|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 2 | Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method显示文摘The objective of this work is to construct a nanosuspension drug delivery system of probucol,a BCS II drug,in order to improve its dissolution and oral bioavailability.The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticle/nanocrystal aqueous suspension that was further solidified by freeze-drying process.Cellulose derivatives of different substitution groups and molecular weights,including HPMC,HPC,and MC,were evaluated as the primary stabilizer of probucol nanosuspension.Ternary stabilizers system composed of a primary stabilizer(cellulose derivative,i.e.HPC),a nonionic surfactant(Pluronic R F68),and an anionic surfactant(SDS)was employed to obtain probucol nanosuspension of finer particle size and enhanced dissolution in aqueous media.The probucol nanosuspension with good physical stability showed no obvious change of particle size even after storing over 7 d at 4°C or 25°C.The solidified probucol nanosuspension with trehalose as the cryoprotectant showed the highest dissolution rate(>60%at 2 h)compared to other cryoprotectant.The in vivo pharmacokinetic evaluation indicated about 15-folds higher AUC value of the probucol nanosuspension compared to that of coarse probucol suspension after oral administration to rats.The probucol nanosuspension prepared by wet-milling and ternary stabilizers system may find wide applications for improving the dissolution and oral absorption of water-insoluble drugs. | Fang Li Linsen Li Shaoning Wang Yan Yang Jia Li Dongchun Liu Sijie Zhang Siling Wang Hui Xu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 5 |
| 3 | Succinic acid production from or- ange peel and wheat straw by batch fermentations of Fibrobacter suc- cinogenes S85显示文摘 | LI Q SILES JA THOMPSON LP | 2010 | Appl Microbiol Bioteehnol2010，88，3： | 1 |
| 4 | Fabrication of mesoporous hydroxycarbonate apatite for oral delivery of poorly water-soluble drug carvedilol显示文摘 | Qinfu Zhao Tianyi Wang Jing Wang Li Zheng Tongying Jiang Gang Cheng Siling Wang | 2011 | Journal of Non-Crystalline Solids2011，，2： | 1 |
| 5 | A female in vivo haploid-induction system via mutagenesis of egg cell-specific peptidases显示文摘Crop breeding schemes can be significantly accelerated by using(doubled)haploid plants.In vivo haploid induction has been applied in plant breeding for decades but is still not available for all crops and genotypes,and haploidization rates are generally very low.Therefore,methodological improvements to and new concepts for haploidization are required.Here,we report a novel system for the induction of haploid plants by mutating genes encoding egg cell-specific aspartic endopeptidases(ECSs).We show that after successful sperm–egg cell fusion,ECSs play a critical role to ensure male and female nucleus fusion after fertilization.The ecs1 ecs2 double mutant can induce haploids by both selfing and hybridization in Arabidopsis and ECS mutation is also capable of producing haploids in rice.In summary,our study develops a novel approach for maternal haploidization and provides new insights into the molecular basis of fertilization. | Xuecheng Zhang Ce Shi Siling Li Bo Zhang Pan Luo Xiongbo Peng Peng Zhao Thomas Dresselhaus Meng-Xiang Sun | 2023 | Molecular Plant2023，16，2： | 1 |
| 6 | Succinic acid production from orange peel and wheat straw by batch fermentations Fibrobacter succinogenes S85显示文摘 | LI Q SILES A THOMPSON I P | 2010 | Appl Microbiol Biotechnol2010，88，3： | 1 |
| 7 | Saliency-based color image segmentation in foreign fiber detection显示文摘 | Yang Wenzhu Li Daoliang Wang Sile | 2013 | Mathematical and Computer Modelling2013，58，34： | 1 |
| 8 | Succinic Acid Production from Orange Peel and Wheat Straw by Batch Fermentations of Fibrobacter Succinogenes S85 显示文摘 | Li Qiang Siles J A Thompson I P | 2010 | Appl Microbiol Biotech- nol2010，88，3： | 1 |
| 9 | Classification of foreign fibers in cotton lint using machine vision and multi-class support vector machine显示文摘 | Li Daoliang Yang Wenzhu Wang Sile | 2010 | Computers and Electronics in Agriculture2010，74，2： | 1 |
| 10 | Saliency-based color image segmentation in foreign fiber detection显示文摘 | Yang Wenzhu Li Daoliang Wang Sile | 2013 | Mathematical and Computer Modelling2013，58，3： | 1 |
| 11 | Succinic acid production from orange peel and wheat straw by batch fermentations of Fibrobacter succinogenes $85显示文摘 | LI Q SILES J A THOMPSON I P | 2010 | Appl Microbiol Biotechnol2010，88，3： | 1 |
| 12 | Classifica- tion of foreign fibers in cotton lint using machine vi sion and multi-class support vector machine 显示文摘 | Daoliang Li Wenzhu Yang Sile Wang | 2010 | Computers and Electronics in Agriculture2010，74，2： | 1 |
| 13 | Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats 显示文摘 | Wang Siling Li Dexin Ito Yoshimasa | 2004 | Current Eye Research2004，29，1： | 1 |
| 14 | Mesoporous carbon as a carrier for celecoxib:The improved inhibition effect on MDA-MB-231 cells migration and invasion显示文摘In the current study,mesoporous carbon(MC)with pore volume(1.53 cm3/g)and pore size(9.74 nm)was successfully prepared as a carrier for celecoxib(CEL).Celecoxib was loaded into the pore channels of MC using three different methods:solvent evaporation method,absorption method and physical mixing method.Solid-state characterization methods,such as SEM,TEM,BET,DSC and XRD were used to systematically investigate the process of the drug loading system.Dissolution tests were performed to examine the effects of MC on the release of CEL.Furthermore,the cytotoxicity,wound healing,migration and invasion experiments were carried out to measure the contribution of MC to the anti-tumor metastasis ability of celecoxib on MDA-MB-231 cells.The results showed that CEL could be kept in a non-crystalline state when they were incorporated into the MC using the solvent evaporation method or absorption method.The dissolution rate of CEL released from MCS(Mesoporous carbon e Celecoxib e Solvent evaporation method)and MCA(Mesoporous carbon e Celecoxib e Absorption evaporation method)was all significantly higher than that of pure CEL.The cumulative release for MCS within the 5 min was up to 51.86%.MCS enhanced the inhibitory effect of CEL on the migration and invasion of MDAMB-231 cells. | Wenquan Zhu Qinfu Zhao Xin Zheng Zhiwen Zhang Tongying Jiang Yaping Li Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，2： | 1 |
| 15 | Classification of foreign fibers in cotton lint using machine vision and multi-class support vector machine 显示文摘 | Li Daoliang Yang Wenzhu Wang Sile | 2010 | Computers and Electronics in Agriculture2010，74，2： | 1 |
| 16 | LRRK2 R1398H polymorphism is associated with decreased risk of Parkinson’s disease in a Han Chinese population显示文摘 | Ling Chen Sile Zhang Yanmei Liu Hua Hong Hongxuan Wang Yifan Zheng Hongyan Zhou Jie Chen Wenbiao Xian Yuemei He Jinru Li Zhuolin Liu Zhong Pei Jinsheng Zeng | 2010 | Parkinsonism and Related Disorders2010，，4： | 1 |
| 17 | Autonomous battery-changing system for UAV's lifelong flight显示文摘Unmanned aerial vehicles(UAVs)lifelong flight is essential to accomplish various tasks,e.g.,aerial patrol,aerial rescue,etc.However,traditional UAVs have limited power to sustain their flight and need skilled operators manually control their charging process.Manufacturers and users are eagerly seeking a reliable autonomous battery-changing solution.To address this need,we propose and design an autonomous battery-changing system for UAVs using the theory of inventive problem solving(TRIZ)and user-centered design(UCD)methods.For practical application,we employ UCD to thoroughly analyze user requirements,identify multiple pairs of technical contradictions,and solve these inconsistencies using TRIZ theory.Furthermore,we design an autonomous battery-changing hardware system that meets user requirements and realizes the battery change process after the automatic landing of UAVs.Finally,we conduct experiments to validate our system’s effectiveness.The experimental results show that our battery-changing system can implement the autonomous battery-changing task,and our system has high efficiency and robustness in the real environment. | Jiyang Chen Wenxi Li Yingting Sha Yinchuan Wang Zhenqiang Zhang Shikuan Li Chaoqun Wang Sile Ma | 2023 | Biomimetic Intelligence & Robotics2023，3，2： | 0 |
| 18 | Development of phosphonate-terminated magnetic mesoporous silica nanoparticles for pH-controlled release of doxorubicin and improved tumor accumulation显示文摘In this study,phosphonate-terminated magnetic mesoporous nanoparticles(pMMSNs)was designed by incorporation of MNPs in the center of mesoporous silica nanoparticles(MSNs)and followed by grafting phosphonate group on to the surface of MMSNs.The carrier exhibited a typical superparamagnetic feature and the saturation magnetization was 4.89 emu/g measured by vibrating sample magnetometer(VSM).pMMSNs had a spherical morphology and a pore size of 2.2 nm.FromN2 adsorption-desorption analysis,pMMSNs had a surface area of 613.4 m^(2)/g and a pore volume of 0.78 cm^(3)/g.Phosphonate modification improved the colloidal stability of MMSNs,and the hydrodynamic diameter of pMMSNs was around 175 nm.The hydrophilic phosphonate group significantly enhanced the negative surface charge of MMSNs from -19.3 mV to -28.8 mV pMMSNs with more negative surface charge had a 2.3-fold higher drug loading capacity than that of MMSNs.In addition,the rate and amount of release of doxorubicin(DOX)from DOX/pMMSNs was pH-dependent and increased with the decrease of pH.At pH 7.4,the release amount was quite low and only approximately 17wt%ofDOXwasreleasedin48h.AtpH5.0and3.0,the release rate increased significantly and the release amount achieved 31 wt%and 60 wt%in 48 h,respectively.To evaluate the magnetic targeting performance ofpMMSNs,FITC labeledpMMSNswas injected into mice bearing S180 solid tumor.FITC labeledpMMSNscontrolled by an external magnetic field showed higher tumor accumulation and lower normal tissue distribution. | Erxi Che Long Wan Ying Zhang Qinfu Zhao Xiling Han Jia Li Jia Liu Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 0 |
| 19 | Self-Assembled VS4 Hierarchitectures with Enhanced Capacity and Stability for Sodium Storage显示文摘Sodium-ion batteries(SIBs)have become an auspicious candidate for largescale energy storage by cause of low cost,natural abundance,and similar working principle with lithium-ion batteries(LIBs).At present,there is an urgent need to explore superior anode materials with rapid and stable sodiation/desodiation.Herein,3D self-assembled VS4 curly nanosheets hierarchitectures(VS4-CN-Hs)are developed for SIB anodes,where VS4 possesses a large theoretical sodium storage capacity,and the building block of nanosheets has large exposed surface area to the electrolyte as well as the constructed hierarchitectures can provide abundant buffer space to alleviate the volume expansion.As a result,VS4-CN-Hs anode possesses excellent electrochemical performance under a wide voltage window of 0.01–3.0 V,such as high reversible capacity of 863 mA h g^(−1) at 0.1 A g^(−1),marvelous rate feature(444 mA h g^(−1) at 10 A g^(−1)),and extralong cycle stability(386 mA h g^(−1) after 1000 times at 5 A g^(−1)). | Siling Cheng Kaitong Yao Kunxiong Zheng Qifei Li Dong Chen Yu Jiang Weiling Liu Yuezhan Feng Xianhong Rui Yan Yu | 2022 | Energy & Environmental Materials2022，5，2： | 0 |
| 20 | Incorporation of Carvedilol into PAMAM-functionalized MWNTs as a sustained drug delivery system for enhanced dissolution and drug-loading capacity显示文摘The purpose of this study was to develop poly(amidoamine)(PAMAM)-functionalized multi-walled carbon nanotubes(MWNTs)loaded with a poorly water-soluble drug,intended to improve the drug-loading capacity,dissolution and design a sustained release system.MWNTs were modified with a carboxyl group by acid treatment and then complex with PAMAM.PAMAM-MWNTs were investigated as a scaffold for loading the model drug,Carvedilol(CAR),using three different methods(the fusion method,the incipient wetness impregnation method,and the solvent method).The effects of different pore size,specific surface area and physical state were systematically studied using FT-IR,TGA,SEM,DSC,nitrogen adsorption,XPS and XRD.All the samples made by PAMAM-MWNTs to load the drug had a marked effect on the drug-loading capacity as well as drug dissolution,especially theⅡ-30%. | Xin Zheng Tianyi Wang Haitao Jiang Yuting Li Tongying Jiang Jinghai Zhang Siling Wang | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员