|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Molecular cloning and biological characterization of a novel murine lymphoid growth factor显示文摘 | Sims J E Williams D E Morrissey P J | 2000 | J Exp Med2000，192，： | 1 |
| 3 | Genome-wide association study of ankylosing spondylifts identifies nonMHC susceptibility loci显示文摘 | Reveille J D Sims A M Danoy P | | 0，，2： | 1 |
| 4 | Consensus proposals for a unified system of nom enclature of hepatitis C virus genotypes显示文摘 | Sim m onds P Bukh J Com betC | 2005 | H epatology2005，42，4： | 1 |
| 5 | RILEM AAR-5 : Rapid preliminary screeing test for carbonate aggregates 显示文摘 | Sommer H Nixon P J Sims I | 2005 | Materials and Structures2005，38，282： | 1 |
| 6 | Changes in cell wall composition during ripening of grape berries显示文摘 | NUNAN K J SIMS IM BACIC A ROBINSON S P F1NCHER G B | 1998 | Plant Physiology1998，118，3： | 1 |
| 7 | Field performance of transgenic cotton containing the Bt gene显示文摘 | Stone T B Sims S R Marron P G J | 1989 | Proc Invertebr Pathol1989，53，： | 1 |
| 8 | Supercritical carbon dioxide extraction efficiency for carotenes from carrots by RSM显示文摘 | Balaban M O Sims C A | 1996 | Journal of Food Science1996，61，75： | 1 |
| 9 | The structure and function of western North American grasslands III Net primary production, Turnover and efficiencies of energy capture and water use显示文摘 | Sims P L Singh J S | 1978 | Journal of Ecology1978，66，： | 1 |
| 10 | IFITM3 inhibits influenza A virus infection by preventing cytosolic entry显示文摘 | Feeley E M Sims J S John S P | 2011 | PLo S Pathogens2011，7，10： | 1 |
| 11 | An enzyme from the rat liver catalyzing conugation with glutathione显示文摘 | Booth J Boyland E Sims P | 1961 | Biochem J1961，，79： | 1 |
| 12 | An enzyme from rat liver catalyzing conjugations with glutathione显示文摘 | Booth J Boyland E Sims P | 1961 | Biochem J1961，79，： | 1 |
| 13 | Carrying capacity in the tourism industry:A case study of Hengistbury Head显示文摘 | Simón F J G Nurangajavana Y Marqués D P | 2004 | Tourism Management2004，25，： | 1 |
| 14 | Phosphorus absorption and desorption in a sand soil amended with high rates of coal fly ash显示文摘 | Reilly S E Sims J P | 1995 | Communications in Soil Science and Plant Analysis1995，26，： | 1 |
| 15 | Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia:a multi-variate analysis by Cox regression in141patients显示文摘 | CHIM C S SIM J P CHAN C C | 2010 | Hematology2010，15，： | 1 |
| 16 | Body mass is a poor predictor of peak plantar pressure in diabetic men显示文摘 | Cavanagh P R Sims D S Sanders L J | 1991 | Diabetes Care1991，14，8： | 1 |
| 17 | Use of Internet-based resources to support an introductory animal and poultry science course显示文摘 | Barnes D M Sims J P Jamison W | 2000 | Journal of Animal Science2000，77，5： | 1 |
| 18 | Application of CFD in the study of supercritical fluid extraction with structured packing: wet pressure drop calculations显示文摘 | FERNANDES J LISBOA P F SIM(7)ES P C | 2009 | The Journal of SupercriticalFluids2009，50，1： | 1 |
| 19 | Fluorogenic DNA sequencing in PDMS microreactors显示文摘 | Sims P A Greenleaf W J Duan H F | 2011 | Nat Methods2011，8，7： | 1 |
| 20 | Quantitative estimates of water tables and soil moisture in Holocene pestlands from testate amoebae显示文摘 | Woodland W A Charman D J Sims P C | 1998 | The Holocene1998，8，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员