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| 1 | Correlation of MRI-determined small bowel Crohn’s disease categories with medical response and surgical pathology显示文摘AIM: To determine whether magnetic resonance imaging (MRI) can be used to categorize small bowel Crohn's disease (SB CD) into groups that correlate with response to medical therapy and surgical pathology.METHODS: Data was collected from all patients with MRI evidence of SB CD without significant colonic disease over a 32-mo period. Two radiologists, blinded to clinical findings, evaluated each MRI and grouped them based on bowel wall thickness and wall enhancement. These categories were: (1) 'fibrosis', (2) 'mild segmental hyper-enhancement and mild wall thickening', (3) 'mild segmental hyper-enhancement and marked wall thickening', (4) 'marked segmental transmural hyper-enhancement'. Patient response to additional medical therapy post-MRI was prospectively determined at 8-wk. Non-responders underwent endoscopy and were offered therapeutic endoscopy or surgery. Surgical pathology was assessed against the MRI category. RESULTS: Fifty-five patients were included. Females and category '2' patients were more likely, and patients with luminal narrowing and hold-up less likely, to respond to medical therapy (P < 0.05). Seventeen patients underwent surgery. The surgical pathologicalfindings of fibrosis and the severity of inflammation correlated with the MRI category in all cases.CONCLUSION: Our fi ndings suggest that SB CD can be grouped by the MRI f indings and that these groups are associated with patients more likely to respond to continued medical therapy. The MRI categories also correlated with the presence and level of intestinal inflammation and fibrosis on surgical pathology, and may be of prognostic use in the management of CD patients. | Ian Craig Lawrance Christopher J Welman Peter Shipman Kevin Murray | 2009 | World Journal of Gastroenterology2009，15，27： | 12 |
| 2 | Small bowel MRI enteroclysis or follow through:Which is optimal?显示文摘AIM:To determine if a nasojejunal tube(NJT) is required for optimal examination of enteroclysis and if patients can be examined only in the supine position.METHODS:Data were collected from all patients undergoing small bowel(SB) magnetic resonance imaging(MRI) examination over a 32-mo period.Patients either underwent a magnetic resonance(MR) follow-through(MRFT) or a MR enteroclysis(MRE) in the supine position.The quality of proximal and distal SB distension as well as the presence of motion artefact and image quality were assessed by 2 radiologists.RESULTS:One hundred and fourteen MR studies were undertaken(MRFT-49,MRE-65) in 108 patients in the supine position only.Image artefact was more frequent in MRE than in MRFT(29.2% vs 18.4%) ,but was not statistically significant(P = 0.30) .Adequate distension of the distal SB was obtained in 97.8% of MRFT examinations and in 95.4% of MRE examinations,respectively.Proximal SB distension was,however,less frequently optimal in MRFT than in MRE(P = 0.0036) ,particularly in patients over the age of 50 years(P = 0.0099) .Image quality was good in all examinations.CONCLUSION:All patients could be successfully imaged in the supine position.MRE and MRFT are equivalent for distal SB distension and artefact effects.Proximal SB distension is frequently less optimal in MRFT than in MRE.MRE is,therefore,the preferred MR examination method of the SB. | Ian C Lawrance Christopher J Welman Peter Shipman Kevin Murray | 2009 | World Journal of Gastroenterology2009，15，42： | 7 |
| 3 | Metabolic syndrome:A review of the role of vitamin D in mediating susceptibility and outcome显示文摘Despite the well-recognised role of vitamin D in a wide range of physiological processes,hypovitaminosis is common worldwide(prevalence 30%-50%) presumably arising from inadequate exposure to ultraviolet radiation and insufficient consumption.While generally not at the very low levels associated with rickets,hypovitaminosis D has been implicated in various very different,pathophysiological processes.These include putative effects on the pathogenesis of neoplastic change,inflammatory and demyelinating conditions,cardiovascular disease(CVD) and diabetes.This review focuses on the association between hypovitaminosis D and the metabolic syndrome as well as its component characteristics which are central obesity,glucose homeostasis,insulin resistance,hypertension and atherogenic dyslipidaemia.We also consider the effects of hypovitaminosis D on outcomes associated with the metabolic syndrome such as CVD,diabetes and non-alcoholic fatty liver disease.We structure this review into 3 distinct sections; the metabolic syndrome,vitamin D biochemistry and the putative association between hypovitaminosis D,the metabolic syndrome and cardiovascular risk. | Richard C Strange Kate E Shipman Sudarshan Ramachandran | 2015 | World Journal of Diabetes2015，6，7： | 5 |
| 4 | Herniation pits of the femoral neck显示文摘 | Pitt MJ Graham AR Shipman JH | 1982 | AJR1982，138，： | 1 |
| 5 | Risk factors for postpartum depression:a retrospective investigation at 4-weeks postnatal and a review of the literature显示文摘 | Mccoy S J Beal J M Shipman S B | 2006 | J Am Osteopath Assoc2006，106，4： | 1 |
| 6 | Role of osteoprotegerin(OPG) in cancer显示文摘 | Holen I Shipman CM | 2006 | Clin Sd (Lond)2006，110，3： | 1 |
| 7 | Role of osteoprotegerin(OPG) in cancer显示文摘 | Shipman CM | 2006 | Clin Sci(Lond)2006，110，3： | 1 |
| 8 | Osteoprotegerin is a soluble decoy reeeptor for tumor necrosis factor related apop- tosis inducing ligand/Ap02 ligand and can function as a paraerine survival factor for human myeloma cells显示文摘 | Shipman CM Croueher PI | 2003 | Cancer Res2003，63，5： | 1 |
| 9 | Toxic myocarditis: report of a case arising from ingestion of liquid plastic catalyst 显示文摘 | Dines DE Shipman K | 1962 | Angiology1962，13，： | 1 |
| 10 | ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS Development显示文摘 | Roberta Sottocornola Christophe Royer Virginie Vives Luca Tordella Shan Zhong Yihua Wang Indrika Ratnayaka Mark Shipman Amanda Cheung Carles Gaston-Massuet Patrizia Ferretti Zoltán Molnár Xin Lu | 2010 | Developmental Cell2010，，1： | 1 |
| 11 | Least-squares two-dimensional phase unwrapping using FFT's 显示文摘 | Pritt M D Shipman J S | 1994 | IEEE Trans Geosci Remote Sens1994，32，3： | 1 |
| 12 | The Health Information Literacy Research Project显示文摘 | SHIPMAN J P | 2009 | J Med Libr Assoc2009，97，4： | 1 |
| 13 | Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes 显示文摘 | STEMKE-HALE K SHIPMAN K KITSOU-MYLONA I | 2013 | Modern Pathol2013，26，4： | 1 |
| 14 | Building and maintaining a library Gopher:traditional skills applied to emerging resources显示文摘 | Riley R A Shipman B L | | 0，，： | 1 |
| 15 | A three-dimensional model to analyzedrug-drug interactions显示文摘 | PRICHARD M SHIPMAN J C | 1990 | Antiviral Research1990，14，： | 1 |
| 16 | Adenocarcinoma in situ and early invasive adenocarcinoma of the uterine cervix显示文摘 | SHIPMAN SD BRISTOW RE | 2001 | Curr Opin Oncol2001，13，5： | 1 |
| 17 | 显示文摘 | Croucher PI Shipman CM Lippitt J | 2001 | Blood2001，98，： | 1 |
| 18 | Screening for devel- opmental dysplasia of hip: a systematic Literature review for the US Preventive Services Task Force 显示文摘 | Shipman SA H elf and M Moyer VA et a l | 2006 | Pediatrics2006，117，3： | 1 |
| 19 | Herniation pit of the femoral neck显示文摘 | Pitt M J Graham AR Shipman JH | | 0，，05： | 1 |
| 20 | Rac activation by the T-cell receptor inhibits T cell migration 显示文摘 | Cernuda-Moroll6n E MillOn J Shipman M | 2010 | PLoS One2010，5，12： | 1 |
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