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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | 3D Chromatin Architecture of Large Plant Genomes Determined by Local A/B Compartments显示文摘染色体的空间组织在基因表示的规定起一个重要作用。然而,核心动物染色体的结构的特征例如拓扑地联系的域(男孩) 和染色质环,不在极其紧缩的 Arabidopsis 染色体是突出的。在这研究,我们检验 ? 染色质建筑学,以及他们的 DNA methylation, histone 修正,可存取的染色质,和基因表示玉米,有染色体的西红柿,蜀黍,狐尾稷,和米饭缩放从 0.4 ? 到 2.4 Gb。我们发现这些植物染色体能被划分成象哺乳动物一样 A/B 分隔空间。在更高的分辨率,这些植物的染色体能进一步被划分到反映他们的 euchromatin, heterochromatin,和 polycomb 地位的本地 A/B 分隔空间。在所有这些植物的染色质被组织成没越过种类被保存的领域。他们显示出类似到果蝇分隔空间领域,并且被聚类进活跃, polycomb,压抑、中间的类型基于他们的 transcriptional 活动和 epigenetic 签名,与有本地 A/B 分隔空间连接的领域边阶重叠。在大玉米和西红柿染色体,我们观察了广泛的染色质环。不同于在 TAD 边阶被充实的哺乳动物的染色质环,然而种染色质环经常在压抑的域外面在基因岛之间被形成 ? 并且仔细与活跃分隔空间被联系。我们的学习显示植物有复杂、唯一的 3D 染色质体系结构,它要求 ? 阐明的进一步的学习他们的生物功能。 | Pengfei Dong Xiaoyu Tu Po-Yu Chu Peitao Lu Ning Zhu Donald Grierson Baijuan Du Pinghua Li Silin Zhong | 2017 | Molecular Plant2017，10，12： | 12 |
| 3 | Thermal-responsive genetic and epigenetic regulation of DAM cluster controlling dormancy and chilling requirement in peach floral buds显示文摘The Dormancy-associated MADS-box(DAM)gene cluster in peach serves as a key regulatory hub on which the seasonal temperatures act and orchestrate dormancy onset and exit,chilling response and floral bud developmental pace.Yet,how different temperature regimes interact with and regulate the six linked DAM genes remains unclear.Here,we demonstrate that chilling downregulates DAM1 and DAM3–6 in dormant floral buds with distinct patterns and identify DAM4 as the most abundantly expressed one.We reveal multiple epigenetic events,with tri-methyl histone H3 lysine 27(H3K27me3)induced by chilling specifically in DAM1 and DAM5,a 21-nt sRNA in DAM3 and a ncRNA induced in DAM4.Such induction is inversely correlated with downregulation of their cognate DAMs.We also show that the six DAMs were hypermethylated,associating with the production of 24-nt sRNAs.Hence,the chilling-responsive dynamic of the different epigenetic elements and their interactions likely define distinct expression abundance and downregulation pattern of each DAM.We further show that the expression of the five DAMs remains steadily unchanged or continuously downregulated at the ensuing warm temperature after chilling,and this state of regulation correlates with robust increase of sRNA expression,H3K27me3 and CHH methylation,which is particularly pronounced in DAM4.Such robust increase of repressive epigenetic marks may irreversibly reinforce the chillingimposed repression of DAMs to ensure flower-developmental programming free from any residual DAM inhibition.Taken together,we reveal novel information about genetic and epigenetic regulation of the DAM cluster in peach,which will be of fundamental significance in understanding of the regulatory mechanisms underlying chilling requirement and dormancy release,and of practical application for improvement of plasticity of flower time and bud break in fruit trees to adapt changing climates. | Hong Zhu Pao-Yang Chen Silin Zhong Chris Dardick Ann Callahan Yong-Qiang An Steve van Knocker Yingzhen Yang Gan-Yuan Zhong Albert Abbott Zongrang Liu | 2020 | Horticulture Research2020，7，1： | 9 |
| 4 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 5 | Diversity and redundancy of the ripening regulatory networks revealed by the fruitENCODE and the new CRISPR/Cas9 CNR and NOR mutants显示文摘Tomato is considered as the genetic model for climacteric fruits,in which three major players control the fruit ripening process:ethylene,ripening transcription factors,and DNA methylation.The fruitENCODE project has now shown that there are multiple transcriptional circuits regulating fruit ripening in different species,and H3K27me3,instead of DNA methylation,plays a conserved role in restricting these ripening pathways.In addition,the function of the core tomato ripening transcription factors is now being questioned.We have employed CRISPR/Cas9 genome editing to mutate the SBP-CNR and NAC-NOR transcription factors,both of which are considered as master regulators in the current tomato ripening model.These plants only displayed delayed or partial non-ripening phenotypes,distinct from the original mutant plants,which categorically failed to ripen,suggesting that they might be gain-of-function mutants.Besides increased DNA methylation genome-wide,the original mutants also have hyper-H3K27me3 in ripening gene loci such as ACS2,RIN,and TDR4.It is most likely that multiple genetic and epigenetic factors have contributed to their strong non-ripening phenotypes.Hence,we propose that the field should move beyond these linear and twodimensional models and embrace the fact that important biological processes such as ripening are often regulated by highly redundant network with inputs from multiple levels. | Ying Gao Ning Zhu Xiaofang Zhu Meng Wu Cai-Zhong Jiang Donald Grierson Yunbo Luo Wei Shen Silin Zhong Da-Qi Fu Guiqin Qu | 2019 | Horticulture Research2019，6，1： | 7 |
| 6 | Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration显示文摘Hyperhomocysteinemia (HHcy ) 由增加增长并且在 T 房间刺激 cytokine 分泌物加速动脉粥样硬化。然而, homocysteine (Hcy ) 是否调停了 T 房间激活与新陈代谢的 reprogramming 被联系是不清楚的。这里,我们的在里面 vivo 并且在研究显示出的 vitro,在老鼠的那刺激 Hcy 的脾的 T 房间激活被 mitochondrial 的增加的层次伴随反应的氧种类(ROS ) 和钙, mitochondrial 团和呼吸。禁止 mitochondrial ROS 生产和钙信号或堵住 mitochondrial 呼吸大部分弄钝导致 Hcy 的 T 房间干扰素(IFN-) 分泌物和增长。Hcy 也提高了 endoplasmic 蜂窝胃(嗯) 在 T 房间的应力,和抑制嗯有 4-phenylbutyric 酸的应力堵住了导致 Hcy 的 T 房间激活。机械学地, Hcy 增加了联合,并且解开的嗯线粒体由微导管禁止者 nocodazole 的嗯线粒体在 T 房间稀释了刺激 Hcy 的 mitochondrial reprogramming, IFN- 分泌物和增长,建议那并排嗯并且线粒体为支持 Hcy 的 mitochondrial 被要求功能和 T 房间激活。在结论, Hcy 由增加联合并且调整新陈代谢的 reprogramming 的嗯线粒体支持 T 房间激活。 | Juan Feng Silin Lu Yanhong Ding Ming Zheng Xian Wang | 2016 | Protein & Cell2016，7，6： | 6 |
| 7 | 中国人口生育意愿变迁:1980-2011(英文)显示文摘本文基于1980—2011年间开展的227项关于中国人生育意愿的调查结果,运用横断历史元分析方法,考察了生育意愿的纵向变化趋势。研究发现:1980年以来中国人理想子女数呈减少趋势。2000年之后平均理想子女数基本稳定在1.6—1.8人之间。1980年代中国人生育水平高于生育意愿。随着经济和教育发展水平的提升,二者均呈下降趋势,但是生育水平下降快于生育意愿。1990年之后生育水平低于生育意愿,即人们实际生育子女数少于理想子女数。这为认识生育意愿和生育水平在中国的变化趋势提供了实证依据。 | 侯佳伟 Huang Silin Xin Ziqiang Sun Ling Zhang Hongchuan Dou Donghui Zhao Yuanyuan | 2015 | Social Sciences in China2015，36，1： | 5 |
| 8 | Recent advances in enzyme-mediated peptide ligation显示文摘Artificial synthesis and site-specific modification of peptides and proteins has evolved into an indispensable tool for protein engineers and chemical biologists. Chemical and enzymatic approaches to peptide ligation are important alternatives of recombinant DNA technology for protein synthesis and modification. Although as old as that of chemical procedures, enzyme-mediated peptide ligation is far less developed than that of chemical counterpart due to the difficult availability of peptide ligase.Fortunately, this situation has been changed slowly with the fast development of biological techniques. In the past decades, several natural peptide ligases have been discovered. Protein engineering to improve the ligation efficiencies of the natural peptide ligase and to reverse the functionality of protease provide more powerful peptide ligases. In this review, the advances of enzyme-mediated peptide ligation and their application in protein synthesis and modification will be discussed. | Silin Xu Zhenguang Zhao Junfeng Zhao | 2018 | Chinese Chemical Letters2018，29，7： | 5 |
| 9 | Fast-Suppressor Screening for New Components in Protein Trafficking,Organelle Biogenesis and Silencing Pathway in Arabidopsis thaliana Using DEX-Inducible FREE1-RNAi Plants显示文摘Membrane trafficking is essential for plant growth and responses to external signals.The plant unique FYVE domain-containing protein FREE1 is a component of the ESCRT complex(endosomal sorting complex required for transport).FREE1 plays multiple roles in regulating protein trafficking and organelle biogenesis including the formation of intraluminal vesicles of multivesicular body(MVB),vacuolar protein transport and vacuole biogenesis,and autophagic degradation.FREE1 knockout plants show defective MVB formation,abnormal vacuolar transport,fragmented vacuoles,accumulated autophagosomes,and seedling lethality.To further uncover the underlying mechanisms of FREE1 function in plants,we performed a forward genetic screen for mutants that suppressed the seedling lethal phenotype of FREE1-RNAi transgenic plants.The obtained mutants are termed as suppressors of free1(sof).To date,229 putative sof mutants have been identified.Barely detecting of FREE1 protein with M3plants further identified 84 FREE1-related suppressors.Also145 mutants showing no reduction of FREE1 protein were termed as RNAi-related mutants.Through next-generation sequencing(NGS)of bulked DNA from F2mapping population of two RNAi-related sof mutants,FREE1-RNAi T-DNA inserted on chromosome 1 was identified and the causal mutation of putative sof mutant is being identified similarly.These FREE1-and RNAi-related sof mutants will be useful tools and resources for illustrating the underlying mechanisms of FREE1 function in intracellular trafficking and organelle biogenesis,as well as for uncovering the new components involved in the regulation of silencing pathways in plants. | Qiong Zhao Caiji Gao PoShing Lee Lin Liu Shaofang Li Tangjin Hu Jinbo Shen Shuying Pan Hao Ye Yunru Chen Wenhan Cao Yong Cui Peng Zeng Sheng Yu Yangbin Gao Liang Chen Beixin Mo Xin Liu Shi Xiao Yunde Zhao Silin Zhong Xuemei Chen Liwen Jiang | 2015 | Journal of Genetics and Genomics2015，42，6： | 4 |
| 10 | Comparative WGBS identifies genes that influence non-ripe phenotype in tomato epimutant Colourless non-ripening显示文摘Whole-genome bisulfite sequencing(WGBS)allows single-base resolution and genome-wide profiling of DNA methylation in plants and animals.This technology provides a powerful tool to identify genes that are potentially controlled by dynamic changes of DNA methylation and demethylation.However,naturally occurring epimutants are rare and genes under epigenetic regulation as well as their biological relevances are often difficult to define.In tomato,fruit development and ripening are a complex process that involves epigenetic control.We have taken the advantage of the tomato epimutant Colourless non-ripening(Cnr)and performed comparative mining of the WGBS datasets for the Cnr and Sl CMT3-silenced Cnr fruits.We compared DNA methylation profiles for the promoter sequences of approximately 5,000 bp immediately upstream of the coding region of a list of20 genes.Differentially methylated regions were found for some of these genes.Virus-induced gene silencing(VIGS)of differentially methylated gene Sl DET1 or Sl PDS resulted in unusual brown pigmentation in Cnr fruits.These results suggest that comparative WGBS coupled with VIGS can be used to identify genes that may contribute to the colourless unripe phenotype of fruit in the Cnr epimutant. | Weiwei Chen Zhiming Yu Junhua Kong Hui Wang Yichen Li Mei Zhao Xiaohong Wang Qianqian Zheng Nongnong Shi Pengcheng Zhang Silin Zhong Paul Hunter Mahmut Tor Yiguo Hong | 2018 | Science China(Life Sciences)2018，61，2： | 3 |
| 11 | Minimally invasive perventricular device closure of perimembranous ventricular septal defect without cardiopulmonary bypass: Multicenter experience and mid-term follow-up显示文摘 | Quansheng Xing Silin Pan Qi An Zewei Zhang Jianhua Li Feng Li Qin Wu Zhongyun Zhuang | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，6： | 2 |
| 12 | The silk road economic belt: balance of interests显示文摘The article makes an analogy between the Great Silk Road and the modern Belt and Road Initiative(BRI,also known as‘One Belt,One Road’[OBOR])of China in the context of their significance for the development of international trade,as well as the Central Asian region.The historical role of the Silk Road is considered from the viewpoint of mutual benefit of states along the trade route.The authors consider the concept as the co-development of states,suggested by China within the framework of the BRI,which involves international cooperation on the basis of mutual benefits for all participants,promotion of economic growth and welfare,development of modern infrastructure through joint investments.An attempt is made to assess the interests of Central Asian countries in the Silk Road Economic Belt(SREB)projects.Common interests include construction of modern road infrastructure,exploration and extraction of mineral deposits,transportation of energy resources,establishment of logistics and industrial zones.There is an increase in the transit role of the Central Asian countries within the framework of the BRI,as well an increase in investments from China.The countries along SREB are concerned about potential threats of the inflow of Chinese labour,the use of technologies that can cause environmental problems,the loss of control over strategic assets,and general growth of financial dependence on China.The article analyses Russia’s perception of the Chinese initiative.It is concluded that the main mutual interest of the two countries is opposing the US’s attempts to establish a dominating role in the region and thus ensuring the security of the transport system through the institutions of the Eurasian Economic Union(EAEU)and the Shanghai Cooperation Organisation(SCO).The authors reveal a trend of changing the role of Russia as the main transit corridor for Chinese goods exported to Europe and European ones imported to China.The key long-term economic interests of China implementing the BRI have been identified:expansion of foreign markets,access to critical resources in the countries of Central Asia,export of capital,transfer of production abroad,increased exports of high-tech products and services,expansion of the RMB currency area and initiation of structural changes in the global management system.The assessment of China’s initiative by the US and Europe is given as a claim to economic leadership and the struggle to balance the country’s geopolitical position with its economic strength.The authors identify the areas of mutual and opposing interests of some European countries and China.It is concluded that,despite high risks and existing threats,the projects of the BRI can be implemented successfully that achieve the balance of interests and long-term mutual benefits of the countries involved. | Yakov Silin Larisa Kapustina Italo Trevisan Andrei Drevalev | 2018 | Economic and Political Studies2018，6，3： | 2 |
| 13 | 小麦TaWRKY46-1基因克隆及建立在Gateway技术上的可诱导表达载体的构建显示文摘以小麦品种扬麦158为材料,根据NCBI中小麦TaWRKY46基因序列设计引物,采用RT-PCR技术从小麦总RNA中分离了大小为870 bp的cDNA片段。测序表明,该片段与NCBI中已克隆的小麦TaWRKY46基因高度同源,包含完整的读码框,值得注意的是此蛋白保守氨基酸序列WRKYGQK突变为WRKYGEK,为TaWRKY46的新等位基因,命名为TaWRKY46-1。采用Gateway克隆技术构建了该基因的可诱导型超量表达载体,并转化农杆菌,为接下来转基因验证TaWRKY46-1的功能奠定了基础。 | 李明 丁博 牛有雄 吕芳芳 杨文丽 Silin Zhong 孙守钧 谢晓东 | 2011 | 华北农学报2011，26，2： | 2 |
| 14 | Nuclear expression of survivin is associated with improved survival in metastalie ovarian carcinoma显示文摘 | Kleinberg L Florenes VA Silins I | 2007 | Cancer2007，109，2： | 1 |
| 15 | Nuclear expression of surviving is associated with improved survival in metastatic ovarian carcinoma显示文摘 | Kleinberg L Florenes V A Silin I | 2007 | Cancer2007，109，2： | 1 |
| 16 | Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia显示文摘 | Bellomo D Headrick JP Silins GU | 2000 | Circ Res2000，86，2： | 1 |
| 17 | A population-based study of cervical carcinoma and HPV infection in Latvia 显示文摘 | Silins I Wang X Tadesse A | 2004 | Gynecol Oncol2004，93，2： | 1 |
| 18 | Analysis of chalk petrophysical properties by means of submicron-scale pore imaging and modeling显示文摘 | L Tomutsa D Silin V Radmilovir | | 0，，03： | 1 |
| 19 | Absorption band study on SiO2显示文摘 | Skuja L N Silin A R | 1979 | Physica Status Solidi1979，56，： | 1 |
| 20 | Minimally invasive perventricular device closure of an isolated perimembranous ventricular septal defect with a newly designed delivery sys- tem : preliminary experience 显示文摘 | Quansheng X Silin P Zhongyun Z | 2009 | J Thorac Cardiovasc Surg2009，137，3： | 1 |
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