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| 1 | Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein显示文摘Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein. | Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang Lin Li Shibo Jiang Wei Xu Gengfu Xiao Shuwen Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Chokeberry(Aronia melanocarpa)as a new functional food relationship with health:an overview显示文摘As a consumer product,black chokeberry(Aronia melanocarpa)is diffi cult to consume due to its pungent taste.It is mainly used in various food industries to produce a variety of juices,preserves,extracts,fruit teas and nutritional supplements.Traditionally,Potawatomi Native Americans used black chokeberry to treat colds,coughs and fever.It has been found to contain numerous active ingredients.Currently,there are many health and medical products that contain black chokeberry.The purpose of this review is to understand the nutritional benefi ts of black chokeberry and to explore its benefi cial effects on biological systems in vitro,thereby emphasizing its therapeutic prospects. | Yiwen Zhang Yingchun Zhao Xinglong Liu Xueyan Chen Chuanbo Ding Ling Dong Jinping Zhang Shuwen Sun Qiteng Ding Sadia Khatoom Zhiqiang Cheng Wencong Liu Liqian Shen Fengyan Xiao | 2021 | Journal of Future Foods2021，1，2： | 3 |
| 3 | Approach to the Geopolitical Influences of Great Powers in Southeast Asia: Case Studies of China and the US显示文摘A quantitative approach to the national geopolitical influence is helpful to provide a reference for national sustainable development on the international stage, based on describing national diplomatic capacity and overseas influence. Herein, this study proposes a complex geopolitical influence model, considering the affected nations' response. The geopolitical influences of great power in the affected nation are correlated with overall strength, the acceptance degree of the affected nation to the great power and the distance between both sides. Then, the geopolitical influences of China and the US in Southeast Asia countries are empirically analyzed from 2005 to 2015. The geopolitical influence of China in Southeast Asia has been largely growing for the past decades, accompanying with a constant trend of the US' effects. It is believed that China and the US can coexist peacefully in Southeast Asia to promote the regional development, and jointly create an open, inclusive and balanced regional cooperation architecture that benefits all nations in this region and great powers, through mutual political trust and economic beneficial cooperation. This study may contribute to advancing the policy debate and determining the optimal cooperation in pledging commitment to a new and sustainable model of great power relationship among the various regional geopolitical options. | QIN Qi CHENG Shengkui LI Fei ZHANG Shuwen WU Liang ZHANG Dan | 2019 | Chinese Geographical Science2019，29，2： | 3 |
| 4 | Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation:A novel approach to atherosclerosis therapy显示文摘Toll-like receptor 3(TLR3),as an important pattern recognition receptor(PRR),dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.Atherosclerosis is proved as an inflammatory disease,and inflammatory events involved in the entire process of initiation and deterioration.However,the contribution of TLR3 to atherosclerosis remains unclear.Herein,we identified the clinical relevance of TLR3 upregulation and disease processes in human atherosclerosis.Besides,activation of TLR3 also directly led to significant expression of atherogenic chemokines and adhesion molecules.Conversely,silencing TLR3 inhibited the uptake of oxLDL by macrophages and significantly reduced foam cell formation.Given the aberrance in TLR3 functions on atherosclerosis progression,we hypothesized that TLR3 could serve as novel target for clinical atherosclerosis therapy.Therefore,we developed the novel ellipticine derivative SMU-CX24,which specifically inhibited TLR3(IC_(50)=18.87±2.21 nmol/L).In vivo,atherosclerotic burden was alleviated in Western diet fed ApoE^(−/−)mice in response to SMU-CX24 treatment,accompanying notable reductions in TLR3 expression and inflammation infiltration within atherosclerotic lesion.Thus,for the first time,we revealed that pharmacological downregulation of TLR3 with specific inhibitor regenerated inflammatory environment to counteract atherosclerosis progression,thereby proposing a new strategy and probe for atherosclerosis therapy. | Xiaohong Cen Baoqu Wang Yuqing Liang Yanlin Chen Yu Xiao Shaohua Du Kutty Selva Nandakumar Hang Yin Shuwen Liu Kui Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 5 | Machine learning accelerated calculation and design of electrocatalysts for CO_(2) reduction显示文摘In the past decades,machine learning(ML)has impacted the field of electrocatalysis.Modern researchers have begun to take advantage of ML‐based data‐driven techniques to overcome the computational and experimental limitations to accelerate rational catalyst design.Hence,significant efforts have been made to perform ML to accelerate calculation and aid electrocatalyst design for CO_(2) reduction.This review discusses recent applications of ML to discover,design,and optimize novel electrocatalysts.First,insights into ML aided in accelerating calculation are presented.Then,ML aided in the rational design of the electrocatalyst is introduced,including establishing a data set/data source selection and validation of descriptor selection of ML algorithms validation and predictions of the model.Finally,the opportunities and future challenges are summarized for the future design of electrocatalyst for CO_(2) reduction with the assistance of ML. | Zhehao Sun Hang Yin Kaili Liu Shuwen Cheng Gang Kevin Li Sibudjing Kawi Haitao Zhao Guohua Jia Zongyou Yin | 2022 | SmartMat2022，3，1： | 2 |
| 6 | A missense mutation in the VHYNP motif of a DELLA protein causes a semi-dwarf mutant phenotype in Brassica napus显示文摘 | Chao Liu Jilin Wang Tiandai Huang Fang Wang Fang Yuan Xiaomao Cheng Yan Zhang Shuwen Shi Jiangsheng Wu Kede Liu | 2010 | Theoretical and Applied Genetics2010，，2： | 1 |
| 7 | 3D Porous MXene Aerogel through Gas Foaming for Multifunctional PressureSensor显示文摘The development of smart wearable electronic devices puts forward higher requirements for future flexible electronics. The design of highly sensitive and high-performance flexible pressure sensors plays an important role in promoting the development of flexible electronic devices. Recently, MXenes with excellent properties have shown great potential in the field of flexible electronics. However, the easy-stacking inclination of nanomaterials limits the development of their excellent properties and the performance improvement of related pressure sensors. Traditional methods for constructing 3D porous structures have the disadvantages of complexity, long period, and difficulty of scalability. Here, the gas foaming strategy is adopted to rapidly construct 3D porous MXene aerogels. Combining the excellent surface properties of MXenes with the porous structure of aerogel, the prepared MXene aerogels are successfully used in high-performance multifunctional flexible pressure sensors with high sensitivity (306 kPa^(-1)), wide detection range (2.3 Pa to 87.3 kPa), fast response time (35 ms), and ultrastability (>20,000 cycles), as well as self-healing, waterproof, cold-resistant, and heat-resistant capabilities. MXene aerogel pressure sensors show great potential in harsh environment detection, behavior monitoring, equipment recovery, pressure array identification, remote monitoring, and human-computer interaction applications. | Yongfa Cheng Li Li Zunyu Liu Shuwen Yan Feng Cheng Yang Yue Shuangfeng Jia Jianbo Wang Yihua Gao Luying Li | 2022 | Research2022，，4： | 1 |
| 8 | Thermal degradation kinetics of uncapped and end-capped poly( propylene carbonate)显示文摘 | Peng Shuwen An Yuxian Chen Cheng | 2003 | Polymer Degradation and Stability2003，80，： | 1 |
| 9 | A missense mutation in the VHYNP motif of a DELLA protein causes a semi-dwarf mutant phenotype in Brassica napus显示文摘 | Chao Liu Jilin Wang Tiandai Huang Fang Wang Fang Yuan Xiaomao Cheng Yan Zhang Shuwen Shi Jiangsheng Wu Kede Liu | 2010 | Theoretical and Applied Genetics2010，，2： | 1 |
| 10 | The searching effectiveness of social tagging in museum websites 显示文摘 | Cho Chengwen Yeh Tingkuang Cheng Shuwen | 2012 | Educational Technology & Society2012，15，4： | 1 |
| 11 | 显示文摘 | Peng Shuwen An Yuxian Chen Cheng | 2003 | Polymer Deg- radation and Stability2003，80，1： | 1 |
| 12 | Miscibility and crystallization behavior of poly ( 3-hydroxyvalerate-co- 3-hydroxyvalerate )/poly ( propylene carbonate ) blends 显示文摘 | PENG Shuwen AN Yuxian CHEN Cheng | 2003 | J Appl Polym Sci2003，90，14： | 1 |
| 13 | Thermal degradation kinetics of uncapped and end-capped poly(propylene carbonate)显示文摘 | Peng Shuwen An Yuxian Chen Cheng | 2003 | Polymer Degradation and Stability2003，80，1： | 1 |
| 14 | Nonisothermal crystallization and melting behavior of poly(3-hydroxybutyrate) and maleated poly(3-hydroxybutyrate) 显示文摘 | Cheng C Bin F Shuwen P | 2002 | European Polymer Journal2002，38，8： | 1 |
| 15 | Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure显示文摘Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure.Mesothelial cell loss is an initiating event for peritoneal fibrosis.We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of macrophages.Moreover,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel formation.GSDME deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration failure.Application of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis efficacy.Mechanistically,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone phosphate.These effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose stress.Thus,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis. | Hongxia Ruan Xuejuan Li Lina Zhou Zihan Zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang Qin Feng Zheng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 16 | HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6显示文摘Endocytosis is a crucial cellular process that takes up cargos by enclosing them in membrane-bound vesicles,and transports cargos to different parts of the cell,such as the lysosomes[1].Endocytosis is classified into several mechanistically and morphologically pathways,including clathrin-mediated endocytosis(CME)and caveolae-mediated endocytosis(CavME)[1,2]. | Siyuan Jiang Xiaoqi Han Tihui Liu Ying He Zidong Zhao Tongfeng Liu Shuwen Cheng Jihang Zhang Liqiang Duan Yajuan Liu Tianyou Cheng Yong Liu Qinong Ye Shan Gao | 2024 | Science Bulletin2024，69，2： | 0 |
| 17 | Study of the growth mechanism of a self‑assembled and ordered multi‑dimensional heterojunction at atomic resolution显示文摘Multi-dimensional heterojunction materials have attracted much attention due to their intriguing properties,such as high efciency,wide band gap regulation,low dimensional limitation,versatility and scalability.To further improve the performance of materials,researchers have combined materials with various dimensions using a wide variety of techniques.However,research on growth mechanism of such composite materials is still lacking.In this paper,the growth mechanism of multidimensional heterojunction composite material is studied using quasi-two-dimensional(quasi-2D)antimonene and quasione-dimensional(quasi-1D)antimony sulfde as examples.These are synthesized by a simple thermal injection method.It is observed that the consequent nanorods are oriented along six-fold symmetric directions on the nanoplate,forming ordered quasi-1D/quasi-2D heterostructures.Comprehensive transmission electron microscopy(TEM)characterizations confrm the chemical information and reveal orientational relationship between Sb2S3 nanorods and the Sb nanoplate as substrate.Further density functional theory calculations indicate that interfacial binding energy is the primary deciding factor for the self-assembly of ordered structures.These details may fll the gaps in the research on multi-dimensional composite materials with ordered structures,and promote their future versatile applications. | Zunyu Liu Chaoyu Zhao Shuangfeng Jia Weiwei Meng Pei Li Shuwen Yan Yongfa Cheng Jinshui Miao Lei Zhang Yihua Gao Jianbo Wang Luying Li | 2023 | Frontiers of Optoelectronics2023，16，4： | 0 |
| 18 | Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation显示文摘Toll-like receptor 2(TLR2)mediated macrophages regulate the protective immune response to infectious microorganisms,but the aberrant activation of macrophages often leads to pathological inflammation,including tissue damage.In this study,we identified antagonists of TLR2 by screening2100 natural products and subsequently identified Taspine,an aporphine alkaloid,as an excellent candidate.Furthermore,analysis of the 10 steps chemical synthesis route and structural optimization yielded the Taspine derivative SMU-Y6,which has higher activity,better solubility,and improved drug-feasible property.Mechanistic studies and seq-RNA analysis revealed that SMU-Y6 inhibited TLR2 over other TLRs,hindered the formation of TLR2/MyD88 complex,and blocked the downstream NF-κB and MAPK signaling pathway,thus suppressing the release of inflammatory cytokines.SMU-Y6 could stabilize TLR2 and bind to TLR2 protein with a Kdof 0.18μmol/L.Additionally,SMU-Y6 could efficiently reverse the M1 phenotype macrophage polarization,reduce the production of cytokines as well as infiltration of neutrophiles and alleviate the local inflammation in mice with acute paw edema and colitis.Collectively,we reported the first aporphine alkaloid derivative that selectively inhibits TLR2 with high binding affinity and superior drug-feasible property,thus providing an urgently-needed molecular probe and potential drug candidate for inflammatory and autoimmune disease therapy. | Junjie Yang Yue Pan Xiaoshan Zeng Shuwen Liu Zhipeng Chen Kui Cheng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 19 | One-proton Knockout from ^(16)C at around 240 MeV/u显示文摘One-nucleon knockout reactions have been used to get spectroscopic factor information of unstable nuclei for decadesl[1-4],and a systematic analysis of experiment for intermediate energies of around 80 MeV/u knockout reactions based on the eikonal model indicates a strong isospin asymmetry dependence of the reduction of the extracted spectroscopic strength relative to the shell-model predictionsl[2,3]. | Zhao Yixuan Sun Yazhou Wang Shitao Sun Zhiyu Zhang Xueheng Yan Duo Pang Danyang Ma Peng Yu Yuhong Yue Ke Tang Shuwen Wang Shaoming Fang Fang Sun Yu Cheng Zehui Liu Xiangman Yang Herun Lu Chengui Duan Limin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 20 | Study of structure-property relationship of semiconductor nanomaterials by off-axis electron holography显示文摘As the scaling down of semiconductor devices, it would be necessary to discover the structure-property relationship of semiconductor nanomaterials at nanometer scale. In this review, the quantitative characterization technique off-axis electron holography is introduced in details, followed by its applications in various semiconductor nanomaterials including group IV, compound and two-dimensional semiconductor nanostructures in static states as well as under various stimuli. The advantages and disadvantages of off-axis electron holography in material analysis are discussed, the challenges facing in-situ electron holographic study of semiconductor devices at working conditions are presented, and all the possible influencing factors need to be considered to achieve the final goal of fulfilling quantitative characterization of the structure-property relationship of semiconductor devices at their working conditions. | Luying Li Yongfa Cheng Zunyu Liu Shuwen Yan Li Li Jianbo Wang Lei Zhang Yihua Gao | 2022 | Journal of Semiconductors2022，43，4： | 0 |
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