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| 1 | Tackling the widespread and critical impact of batch effects in high- throughput data显示文摘 | Leek JT Scharpf RB Bravo HC Simcha D Langmead B Johnson WE Geman D Baggerly K Irizarry RA | 2010 | Nat Rev Genet2010，，10： | 1 |
| 2 | Differential nuclear translocation and transactivation potential of beta - catenin and plakoglobin显示文摘 | Simcha I Shtutman M Salomon D | 1998 | J Cell Biol1998，141，6： | 1 |
| 3 | Thermal dilution measure- ment of pulmonary and systemic blood tlow in secundum atrial septal defect,and transposition of great arteries with intact interventricular septmn显示文摘 | Silove E D Tyrian M J Simcha A J et d | | Brit Heart0，34，11： | 1 |
| 4 | The saltstress signal transduetion pathway that activates the gpx1 promoter is mediated by intracellular H2O2, different from the pathway induced by extracellular H2O2 显示文摘 | Orna A K Yardena G D Simcha L Y | 2004 | Plant Physiology2004，135，： | 1 |
| 5 | Proportion of thyroid cancer and other cancers in the democratic republic of Congo显示文摘BACKGROUND Cancer diagnosis is increasing around the world and in the Democratic Republic of the Congo(DRC).The proportion of thyroid cancer has increased over the past three decades.There are very few studies on cancer epidemiology,and in particular on thyroid cancer in the DRC.AIM To establish the most recent proportion of thyroid cancer in the DRC compared to other cancers.METHODS This is a retrospective and descriptive study of 6106 consecutive cancer cases listed in the pathological registers of 4 Laboratories in the city of Kinshasa.This study included all cancer cases recorded in the registers between 2005 and 2019.RESULTS From a sample of 6106 patients,including all cancer types,68.3%cases were female and 31.7%were male.Breast and cervical cancer were the most common types of cancer in women and,prostate and skin cancer were the most common types in men.Thyroid cancer was sixth in proportion in women and eleventh in men compared to all cancers.Papillary carcinoma was the most common of thyroid cancers.Rare cancers such as anaplastic and medullary thyroid carcinomas had a proportion of 7%and 2%,respectively.CONCLUSION Newer diagnostic tools led to a surge in cancer diagnoses in the DRC.Thyroid cancer has more than doubled its proportion over the last several decades in the country. | John Bukasa-Kakamba Ayrton I Bangolo Pascal Bayauli Branly Mbunga Francis Iyese Aliocha Nkodila Ali Atoot Gaurav Anand Stacy H Lee Maimona Chaudhary Pamela Q Fernandes Hari PSS Mannam Adithya Polavarapu Merajunissa Merajunnissa Abdullah Azhar Mohan N Alichetty Gauravdeep Singh Georgemar V Arana Jr Imranjot Sekhon Manbir Singh JoséD Rodriguez-Castro Adam Atoot Simcha Weissman Jean Rene M’buyamba | 2023 | World Journal of Experimental Medicine2023，13，3： | 0 |
| 6 | Relationships of hospitalization outcomes and timing to endoscopy in non-variceal upper gastrointestinal bleeding:A nationwide analysis显示文摘BACKGROUND The optimal timing of esophagogastroduodenoscopy(EGD)and the impact of clinico-demographic factors on hospitalization outcomes in non-variceal upper gastrointestinal bleeding(NVUGIB)remains an area of active research.AIM To identify independent predictors of outcomes in patients with NVUGIB,with a particular focus on EGD timing,anticoagulation(AC)status,and demographic features.METHODS A retrospective analysis of adult patients with NVUGIB from 2009 to 2014 was performed using validated ICD-9 codes from the National Inpatient Sample database.Patients were stratified by EGD timing relative to hospital admission(≤24 h,24-48 h,48-72 h,and>72 h)and then by AC status(yes/no).The primary outcome was all-cause inpatient mortality.Secondary outcomes included healthcare usage.RESULTS Of the 1082516 patients admitted for NVUGIB,553186(51.1%)underwent EGD.The mean time to EGD was 52.8 h.Early(<24 h from admission)EGD was associated with significantly decreased mortality,less frequent intensive care unit admission,shorter length of hospital stays,lower hospital costs,and an increased likelihood of discharge to home(all with P<0.001).AC status was not associated with mortality among patients who underwent early EGD(aOR 0.88,P=0.193).Male sex(OR 1.30)and Hispanic(OR 1.10)or Asian(aOR 1.38)race were also independent predictors of adverse hospitalization outcomes in NVUGIB.CONCLUSION Based on this large,nationwide study,early EGD in NVUGIB is associated with lower mortality and decreased healthcare usage,irrespective of AC status.These findings may help guide clinical management and would benefit from prospective validation. | Simcha Weissman Muhammad Aziz Ayrton I Bangolo Dean Ehrlich Arnold Forlemu Anthony Willie Manesh K Gangwani Danish Waqar Hannah Terefe Amritpal Singh Diego MC Gonzalez Jayadev Sajja Fatma L Emiroglu Nicholas Dinko Ahmed Mohamed Mark A Fallorina David Kosoy Ankita Shenoy Anvit Nanavati Joseph D Feuerstein James H Tabibian | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，4： | 0 |
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