in detail and eight(1–8)known compounds were isolated.The polymers in Pu-erh tea were also degraded by thiol degradation,and the fragments of quercetin and(–)-epicatechin-3-O-gallate were found in the thiol degradation products of Pu-erh tea polymers by UPLC observation and separation and purification.This is the first time that this fragment was obtained in Pu-erh tea polymer. | Simin Hu Xiaolei Li Chuangchuang Gao Xianyu Meng Mingchao Li Yuqian Li Tianrui Xu Qian Hao | 2022 | Food Science and Human Wellness2022，11，3： | 3 |
| 5 | Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs显示文摘二维(2D ) 因为他们的高特定的表面区域和迷人的物理化学的性质, nanomaterials 在 biomedicine 的地里获得了巨大的注意。此处, 2D monolayered 两倍氢氧化物( MLDH ) nanosheets 被采用本地化 doxorubicin (纪录影片), anticancer 药,与一个装载能力象 3.6 mg 一样高??釯??鶋???????鐿骢鯡????鮪???銬????雞??????飝鱎?鶬微隬悑傘?辬?銬???颬疞???徬?????鶝?铍?鳓钫?鵀?亘??鎪蒠?????????斪?鎬頿??悑?讬鶝???墑???鎛??亘??宫?? | Xuan Mei Simin Xu Tongyang Hu Liuqi Peng Rui Gao Ruizheng Liang Min Wei David G. Evans Xue Duan | 2018 | Nano Research2018，11，1： | 2 |
| 6 | The formation of cu- curhituril (n = 6, 7) complexes with amino com- pounds in aqueous formic acid studied by capillary elec- trophoresis显示文摘 | Fang Wei Liu Simin Xu Li | 2005 | Electrophoresis2005，，26： | 1 |
| 7 | Temporal Evolution of Beam fanning in LiNbO3: Fe in Crystal 显示文摘 | Xinzheng Zhang Jingjun Xu Simin Liu | 2001 | Applied Optics2001，40，5： | 1 |
| 8 | Temperature Effect in (K_(0.5)Na_(0.5))_(0.2)(Sr_(0.75)Ba_(0.25))_(0.9)Nb_(2)0_(6): Cu Crystal Self-Pumped Phase-Conjugator显示文摘A reflectivity of 45%of the self-pumped phase-conjugate wave in (K_(0.5)Na_(0.5))_(0.2)(Sr_(0.75)Ba_(0.25))_(0.9)Nb_(2)0_(6)-Cn crystal at the environmental temperature T~70℃ has been obtained.The temperature effect in this kind of self-pumped phase-conjugator is studied. | XU Jingjun LIU Simin WU Yuanqing ZHANG Guangyin SUN Daliang SONG Yongyuan CHEN Huanchu | 1992 | Chinese Physics Letters1992，9，7： | 1 |
| 9 | A continuous simulation of Holocene effective moisture change represented by variability of virtual lake level in East and Central Asia显示文摘The fluctuation of a single lake level is a comprehensive reflection of water balance within the basin, while the regional consistent fluctuations of lake level can indicate the change of regional effective moisture. Previous researches were mainly focused on reconstructing effective moisture by multiproxy analyses of lake sediments. We carried out a series of experiments, including a transient climate evolution model, a lake energy balance model and a lake water balance model to simulate continuous Holocene effective moisture change represented by variability of virtual lake level in East and Central Asia.The virtual lake level, area, water depth and salinity are not equivalent to actual values, but we estimated relative changes of the regional effective moisture. We also explored the driving mechanisms of effective moisture change in different geographical regions. Our results indicated that gradually falling effective moisture during the Holocene in northern China was due to the combined effects of high lake evaporation caused by longwave and shortwave radiation, and low precipitation caused by reductions of summer solar insolation. A decline in effective moisture through the Holocene in the Tibetan Plateau and southern Central Asia resulted from decreased precipitation because of the weakening of the Asian summer monsoon. Increased precipitation induced by the strengthening of the westerly circulation contributed to the effective moisture rise during the Holocene in northern Central Asia. | Yu LI Yuxin ZHANG Xinzhong ZHANG Wangting YE Lingmei XU Qin HAN Yichan LI Hebin LIU Simin PENG | 2020 | Science China Earth Sciences2020，63，8： | 1 |
| 10 | A systematic methodology for multi-images encryption and decryption based on single chaotic system and FPGA embedded implementation显示文摘 | ZHENG Hanzhong YU Simin and XU Xiangqian | 2014 | Mathematical Problems in Engineering2014，，： | 1 |
| 11 | Single-fundamental-mode 850 nm surface relief VCSEL显示文摘 | Wei Simin Xu Chen Deng Jun | 2012 | Chinese Phys Lett2012，29，08： | 1 |
| 12 | Light-amplification competition betweenfanning noise and the signal beam in doped lithium niobate crystals显示文摘 | Guoquan Zhang Nouel Y Kamber Jingjun Xu Simin Liu Qian Sun Guangyin Zhang | 1999 | J Opt Soc Am B1999，16，6： | 1 |
| 13 | Combining electronic tongue array and chemometrics for discriminating the specific geographical origins of green tea显示文摘 | XU Lu YAN Simin YE Zihong | 2013 | Journal of Analytical Methods in Chemistry2013，，： | 1 |
| 14 | Photorefractive Self-Bending and High-Performance KNSBN:Cu Crystal Self-Pumped Phase-Conjugator显示文摘The mechanism for the high-performance KNSBN:Cu crystal self-pumped phase-conjugator is first put forward in this letter as no-loop photorefractive self-bending succesive four-wave mixing interaction.And the photore fractive backscattering amplification was found to play a very important role in it. | ZHANG Guangyin XU Jingjun WU Yuanqing LIU Simin SUN Daliang SONG Yongyuan CHEN Huanchu | 1992 | Chinese Physics Letters1992，9，1： | 1 |
| 15 | Light-amplification Coition between Fanning Noise and the Signal Beam in Doped Lithium Niobate Crystals 显示文摘 | Guoquan Zhang Nouel Kamber Y Jingjun Xu Simin Liu Qian Sun Guangyin Zhang | 1999 | J Opt Soc Am B1999，16，6： | 1 |
| 16 | Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1显示文摘Macrophages in tumors(tumor-associated macrophages,TAMs),a major population within most tumors,play key homeostatic functions by stimulating angiogenesis,enhancing tumor cell growth,and suppressing antitumor immunity.Resetting TAMs by simple,efficacious and safe approach(s)is highly desirable to enhance antitumor immunity and attenuate tumor cell malignancy.Previously,we used tumor cell-derived microparticles to package chemotherapeutic drugs(drug-MPs),which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments,implicating that drug-MPs might reset TAMs,considering the inhibitory effects of M2 macrophages on neutrophil recruitment and activation.Here,we show that drug-MPs can function as an antitumor immunomodulator by resetting TAMs with M1 phenotype and IFN-βrelease.Mechanistically,drug molecules in tumor MPs activate macrophage lysosomal P450 monooxygenases,resulting in superoxide anion formation,which further amplifies lysosomal ROS production and pH value by activating lysosomal NOX2.Consequently,lysosomal Ca^(2+)signaling is activated,thus polarizing macrophages towards M1.Meanwhile,the drug molecules are delivered from lysosomes into the nucleus where they activate DNA sensor hnRNPA2B1 for IFN-βproduction.This lysosomal-nuclear machinery fully arouses the antitumor activity of macrophages by targeting both lysosomal pH and the nuclear innate immunity.These findings highlight that drug-MPs can act as a new immunotherapeutic approach by revitalizing antitumor activity of macrophages.This mechanistic elucidation can be translated to treat malignant ascites by drug-MPs combined with PD-1 blockade. | Keke Wei Huafeng Zhang Shuaishuai Yang Yuxiao Cui Bingxia Zhang Jincheng Liu Liang Tang Yaoyao Tan Simin Liu Shiqi Chen Wu Yuan Xiao Luo Chen Chen Fei Li Junwei Liu Jie Chen Pingwei Xu Jiadi Lv Ke Tang Yi Zhang Jingwei Ma Bo Huang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 17 | Restoration and Amplification of Images Through Randomly-Moving Suspension Particles Using Photorefractive Two-Wave Mixing显示文摘Weak images,which pass through two kinds of suspension media with sizes of randomly-moving suspension particles about 0.05-0.1 cm and 0.01-0.001 cm respectively,are deteriorated by light scattering of particles,but restored and amplified effectively by two-wave mixing in photorefractive crystals with different time constants. | ZHANG Guangyin XU Jingjun LIU Simin MEN Liqiu LIU Junxnin | 1994 | Chinese Physics Letters1994，11，2： | 0 |
| 18 | Lens-Like Effect in LiNbO_(3) : Fe Photorefractive Crystal显示文摘The lens-like effects,both photorefractive effect and thermo-optical effect,were studied in the LiNbO_(3):Fe sheet.The threshold light intensity above which the photorefractive effect was overwhelmed b-v the thermal effect was determined and the thermo-optical coefficient dn/dT is evaluated by the Z-scanning method.The limiting characteristics of LiNbO_(3):Fe sheet is examined. | XU Jingjun LIU Junmin ZHANG Guangyin LIU Simin | 1993 | Chinese Physics Letters1993，10，5： | 0 |
| 19 | Transient-State and Steady-State Light-Induced Scattering in Photorefractive Crystal LiNbO_(3):Fe显示文摘We found that drift-length of light-excited electrons L0 has influence upon the light-induced scattering in LiNbO_(3):Fe crystal.We proposed that one of the necessary conditions for steady-state light-induced scattering is D>L0(where D is the illumination beam size). | LIU Junmin LIU Simin XU Jingjun ZHANG Guangyin XIONG Guisheng MEN Liqiu GUO Ru | 1994 | Chinese Physics Letters1994，11，5： | 0 |
| 20 | The linear and nonlinear optical effects of white light显示文摘An overview of our research group’s experimental and theoretical developments is provided on the linear and nonlinear optical effects of white light since 2003. Their work includes the experimental researches on the white light one-dimensional photovoltaic dark spatial solitons and the waveguides and directional couplers induced by them, the circular and elliptic white-light dark spatial solitons and the white-light photorefractive phase masks, two-dimensional white-light photonic lattices and the applications of the white-light dark spatial solitons in the digital image transmission field, the interaction between the two-dimensional white-light dark spatial solitons to enhance or to improve the correlated degree of the white light through the interaction between the white-light beam and coherent dark spatial solitons, the interaction between the one- or two-dimensional white-light dark spatial solitons and the two-dimensional white-light photonic lattices, respectively. We also numerically simulate the interaction between two or more partially incoherent bright spatial solitons and the white bright spatial soliton pairs in the saturated logarithmic nonlinear medium. We have observed experimentally for the first time, the modulation instability of the coherent light and white light, respectively, in self-defocusing medium and so on. | QI XinYuan LIU SiMin GUO Ru LU Yi GAO YuanMei LIU ZhaoHong HUANG ChunFu ZHANG XiaoHua ZHU Nan XU JingJun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 0 |
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