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| 1 | Regulatory T cells in cancer immunotherapy显示文摘表示 FOXP3 规章的 T (Treg ) 房间,对自我抗原压制异常有免疫力的反应,也压制反肿瘤免疫者反应。进肿瘤纸巾的很多 Treg 房间的渗入经常与差的预后被联系。正在积累 Treg 房间的移动能唤起并且提高反肿瘤免疫者反应的证据。然而, Treg 房间的全身的弄空可以并发地得到有害 autoimmunity。为没有 autoimmunity,唤起有效肿瘤免疫的一策略是明确地严重地指向区分的受动器 Treg 房间而非所有 FOXP3 + T 房间,因为受动器 Treg 房间是在肿瘤纸巾的占优势的房间类型。各种各样的房间表面分子包括象 CCR4 那样的 chemokine 受体,那被受动器 Treg 房间明确地表示能是弄空的候选人由特定的弄空房间的 monoclonal 抗体的受动器 Treg 房间。另外,受动器 Treg 房间的另外的免疫学的特征例如他们 CTLA-4,活跃增长,和 apoptosis 容易的趋势的高表达式,能被利用明确地控制他们的函数。例如, anti-CTLA-4 抗体可以杀死受动器 Treg 房间或稀释他们的镇压活动。这被希望指向的 Treg 房间的联合(例如,由减少 Treg 房间或 attenuating 他们在肿瘤纸巾的镇压活动) 与肿瘤特定的受动器 T 房间的激活(例如,由疫苗的癌症或有免疫力的检查点封锁) 将使当前的癌症免疫疗法更有效。 | Atsushi Tanaka Shimon Sakaguchi | 2017 | Cell Research2017，27，1： | 107 |
| 2 | Non-invasive diagnosis of liver fibrosis and cirrhosis显示文摘The evaluation and follow up of liver fibrosis and cirrhosis have been traditionally performed by liver biopsy. However, during the last 20 years, it has become evident that this 'gold-standard' is imperfect; even according to its proponents, it is only 'the best' among available methods. Attempts at uncovering non-invasive diagnostic tools have yielded multiple scores, formulae, and imaging modalities. All are better tolerated, safer, more acceptable to the patient, and can be repeated essentially as often as required. Most are much less expensive than liver biopsy. Consequently, their use is growing, and in some countries the number of biopsies performed, at least for routine evaluation of hepatitis B and C, has declined sharply. However, the accuracy and diagnostic value of most, if not all, of these methods remains controversial. In this review for the practicing physician, we analyze established and novel biomarkers and physical techniques. We may be witnessing in recent years the beginning of the end of the first phase for the development of non-invasive markers. Early evidence suggests that they might be at least as good as liver biopsy. Novel experimental markers and imaging techniques could produce a dramatic change in diagnosis in the near future. | Yoav Lurie Muriel Webb Ruth Cytter-Kuint Shimon Shteingart Gerardo Z Lederkremer | 2015 | World Journal of Gastroenterology2015，21，41： | 36 |
| 3 | Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases显示文摘Naturally arising regulatory CD4^+T(Treg)cells,which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface,are a T-cell subpopulation specialized for immune suppression,playing a key role in maintaining immunological self-tolerance and homeostasis.FoxP3 is required for Treg function,especially for its suppressive activity.However,FoxP3 expression per se is not necessary for Treg cell lineage commitment in the thymus and insufficient for full Treg-type gene expression in mature Treg cells.It is Treg-specific epigenetic changes such as CpG demethylation and histone modification that can confer a stable and heritable pattern of Treg type gene expression on developing Treg cells in a FoxP3-independent manner.Anomalies in the formation of Treg-specific epigenome,in particular,Treg-specific super-enhancers,which largely include Tregspecific DNA demethylated regions,are indeed able to cause autoimmune diseases in rodents.Furthermore,in humans,single nucleotide polymorphisms in Treg-specific DNA demethylated regions associated with Treg signature genes,such as IL2RA(CD25)and CTLA4,can affect the development and function of naive Treg cells rather than effector T cells.Such genetic variations are therefore causative of polygenic common autoimmune diseases including type 1 diabetes and rheumatoid arthritis via affecting endogenous natural Treg cells.These findings on the transcription factor network with FoxP3 at a key position as well as Tregspecific epigenetic landscape facilitate our understanding of Treg cell development and function,and can be exploited to prepare functionally stable FoxP3-expressing Treg cells from antigen-specific conventional T cells to treat autoimmune diseases. | Naganari Ohkura Shimon Sakaguchi | 2020 | Cell Research2020，30，6： | 29 |
| 4 | Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance显示文摘AIM: To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance. METHODS: Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneousHBsAg seroclearance.HBsAg seroclearance. RESULTS: Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (>35 years) OR = 1.7 (95%CI: 1.25-2.8, P=0.05), serum vitamin D levels (>20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P=0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P=0.02), low viral load (hepatitis B virus DNA < 100 IU/mL) OR = 3 (95%CI: 2.6-4.2, P = 0.01) and duration of HBsAg seropositivity (> 8 years) OR = 1.6 (95%CI: 1.15-2.6, P=0.04) were also associated with spontaneous HBsAg seroclearance. CONCLUSION: We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance. | Mahmud Mahamid William Nseir Omar Abu Elhija Shimon Shteingart Ammad Mahamid Mosab Smamra Benjamin Koslowsky | 2013 | World Journal of Hepatology2013，5，6： | 14 |
| 5 | Success of acupuncture treatment in patients with initially low sperm output is associated with a decrease in scrotal skin temperature显示文摘Poor spermatogenesis in patients with inflammation of the genital tract is associated with scrotal hyperthermia.These patients can benefit from acupuncture treatment.We conducted a study to verify whether the influence of acupuncture treatment on sperm output in patients with low sperm density is associated with a decrease in scrotal temperature.The experimental group included 39 men who were referred for acupuncture owing to low sperm output.The control group,which comprised 18 normal fertile men,was used to define a threshold(30.5℃)above which scrotal skin temperature was considered to be high.Accordingly,34 of the 39 participants in the experimental group initially had high scrotal skin temperature;the other five had normal values.Scrotal skin temperature and sperm concentration were measured before and after acupuncture treatment.The five patients with initially normal scrotal temperatures were not affected by the acupuncture treatment.Following treatment,17 of the 34 patients with hyperthermia,all of whom had genital tract inflammation,had normal scrotal skin temperature;in 15 of these 17 patients,sperm count was increased.In the remaining 17 men with scrotal hyperthermia,neither scrotal skin temperature nor sperm concentration was affected by the treatment.About 90%of the latter patients suffered from high gonadotropins or mixed etiological factors.Low sperm count in patients with inflammation of the genital tract seems to be associated with scrotal hyperthermia,and,consequently,acupuncture treatment is recommended for these men. | Shimon Siterman Fina Eltes Liora Schechter Yair Maimon Hanny Lederman Benjamin Bartoov | 2009 | Asian Journal of Andrology2009，11，2： | 8 |
| 6 | Trabeculectomy with Ex-PRESS implant versus Ahmed glaucoma valve implantation-a comparative study显示文摘AIM:To compare the surgical outcomes of trabeculectomy with Ex-PRESS implant and Ahmed glaucoma valve(AGV) implantation. METHODS: Patients who underwent trabeculectomy with Ex-PRESS implants or AGV implantation separately were included in this retrospective chart review.Main outcome measures were surgical failure and complications.Failure was defined as intraocular pressure(IOP) >21 mm Hg or <5 mm Hg on two consecutive visits after 3mo,reoperation for glaucoma,or loss of light perception.Eyes that had not failed were considered as complete success if they did not required supplemental medical therapy.RESULTS: A total of 64 eyes from 57 patients were included: 31 eyes in the Ex-PRESS group and 33 eyes in the AGV group.The mean follow-up time was 2.6 ±1.1y and 3.3±1.6y,respectively.Patients in the AGV group had significantly higher baseline mean IOP(P =0.005),lower baseline mean visual acuity(VA)(P =0.02),and higher proportion of patients with history of previous trabeculectomy(P <0.0001).Crude failure rates were 16.1%,n =5/31 in the Ex-PRESS group and 24.2%,n =8/33 in the AGV group.The cumulative proportion of failure was similar between the groups,P =0.696.The proportion of eyes that experienced postoperative complications was32.3% in the Ex-PRESS group and 60.1% in the AGV group(P =0.0229).CONCLUSION: Trabeculectomy with Ex-PRESS implant and AGV implantation had comparable failure rates.The AGV group had more post-operative complications,but also included more complex cases with higher baselinemean IOP,worse baseline mean VA,and more previous glaucoma surgeries.Therefore,the results are limited to the cohort included in this study. | Michael Waisbourd Naomi Fischer Hadas Shalev Oriel Spierer Elad Ben Artsi Rony Rachmiel Gabi Shemesh Shimon Kurtz | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 6 |
| 7 | Etiology and long-term outcome of extrahepatic portal vein obstruction in children显示文摘AIM:To study the management and outcome of children with extrahepatic portal vein obstruction(EHPVO) in a whole country population.METHODS:A nationwide multicenter retrospective case series of children with EHPVO was conducted.Data on demographics,radiographic studies,laboratory workup,endoscopic and surgical procedures,growth and development,were extracted from the patients' charts.Characteristics of clinical presentation,etiology of EHPVO,management and outcome were analyzed.RESULTS:Thirty patients,13 males and 17 females,19(63.3%) Israeli and 11(36.7%) Palestinians,were included in the analysis.Age at presentation was 4.8± 4.6 years,and mean follow-up was 4.9±4.3 years.Associated anomalies were found in 4 patients.The incidence of EHPVO in Israeli children aged 0-14 years was 0.72/million.Risk factors for EHPVO were detected in 13(43.3%)patients,including 9 patients(30%) with perinatal risk factors,and 4 patients(13.3%) with prothrombotic states:two had low levels of protein S and C,one had lupus anticoagulant,and one was homozygous for methyltetrahydrofolate reductase mutations.In 56.6% of patients,no predisposing factors were found.The most common presenting symptoms were an incidental finding of splenomegaly(43.3%),and upper gastrointestinal bleeding(40%).No differences were found between Israeli and Palestinian children with regard to age at presentation,etiology and clinical symptoms.Bleeding occurred in 18 patients(60%),at a median age of 3 years.Sclerotherapy or esophageal banding was performed in 20 patients.No sclerotherapy complications were reported.Portosystemic shunts were performed in 11 patients(36.6%),at a median age of 11(range 3-17)years:splenorenal in 9,mesocaval in 1,and a meso-Rex shunt in 1 patient.One patient underwent splenectomy due to severe pancytopenia.Patients were followed up for a median of 3(range 0.5-15)years.One patient died aged 3 years due to mucopolysaccharidase deficiency type Ⅲ.None of the patients died due to gastrointestinal bleeding.CONCLUSION:EHPVO is a rare disorder.The etiological factors are still mostly unknown,and the endoscopic and surgical treatment options ensure a good long-term prognosis. | Batia Weiss Eyal Shteyer Asaf Vivante Drora Berkowitz Shimon Reif Zvi Weizman Yoram Bujanover Rivka Shapiro | 2010 | World Journal of Gastroenterology2010，16，39： | 6 |
| 8 | 香石竹花瓣对乙烯的敏感性与蛋白质合成(英文)显示文摘基因转录抑制剂α-amanitin和蛋白质合成抑制剂cycloheximide完全抑制了香石竹(Dianthuscaryophyllus L.cvs.White Sim and Sandrosa)花瓣对乙烯反应的症状,包括花瓣卷曲和细胞膜离子渗漏增加。观察到花中蛋白质合成能力随着花的衰老而降低,花对乙烯的敏感性随花的衰老而增加。但是用乙烯合成抑制剂aminooxyacetic acid(AOA)预处理切花,则改变了花对乙烯敏感性的变化趋势。常用的香石竹品种D.caryophyllus L.cv.White Sim花经AOA处理后,对乙烯的敏感性随着花的衰老而下降。这些结果揭示花对乙烯的敏感性可能受蛋白质合成能力影响。 | 姜微波 Shimon Mayak Abraham H.Halevy | 1997 | Acta Botanica Sinica1997，39，11： | 4 |
| 9 | Development and Maintenance of Regulatory T cells显示文摘 | Naganari Ohkura Yohko Kitagawa Shimon Sakaguchi | 2013 | Immunity2013，，3： | 4 |
| 10 | Regulatory T Cells and Immune Tolerance显示文摘 | Shimon Sakaguchi Tomoyuki Yamaguchi Takashi Nomura Masahiro Ono | 2008 | Cell2008，，5： | 4 |
| 11 | Nonlinear,tunable,and active optical metasurface with liquid film显示文摘Optical metamaterials and metasurfaces,which emerged in the course of the last few decades,have revolutionized our understanding of light and light–matter interaction.While solid materials are naturally employed as key building elements for construction of optical metamaterials mainly due to their structural stability,practically no attention was given to study of liquid-made optical two-dimensional(2-D)metasurfaces and the underlying interaction regimes between surface optical modes and liquids.We theoretically demonstrate that surface plasmon polaritons and slab waveguide modes that propagate within a thin liquid dielectric film trigger optical self-induced interaction facilitated by surface tension effects,which leads to the formation of 2-D optical liquid-made lattices/metasurfaces with tunable symmetry and can be leveraged for tuning of lasing modes.Furthermore,we show that the symmetry breaking of the 2-D optical liquid lattice leads to phase transition and tuning of its topological properties,which allows the formation,destruction,and movement of Dirac-points in the k-space.Our results indicate that optical liquid lattices support extremely low lasing threshold relative to solid dielectric films and have the potential to serve as configurable analogous computation platform. | Shimon Rubin Yeshaiahu Fainman | 2019 | Advanced Photonics2019，1，6： | 3 |
| 12 | Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats显示文摘 | Shimon Amemiya Tatsushi Kamiya Chikako Nito Toshiki Inaba Kengo Kato Masayuki Ueda Kuniko Shimazaki Yasuo Katayama | 2005 | European Journal of Pharmacology2005，，2： | 3 |
| 13 | 监测喷射混凝土的硬化和强度发展的一种新方法(英文)显示文摘提出了一种新的监测喷射混凝土硬化和强度发展的方法。该方法在'Modiin-Jerusalem'铁路隧道建设工程中得到了实际应用。其最初目的是用来预测评估混凝土的拆模时间。基于直接测量混凝土构件中的电阻率和温度的发展,估测了隧道结构中混凝土的硬化和强度发展。通过组合分析电阻率和温度的发展曲线,构建了一个通用的'强度--电阻率'关系,并依此开发了用于监测早龄期(24h内)喷射混凝土的硬化和强度发展的算法。这个算法可以用于估算混凝土构件达到一定强度所需要的时间,也可用于评估混凝土搅拌站供应到施工现场的混凝土的性能稳定性。 | David STACKELBERG Boris WILGE Shimon BOIKO | 2014 | 硅酸盐学报2014，42，5： | 3 |
| 14 | 决定真正的成本——为什么可再生能源电力比以前所认为的更具成本竞争力?显示文摘 | Shimon Awerbuch 赵建达 朱效章 | 2004 | 小水电2004，，3： | 3 |
| 15 | Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses显示文摘 | Shimon Sakaguchi | 2004 | Annual Review of Immunology2004，，： | 2 |
| 16 | Evolved to adapt: A computational approach to animal innovation and creativity显示文摘 | Oren KOLODNY Shimon EDELMAN Arnon LOTEM | 2015 | Current Zoology2015，61，2： | 2 |
| 17 | The Presence of Foxp3 Expressing T Cells Within Grafts of Tolerant Human Liver Transplant Recipients显示文摘 | Ying Li Xiangdong Zhao Donghua Cheng Hironori Haga Tatsuaki Tsuruyama Kathryn Wood Shimon Sakaguchi Koichi Tanaka Shinji Uemoto Takaaki Koshiba | 2008 | Transplantation2008，，12： | 2 |
| 18 | The Tomato Hybrid Proline-rich Protein regulates the abscission zone competence to respond to ethylene signals显示文摘The Tomato Hybrid Proline-rich Protein(THyPRP)gene was specifically expressed in the tomato(Solanum lycopersicum)flower abscission zone(FAZ),and its stable antisense silencing under the control of an abscission zone(AZ)-specific promoter,Tomato Abscission Polygalacturonase4,significantly inhibited tomato pedicel abscission following flower removal.For understanding the THyPRP role in regulating pedicel abscission,a transcriptomic analysis of the FAZ of THyPRP-silenced plants was performed,using a newly developed AZ-specific tomato microarray chip.Decreased expression of THyPRP in the silenced plants was already observed before abscission induction,resulting in FAZ-specific altered gene expression of transcription factors,epigenetic modifiers,post-translational regulators,and transporters.Our data demonstrate that the effect of THyPRP silencing on pedicel abscission was not mediated by its effect on auxin balance,but by decreased ethylene biosynthesis and response.Additionally,THyPRP silencing revealed new players,which were demonstrated for the first time to be involved in regulating pedicel abscission processes.These include:gibberellin perception,Ca2+-Calmodulin signaling,Serpins and Small Ubiquitin-related Modifier proteins involved in post-translational modifications,Synthaxin and SNARE-like proteins,which participate in exocytosis,a process necessary for cell separation.These changes,occurring in the silenced plants early after flower removal,inhibited and/or delayed the acquisition of the competence of the FAZ cells to respond to ethylene signaling.Our results suggest that THyPRP acts as a master regulator of flower abscission in tomato,predominantly by playing a role in the regulation of the FAZ cell competence to respond to ethylene signals. | Srivignesh Sundaresan Sonia Philosoph-Hadas Chao Ma Cai-Zhong Jiang Joseph Riov Raja Mugasimangalam Betina Kochanek Shoshana Salim Michael SReid Shimon Meir | 2018 | Horticulture Research2018，5，1： | 2 |
| 19 | Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats显示文摘 | Shimon Amemiya Tatsushi Kamiya Chikako Nito Toshiki Inaba Kengo Kato Masayuki Ueda Kuniko Shimazaki Yasuo Katayama | 2005 | European Journal of Pharmacology2005，，2： | 2 |
| 20 | Requirement of Protocol Biopsy Before and After Complete Cessation of Immunosuppression After Liver Transplantation显示文摘 | Mami Yoshitomi Takaaki Koshiba Hironori Haga Ying Li Xiangdong Zhao Donghua Cheng Aya Miyagawa Hiromi Sakashita Tatsuaki Tsuruyama Hidenori Ohe Mikiko Ueda Shinya Okamoto Hiroto Egawa Kathryn Wood Shimon Sakaguchi Toshiaki Manabe Koichi Tanaka Shinji Uemo | 2009 | Transplantation2009，，4： | 2 |
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