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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 3 | Chelate-assisted Phytoextraction of Lead from Contaminated Soils显示文摘 | Cooper E M Sims J T Cumningham S D | 1999 | Environ Qual1999，28，： | 1 |
| 4 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 5 | Soil Inactivation of the Insecticidal Protein within Transgenic Cotton Tissue:Laboratory Microcosms and Field Studies 显示文摘 | SIMS S R REAM J E | 1997 | Agron Food Chem1997，45，： | 1 |
| 6 | IFITM3 inhibits influenza A virus infection by preventing cytosolic entry显示文摘 | Feeley E M Sims J S John S P | 2011 | PLo S Pathogens2011，7，10： | 1 |
| 7 | Phosphorus adsorption and desorption in a sandy soil amended with high rates of coal fly ash 显示文摘 | Sims J T | 1995 | Communications in Soil Science and Plant Analysis1995，26，： | 1 |
| 8 | A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk显示文摘 | Katz E Dubois-Marshall S Sims AH | 2010 | British Journal of Cancer2010，1034，： | 1 |
| 9 | Uncertainty and Economic Activity:Evidence From Business Survey Data显示文摘 | BachmannR Elstner S Sims E | 2013 | Macroeconomics2013，5，2： | 1 |
| 10 | Leafroll Disease is Spreading Rapidly in a Napa Valley Vineyard显示文摘 | GOLINO D A WEBER E Sim S | 2008 | California Agriculture2008，62，4： | 1 |
| 11 | Chelate-assisted phytoextraction of lead from contaminated soils显示文摘 | COOPER E M SIMS J T CUNNINGHAM S D | 1999 | Journal of Environmental Quality1999，28，： | 1 |
| 12 | Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures显示文摘 | Sim W J Lee J W Lee E S | 2011 | Chemosphere2011，82，2： | 1 |
| 13 | Chelate-assisted phytoextraction of lead from contaminated soils显示文摘 | Cooper E M Sims J T Cunningham S D | 1999 | Journal of Environment Quality1999，28，6： | 1 |
| 14 | Phosphorus absorption and desorption in a sand soil amended with high rates of coal fly ash显示文摘 | Reilly S E Sims J P | 1995 | Communications in Soil Science and Plant Analysis1995，26，： | 1 |
| 15 | Chelate-assisted phytoextraction of lead from contaminated soils显示文摘 | Cooper E M Sims J T Cunningham S D | 1999 | J Environ Qual1999，28，： | 1 |
| 16 | Lysozyme separation from egg white by cation exchange column chromatography显示文摘 | LI-CHAN E NAKAI S SIM J | 1986 | Food Sci1986，51，： | 1 |
| 17 | A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk 显示文摘 | Katz E Dubois-Marshall S Sims AH | 2010 | Br J Cancer2010，103，3： | 1 |
| 18 | A heuristic to solve a sea cargo revenue management problem 显示文摘 | LEE L H CHEW E P SIM M S | 2007 | OR Spectrum2007，29，1： | 1 |
| 19 | Synthesis of highly unsymmer trical phthaloeyanines显示文摘 | Ali H Sim S K Lier J E | 1999 | Journal of Chemical Research1999，496，497： | 1 |
| 20 | Rapid evolution of flowering time by an annual plant in response to a climate fluctuation 显示文摘 | Franks S J Sim S Weis A E | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，4： | 1 |
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