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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | Multi-dimensional, light-controlled switch of fluorescence resonance energy transfer based on orderly assembly of 0D dye@micro-micelles and 2D ultrathin-layered nanosheets显示文摘荧光回声精力转移(烦恼) 系统在视觉察觉,聪明的材料,和生物成像有宽广应用,所有哪个帮助通过多重尺寸并且在多样的方向的光的传播。此处,我们示威了多维(0D 和 2D ) 由采用 layer-by-layer (LBL ) 在一部多层的 ultrathin 电影(UTF ) 以内烦恼集会技术。(tert 丁基 acrylate-co-ethyl acrylate-co-methacrylic 酸)(PTBEM ) anionic 块共聚物 micelle poly 为二度(8-hydroxyquinolate ) 的加入被选择为一个分子的搬运人锌(Znq 2) 和开戒指的 merocyanine (MC )( 是表示了(Znq 2/MC)@PTBEM) 。或者,静电的汇编与 cationic 被执行分层的双氢氧化物(LDH ) nanosheets (是表示了[(Znq 2/MC)@PTBEM/LDH] n ) 。这[(Znq 2/MC)@PTBEM/LDH] n 系统提供多维的繁殖媒介并且保证 FRET 施主和领受人位于他们的 F 以内 ? 在每个方向的 rster 半径。系统表明能经由轮流出现被交换的 FRET 进程紫外 / 可见(UV/vis ) 照耀与悦耳的 blue-green/red 荧光,象 81.7% 一样高导致 FRET 效率。这被期望这个汇编方法,它在 2D 上使用 0D 微粒分层的材料,能为进一步的开发被扩大到另外的系统多维烦恼。 | Zhixiong Li Ruizheng Liang Simin Xu Wendi Liu Dongpeng Yan Min Wei David G. Evans Xue Duan | 2016 | Nano Research2016，9，12： | 4 |
| 3 | Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers显示文摘Objective: Both exposure to heavy metals and alcohol intake have been related to the risk of type 2 diabetes (T2D). In this study, we aimed to assess the potential interactions between metal exposure and alcohol intake on the risk of T2D and prediabetes in a cohort of Chinese male workers. Methods: We conducted a cross-sectional analysis of 26,008 Chinese male workers in an occupational cohort study from 2011 to 2013. We assessed metal exposure and alcohol consumption at baseline in these workers who were aged ≥20 years. Based on occupations which were categorized according to measured urine metal levels, multiple logistic regression analyses were used to evaluate the independent and joint effects of metal and alcohol exposure on the risk of T2D and prediabetes. Results: Risks of T2D (Ptrend= 0.0 0 1 ) and prediabetes (Ptrend = 0.001) were significantly elevated with increasing number of standard drinks per week, years of drinking, and lifetime alcohol consumption. An adjusted odds ratio (OR) of 6.1 (95% confidence interval [CI]: 4.8-7.8) was observed for the smelting/refining workers (highest metal exposure levels) who had the highest lifetime alcohol consumption (>873 kg)(Pinteraction = 0.018), whereas no statistically significant joint effect was found for prediabetes (Pinteraction =0.515). Conclusions: Both exposures to metal and heavy alcohol intake were associated with the risk of diabetes in this large cohort of male workers. There was a strong interaction between these two exposures in affecting diabetes risk that needs to be confirmed in future studies. | Ai-Min Yang Xiao-Bin Hu Simin Liu Ning Cheng De-Sheng Zhang Juan-Sheng Li Hai-Yan Li Xiao-Wei Ren Na Li Xi-Pin Sheng Jiao Ding Shan Zheng Min-Zheng Wang Tong-Zhang Zheng Ya-Na Bai | 2019 | Chronic Diseases and Translational Medicine2019，5，2： | 4 |
| 4 | Genetic models of structural traps related to normal faults in the Putaohua Oilfield,Songliao Basin显示文摘The Putaohua Oilfi eld is a fault-prolifi c area and the faults have close relation with structural traps. The genetic models of the structural traps in the Putaohua Oilfi eld can be divided into two types: individual fault model and multi-fault interaction model. This is based on the description of displacement distribution of typical individual normal faults, the geometry of the footwall and hanging wall, and the analysis of the interaction between faults and the corresponding change in geometry when the faults grow. The individual fault model is that the displacement reaches a maximum at or near the center of fault and decreases toward the fault tips, so a half-graben is formed on the hanging wall of the fault and a half-anticline is formed on the footwall because of the isostatic process. The multi-fault interaction model is that during the growth of faults, they overlap and interact with each other, and accommodation zones are formed in the overlapping segments. The accommodation zones are favorable targets for hydrocarbon exploration, and the trap characteristics are dependent on the extent of overlap and occurrence of faults. The multi-fault interaction model can be subdivided into three types: synthetic accommodation zone, convergent accommodation zone and divergent accommodation zone. Hydrocarbon migration and accumulation models of each type have been developed. The hydrocarbon migration and accumulation models of the traps with different genetic models have their own characteristics in the different stages of fault growth. | Sun Simin Wu Xinsong Liu Hongtao Wang Changsheng | 2008 | Petroleum Science2008，5，4： | 3 |
| 5 | Development and characterization of novel microsatellite markers for the Common Pheasant(Phasianus colchicus)using RAD-seq显示文摘Background: The Common Pheasant(Phasianus colchicus) Linnaeus, 1758 is the most widespread pheasant in the world and widely introduced as a game bird. Increasing needs for conservation genetics and management of both wild and captive populations require permanent genetic resources, such as polymorphic microsatellites in order to genotype individuals and populations.Methods: In this study, 7598 novel polymorphic microsatellites for the Common Pheasant were isolated using a RAD-seq approach at an Illumina high-throughput sequencing platform. A panel of ten novel microsatellites and three existing ones from the chicken genome were multiplexed and genotyped on a set of 90 individuals of Common Pheasants(representing nine subspecies and ten individuals each) and 10 individuals of the Green Pheasant(P. versicolor).Results: These 13 microsatellites exhibited moderate to high levels of polymorphism, with the number of alleles per locus ranging from 2 to 8 and expected heterozygosities from 0.049 to 0.905. The first analysis of the genetic structure of subspecies/populations using a Bayesian clustering approach, implemented in STRUCTURE, showed two genetic clusters, corresponding to both the Green and the Common Pheasant, with further evidence of subpopulation structuring within the Common Pheasants.Conclusion: These markers are useful genetic tools for sustainable uses and evolutionary studies in these two Phasianus pheasants and probably other closely related game birds. | Biao Wang Xuan Xie Simin Liu Xuejing Wang Hong Pang Yang Liu | 2017 | Chinese Birds2017，，1： | 3 |
| 6 | Cucurbit[10]uril-based chemistry显示文摘Cucurbit[n]urils(CB[n]s,n = 5-8,10,13-15) have been proven to be an interesting macrocyclic family with their distinctive molecular recognition properties and fascinating applications in fields such as catalysis,supramolecular materials, drug delivery and biological systems. With the biggest cavity in the CB[n]s family, CB[10] shows its unique molecular recognition properties that are rather distinctive from other CB[n]s. In this review, we summarize the progresses in CB[10]-based chemistry since CB[10] was first reported as CB[10] CB[5] complex in 2001. Purification, molecular recognition and supramolecular assembly of CB[10] will be described and an outlook will be given for further exploration of CB[10]-based chemistry. | Xiran Yang Fengbo Liu Zhiyong Zhao Feng Liang Haijun Zhang Simin Liu | 2018 | Chinese Chemical Letters2018，29，11： | 2 |
| 7 | Dissolution-precipitation growth of uniform and clean two dimensional transition metal dichalcogenides显示文摘Two dimensional transition metal dichalcogenides(TMDCs)have attracted much interest and shown promise in many applications.However,it is challenging to obtain uniform TMDCs with clean surfaces,because of the difficulties in controlling the way the reactants are supplied to the reaction in the current chemical vapor deposition growth process.Here,we report a new growth approach called’dissolution-precipitation’(DP)growth,where the metal sources are sealed inside glass substrates to control their feeding to the reaction.Noteworthy,the diffusion of metal source inside glass to its surface provides a uniform metal source on the glass surface,and restricts the TMDC growth to only a surface reaction while eliminating unwanted gas-phase reaction.This feature gives rise to highly uniform monolayer TMDCs with a clean surface on centimeter-scale substrates.The DP growth works well for a large variety of TMDCs and their alloys,providing a solid foundation for the controlled growth of clean TMDCs by the fine control of the metal source. | Zhengyang Cai Yongjue Lai Shilong Zhao Rongjie Zhang Junyang Tan Simin Feng Jingyun Zou Lei Tang Junhao Lin Bilu Liu Hui-Ming Cheng | 2021 | National Science Review2021，8，3： | 2 |
| 8 | N,P,and K characteristics of different age groups of temperate coniferous tree species in northwestern China显示文摘This study chose dominant tree species including Picea crassifolia,Pinus armandii and Pinus tabuliformis which are distributed in Qilian Mountains,Xiaolongshan Mountains,and Bailongjiang River.According to the different tree species,ages and components,we sampled leaves,branches,stems,and roots,and measured the contents of Nitrogen,Phosphorus,Potassium,along with soil fertility.The changes of N,P,and K contents in the different tree species were studied,and the relationship between nutrient content and environmental factors was analyzed.The results indicated that the content of P in all three species was the lowest(0.039–0.28 g kg^(-1)),while N content was the highest(0.095–1.72 g kg^(-1)).As the terminal organ of nutrient transport,the nutrient content of leaves was the highest.P.armandii(0.45 g kg^(-1)) had a higher nutrient concentration than P.tabulaeformis(0.19 g kg^(-1)) and P.crassifolia(0.29 g kg^(-1)).The nutrient content of each species was highest in a young forest,but lowest in a mature forest.The nutrient content of all three tree species was significantly affected by soil nutrient content,and negatively correlated with available soil nutrients. | Simin Liu Hao Wang | 2018 | Journal of Forestry Research2018，29，2： | 2 |
| 9 | Experimental demonstration of λ/8 DFB semiconductor laser array for 1.3 μm CWDM system显示文摘In this article,we report the first experimental demonstration of an eight-wavelength λ/8 phased-shifted laser array based on the REC technique in the 1.3 μm wavelength domain.Measurement results exhibit good linearity of lasing wavelength with+/-0.35 nm wavelength residual.The SLM property was ensured with SMSRs all larger than 38 dB.Moreover,the directmodulation performance was also tested.The experimental results show that the modulation bandwidth can reach up to 13GHz even at the small injection current of 40 mA and the measured spurious-free dynamic range(SFDR)is up to 87 dB/Hz2/3,which shows good linearity.These measurements show that REC-based λ/8 phased-shifted laser array has good modulation performance and it may find potential application in actual fiber-optic systems. | LU LinLin HUANG Long SHI YueChun GUO RenJia LIU Rui LI LianYan LI SiMin CHEN XiangFei | 2014 | Science China(Technological Sciences)2014，57，9： | 2 |
| 10 | Probing guest compounds enabling the facile isolation of cucurbit[10]uril显示文摘A large set of commercially available amino compounds were assessed toward binding with cucurbit[10]uril(CB[10]),with the purpose of facilitating the isolation of pure CB[10].We found that the addition of a specific guest into a relevant mixture of CB[n]allowed the displacement of CB[5]from CB[10]?CB[5].Subsequent washing of the resulting(G=guest)with dimethyl sulfoxide(DMSO),enabled to get pure CB[10]in a facile and highly efficient way. | Xiran Yang Zhiyong Zhao Xiongzhi Zhang Simin Liu | 2018 | Science China Chemistry2018，61，7： | 2 |
| 11 | The formation of cu- curhituril (n = 6, 7) complexes with amino com- pounds in aqueous formic acid studied by capillary elec- trophoresis显示文摘 | Fang Wei Liu Simin Xu Li | 2005 | Electrophoresis2005，，26： | 1 |
| 12 | Are Variants in the CAPN10 Gene Related to Risk of Type 2 Diabetes? A Quantitative Assessment of Population and Family-Based Association Studies显示文摘 | Yiqing Song Tianhua Niu JoAnn E. Manson David J. Kwiatkowski Simin Liu | 2004 | The American Journal of Human Genetics2004，，2： | 1 |
| 13 | Dietary Intake of Fruits and Vegetablesand Risk of Cardiovascular Disease显示文摘 | Lydia A Bazzano Mary K Serdula Simin Liu | 2003 | Current atheroscl erosis reports2003，5，6： | 1 |
| 14 | Temporal Evolution of Beam fanning in LiNbO3: Fe in Crystal 显示文摘 | Xinzheng Zhang Jingjun Xu Simin Liu | 2001 | Applied Optics2001，40，5： | 1 |
| 15 | Temperature Effect in (K_(0.5)Na_(0.5))_(0.2)(Sr_(0.75)Ba_(0.25))_(0.9)Nb_(2)0_(6): Cu Crystal Self-Pumped Phase-Conjugator显示文摘A reflectivity of 45%of the self-pumped phase-conjugate wave in (K_(0.5)Na_(0.5))_(0.2)(Sr_(0.75)Ba_(0.25))_(0.9)Nb_(2)0_(6)-Cn crystal at the environmental temperature T~70℃ has been obtained.The temperature effect in this kind of self-pumped phase-conjugator is studied. | XU Jingjun LIU Simin WU Yuanqing ZHANG Guangyin SUN Daliang SONG Yongyuan CHEN Huanchu | 1992 | Chinese Physics Letters1992，9，7： | 1 |
| 16 | Construction of Photoresponsive 3D Structures Based on Triphenylethylene Photochromic Building Blocks显示文摘Photoresponsive materials have been widely used in sensing,bioimaging,molecular switches,information storage,and encryption nowadays.Although a large amount of photoresponsive materials have been reported,the construction of these smart materials into precisely prescribed complex 3D geometries is rarely studied.Here we designed a novel photoresponsive material methyl methacrylate containing triphenylethylene(TrPEF_(2)-MA)that can be directly used for digital light processing(DLP)3D printing.Based on TrPEF_(2)-MA,a series of photoresponsive 3D structures with reversible color switching under ultraviolet/visible light irradiations were fabricated.These complex photoresponsive 3D structures show high resolutions(50μm),excellent repeatability(25 cycles without fatigue),and tunable saturate color degrees.Multicomponent DLP 3D printing processes were also carried out to demonstrate their great properties in information hiding and information-carrying properties.This design strategy for constructing photoresponsive 3D structures is attractive in the area of adaptive camouflage,information hiding,information storage,and flexible electronics. | Xiayu Zhang Fukang Liu Beibei Du Rongjuan Huang Simin Zhang Yunfei He Hailan Wang Jingjing Cui Biao Zhang Tao Yu Wei Huang | 2022 | Research2022，，4： | 1 |
| 17 | Dietary intake of fruits and vegetables and risk of cardiovascular disease显示文摘 | Lydia A. Bazzano MD PhD Mary K. Serdula MD MPH Simin Liu MD ScD | 2003 | Current Atherosclerosis Reports2003，，6： | 1 |
| 18 | Dietary intake of fruit and vegetables and risk of cardiovascular disease显示文摘 | BAZZANO L A SERDULA M K LIU Simin | 2003 | Crurent Atherosclerosis Reports2003，5，： | 1 |
| 19 | A continuous simulation of Holocene effective moisture change represented by variability of virtual lake level in East and Central Asia显示文摘The fluctuation of a single lake level is a comprehensive reflection of water balance within the basin, while the regional consistent fluctuations of lake level can indicate the change of regional effective moisture. Previous researches were mainly focused on reconstructing effective moisture by multiproxy analyses of lake sediments. We carried out a series of experiments, including a transient climate evolution model, a lake energy balance model and a lake water balance model to simulate continuous Holocene effective moisture change represented by variability of virtual lake level in East and Central Asia.The virtual lake level, area, water depth and salinity are not equivalent to actual values, but we estimated relative changes of the regional effective moisture. We also explored the driving mechanisms of effective moisture change in different geographical regions. Our results indicated that gradually falling effective moisture during the Holocene in northern China was due to the combined effects of high lake evaporation caused by longwave and shortwave radiation, and low precipitation caused by reductions of summer solar insolation. A decline in effective moisture through the Holocene in the Tibetan Plateau and southern Central Asia resulted from decreased precipitation because of the weakening of the Asian summer monsoon. Increased precipitation induced by the strengthening of the westerly circulation contributed to the effective moisture rise during the Holocene in northern Central Asia. | Yu LI Yuxin ZHANG Xinzhong ZHANG Wangting YE Lingmei XU Qin HAN Yichan LI Hebin LIU Simin PENG | 2020 | Science China Earth Sciences2020，63，8： | 1 |
| 20 | Study of the self-defocusing in LN:Fe, Mg crystals 显示文摘 | KAMBER N Y ZHANG Guangyin LIU Simin | 2000 | Opt Commun2000，184，56： | 1 |
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