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| 1 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 2 | How Do Delirium and Dementia Increase Length of Stay of Elderly General Medical Inpatients?显示文摘 | Stephen M. Saravay Michael Kaplowitz John Kurek David Zeman Simcha Pollack Sonia Novik Scott Knowlton Michael Brendel Lillian Hoffman | 2011 | Psychosomatics2011，，3： | 3 |
| 3 | Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘Acute pancreatitis is of one the most common gastroenterology-related indications for hospital admissions worldwide.With the widespread reliance on endoscopic retrograde cholangiopancreatography(ERCP)for the management of pancreaticobiliary conditions,post-ERCP pancreatitis(PEP)has come to represent an important etiology of acute pancreatitis.Despite many studies aiming to better understand the pathogenesis and prevention of this iatrogenic disorder,findings have been heterogeneous,and considerable variation in clinical practice exists.Herein,we review the literature regarding PEP with the goal to raise awareness of this entity,discuss recent data,and present evidence-based best practices.We believe this manuscript will be useful for gastrointestinal endoscopists as well as other specialists involved in the management of patients with PEP. | Simcha Weissman Mohamed Ahmed Matthew R Baniqued Dean Ehrlich James H Tabibian | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，6： | 2 |
| 4 | Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights显示文摘The gut microbiome plays an important role in the variation of pharmacologic response.This aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing therapy.The impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of research.Pancreatic adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very limited.Newer studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of PAC.This review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC. | Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman | 2023 | World Journal of Gastroenterology2023，29，25： | 2 |
| 5 | The ab- sence of detectable methylated bases in Drosophi- la melanogaster显示文摘 | SIMCHA U L YOSEF G JOHN S | 1982 | Febs Letters1982，146，1： | 1 |
| 6 | The cyclin D1 gene is a target of the beta- catenin/LEF-1 pathway显示文摘 | Shtutman M Zhurinsky J Simcha I | 1999 | Proc Natl Acad Scl U S A1999，96，10： | 1 |
| 7 | cardic anonalies:ontogeny during pregnancy显示文摘 | Simcha Yagel axicl weissmann | 1996 | J Soc Gynecol Invest1996，3，2： | 1 |
| 8 | The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway 显示文摘 | Shtutman M Zhurinsky J Simcha I | 1999 | Proc Natl Acad Sci U S A1999，96，10： | 1 |
| 9 | Developmentally regulated organ-,tissue-,and cell-specific expression of calmodulin genes in common wheat显示文摘 | Tianhao Yang Simcha Lev-Yadun Moshe Feldman and Hillel Fromm | 1998 | Plant Molecular Biology1998，37，： | 1 |
| 10 | Familial Ebstein's anomaly显示文摘 | Rosenmann A Arad I Simcha A Schaap T | 1976 | J Med Genet1976，13，： | 1 |
| 11 | Tackling the widespread and critical impact of batch effects in high- throughput data显示文摘 | Leek JT Scharpf RB Bravo HC Simcha D Langmead B Johnson WE Geman D Baggerly K Irizarry RA | 2010 | Nat Rev Genet2010，，10： | 1 |
| 12 | The cyclin D1 geneisa target of theβ-catenin/LEF-1 pathway 显示文摘 | Shtutman M Zhurinsky J Simcha I | 1999 | PNAS1999，96，10： | 1 |
| 13 | Three-dimensional transperineal ul-trasonography of the pelvic floor : improving visualization fornew clinical applications and better functional assessment 显示文摘 | Valsky DV Simcha Y | 2007 | Ultrasound Med2007，26，10： | 1 |
| 14 | Laboratory abnormalities in patients with bacterial pneumonia 显示文摘 | Ramkumar TS Joseph M Simcha P | 2003 | Chest2003，111，： | 1 |
| 15 | Pines as model gymnosperms to study evolution, wood formation, and perennial growth显示文摘 | Simcha L Ronald Y | 2000 | Journal of Plant Growth Regulation2000，19，3： | 1 |
| 16 | AHP-based weighting of factors affecting safety on construction sites with tower cranes 显示文摘 | Shapira A Simcha M | 2009 | Journal of Construction Engineering and Management2009，135，4： | 1 |
| 17 | The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway显示文摘 | Shtutman M Zhurinsky J Simcha I | 1999 | Proc Natl Acad Sci U S A1999，96，： | 1 |
| 18 | Laboratory abnormalities in patients with bacterial pneumonia显示文摘 | Ramkumar TS Joseph M Simcha P | 1997 | Chest1997，11，6： | 1 |
| 19 | The cyclin D1 gene is a target of the β-catenin/ LEF-1 pathway 显示文摘 | SHTUTMAN M ZHURINSKY J SIMCHA I | 1999 | Proc NatlAcad SciUSA1999，96，10： | 1 |
| 20 | The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway显示文摘 | Shtutman M J Zhurinsky I Simcha | 1999 | Proc Natl Acad Sci U S A1999，96，10： | 1 |
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