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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Self-Compensating Displacement Sensor Based on Hydramatic Structured Transducer and Fiber Bragg Grating显示文摘有为同时的排水量和温度测量的一个大测量范围的一个光纤维排水量传感器在这份报纸被介绍。我们基于活塞和 hydraumatic 结构开发了一个特定的变换器认识到大排水量大小,它把大测量范围和高精确合为一个单个传感器系统。光谱显示出过去常补偿的二座思考山峰在排水量察觉跨敏感。这个排水量传感器能线性地与 0.036 nm/mm 的高敏感在比 45 公里大的一个大测量排水量范围工作。我们报导了的传感器能为即时排水量在象监视的机械形状或液体水平那样的许多工业环境监视被开发。 | Shimeng CHEN Yun LIU Xiuxin LIU Yang ZHANG Wei PENG | 2015 | Photonic Sensors2015，5，4： | 5 |
| 3 | Skeletal intramyocellular lipid metabolism and insulin resistance显示文摘 | Yiran Li Shimeng Xu Xuelin Zhang Zongchun Yi Simon Cichello | 2015 | Biophysics Reports2015，1，2： | 4 |
| 4 | Influence of Al addition on solidification path and hot tearing susceptibility of Mg-2Zn-(3+0.5 x)Y-x Al alloys显示文摘Hot tearing susceptibility(HTS)of Mg-2Zn-(3+0.5 x)Y-x Al(x=0,2 and 3 at%)alloys is predicted by using modified Clyne-Davies’model(CSC^(∗)).The solidification path,solidification characteristic temperatures and dendritic coherency solid fraction have been studied by double-thermocouple thermal analysis.The solidification contraction stress vs.temperature(and time)curves are measured by using a“T”type hot tearing permanent-mold.The results reveal that the CSC^(∗)prediction values are in good agreement with the experimental results.Moreover,Al_(2)Y phase acts as the heterogeneous nucleation core ofα-Mg and significantly influences the grain size.It has been observed that minimum grain size,optimal dendritic coherency and minimum HTS are exhibited by Mg-2Zn-(3+0.5 x)Y-x Al alloy(x=2).Furthermore,when Al content was increased to 3 at%,Al_(2)Y phase exhibited a peritectic reaction and transformed into a mixed structure of Al_(2)Y and Al+Al_(3)Y phases,which increased the HTS of the alloy due to reduced fine-grained Al_(2)Y content. | Guojia Zhang Yue Wang Zheng Liu Shimeng Liu | 2019 | Journal of Magnesium and Alloys2019，7，2： | 4 |
| 5 | Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles显示文摘Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to demineralization.There is an urgent need to develop new therapeutic materials with remineralization functions.This article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).PAMAM was excellent nucleation template,and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization.NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities.PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates,superior acidneutralization,and ions release.Therefore,the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone.PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions.Besides,the long-term remineralization capability of PAMAM+NACP was established.After prolonged fluid challenge,the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration.Furthermore,the hardness of predemineralized dentin was increased back to that of healthy dentin,indicating a complete remineralization.Therefore,the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization,hardness increase,and caries-inhibition capabilities. | Kunneng Liang Suping Wang Siying Tao Shimeng Xiao Han Zhou Ping Wang Lei Cheng Xuedong Zhou Michael D.Weir Thomas W.Oates Jiyao Li Hockin H.K.Xu | 2019 | International Journal of Oral Science2019，11，3： | 3 |
| 6 | Deformation mechanism of fine grained Mg-7Gd-5Y-l.2Nd-0.5Zr alloy under high temperature and high strain rates显示文摘Fine grained Mg-7Gd-5Y-1.2Nd-0.5Zr alloy was investigated by dynamic compression tests using a Split Hopkinson Pressure Bar under the strain rates in the range 1000-2000 s^(-1) and the temperature range 293-573 K along the normal direction.The microstructure was measured by optical microscopy,electron back-scattering diffraction,transmission electron microscopy and X-ray diffractometry.The results showed that Mg-7Gd-5Y-1.2Nd-0.5Zr alloy had the positive strain rate strengthening effect and thermal softening effect at high temperature.The solid solution of Gd and Y atoms in Mg-7Gd-5Y-1.2Nd-0.5Zr alloy reduced the asymmetry of α-Mg crystals and changed the critical shear stress of various deformation mechanisms.The main deformation mechanisms were prismatic slip and pyramidal(a)slip,{102}tension twinning,and dynamic recrystallization caused by local deformation such as particle-stimulated nucleation.c 2020 Published by Elsevier B.V.on behalf of Chongqing University. | Wanru Tang Zheng Liu Shimeng Liu Le Zhou Pingli Mao Hui Guo Xiaofang Sheng | 2020 | Journal of Magnesium and Alloys2020，8，4： | 2 |
| 7 | p53-dependent upregulation of PIG3 transcription by γ-ray irradiation and its interaction with KAP1 in responding to DNA damage显示文摘PIG3 (p53-inducible gene 3), originally identified as one of a set of genes induced by p53 before the onset of apoptosis, was assumed to contribute to early cellular response to DNA damage. Here, we studied the relation between p53 status and the increased expression of PIG3 by ionizing radiation (IR), and the related clues regarding the involvement of PIG3 in the cellular response to IR-induced DNA damage signaling. We demonstrated that the pentanucleotide microsatellite sequence was responsible for the p53-dependent induction of PIG3 transcription after irradiation, while sequence upstream of PIG3 promoter could maintain the basal level of expression which was not inducible by irradiation. The interaction of PIG3 and the KRAB-ZFP-associated protein 1 (KAP1), a DNA damage response protein, was revealed. PIG3 nucleus foci were formed 15 min after γ-ray irradiation, and which were found to partially colocalize with the phospho-KAP-1 foci as well as γ-H2AX foci. Although the lac operator tagged EGFP based reporter system revealed that PIG3 does not remodel chromatin in large scale in the cells under normal growing condition, it indeed prompted the chromatin relaxation in the cellular response to DNA damage signaling. All these data suggest that PIG3 is involved in IR-induced DNA damage response, and which maybe partially attribute to its interaction with KAP1. | QIN Xia ZHANG ShiMeng LI Bingi LIU XiaoDan HE XingPeng SHANG ZengFu XU QinZhi ZHAO ZengQiang YE QiNong ZHOU PingKun | 2011 | Chinese Science Bulletin2011，56，30： | 2 |
| 8 | Technological Exploration of RRAM Crossbar Array for Matrix-Vector Multiplication显示文摘矩阵向量增加是为许多计算地集中的算法的关键操作。抵抗切换的随机的存取存储器(RRAM ) 设备和 RRAM 闩穿的新兴的金属氧化物表明了模拟矩阵向量增加的一条有希望的硬件认识与超离频精力效率。在这篇论文,我们分析设备水平和电路水平的影响非理想的因素包括 RRAM 设备的非线性的当前电压的关系,设备制造的变化并且给操作,和 interconnect 抵抗以及另外的闩数组写参数。在那上,我们建议工艺的探索流动让设备参数配置克服非理想的因素的影响并且为各特定的申请在性能,精力,和可靠性之中完成一宗更好的交易。我们向量机器(SVM ) 和混合公民标准和技术(MNIST ) 模式识别数据集开创的支持的模拟结果证明那个 RRAM 闩数组基于 SVM 是柔韧的输入信号变化但是对通道差距偏差敏感。进一步的抵抗决定测试一台 6 位的 RRAM 设备对有能力的礼品在 90% 附近认识到识别精确性,显示 RRAM 闩数组的物理可行性基于 SVM。另外,建议工艺的探索流动能与以前的工作相比在 MNIST 数据集和 26.4% 精力积蓄上完成识别精确性的 10.98% 改进。试验性的结果也证明节省的超过 84.4% 力量能以很少精确性减小的成本被完成。 | Lixue Xia Peng Gu Boxun Li Tianqi Tang Xiling Yin Wenqin Huangfu Shimeng Yu Yu Cao Yu Wang Huazhong Yang | 2016 | Journal of Computer Science & Technology2016，31，1： | 2 |
| 9 | Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring显示文摘Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also adulthood.However,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely unknown.Therefore,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later life.Methods:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in plasma.The digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW pigs.Results:The rate of portal venous blood flow did not differ beween IUGR and NBW pigs.Plasma concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW pigs.The ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW pigs.IUGR increased hindgut microbial diversity and bacterial fermentation activity in the caecum.In vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal inocula.Conclusion:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing phase.These findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions. | Tiantian Li Shimeng Huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 10 | Dynamic changes of postprandial plasma metabolites after intake of corn-soybean meal or casein-starch diets in growing pigs显示文摘Background: Postprandial nutrients utilization and metabolism of a certain diet is a complicated process. The metabolic feature of pigs after intake of corn-soybean meal or casein-starch diets are largely unknown. Therefore,this study was conducted to investigate the dynamic postprandial changes of plasma metabolic profile using growing pigs using metabolomics.Methods: Twenty-four growing pigs with average initial body weight(BW) about 30 kg were placed in metabolic cages and then fitted with precaval vein catheters. Pigs were fed daily 4% of initial body weight. Two experimental diets were included:(i) a starch-casein based purified diet(PD) and(ii) a common corn-soybean meal diet(CD).Plasma was collected before feeding and 0.5 h, 1 h, 2 h, 4 h, 8 h after feeding.Results: In both diets, compared to prior to feeding, the concentrations of glucose, most amino acids, metabolites such as 5-aminopentanoic acid, pipecolic acid, ornithine and 5-hydroxy-L-tryptophan were significantly increased in plasma during the first hour, whereas the concentrations of plasma triglycerides, glutamate, glycine, palmitelaidic acid, 13-HODE and oleic acid were decreased in the first hour. Compared with PD group, concentration of plasma leucine and isoleucine declined at 30 min in CD group. Plasma linoleic acid, sphingosine and many dipeptides were significantly higher in pigs fed CD.Conclusion: Most significant metabolic changes occurred during the first hour after feeding and then became relatively stable after 2 h in both diets. These results show a broad scope picture of postprandial changes in plasma metabolites after intake of PD and CD and could be a reference for further nutrition intervention as well as the design of nutritional studies. | Tiantian Li Shimeng Huang Juntao Li Hu Liu Wei Wang Na Li Meng Shi Shiyu Tao Shuai Zhang Zhen Li Junjun Wang | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 2 |
| 11 | DARPA Robotics Grand Challenge Participation and Ski-Type Gait for Rough-Terrain Walking显示文摘In this paper, we briefly introduce the history of the Defense Advanced Research Projects Agency(DARPA) Grand Challenge programs with particular focus on the 2012 Robotics Challenge. As members of team DRC-HUBO, we propose different approaches for the Rough-Terrain task, such as enlarged foot pedals and a transformation into quadruped walking. We also introduce a new gait for humanoid robot locomotion to improve stability performance, called the Ski-Type gait. We analyze the stability performance of this gait and use the stability margin to choose between two candidate step sequences, Crawl-1 and Crawl-2. Next, we perform a force/torque analysis for the redundant closedchain system in the Ski-Type gait, and determine the joint torques by minimizing the total energy consumption. Based on the stability and force/torque analysis, we design a cane length to support a feasible and stable Crawl-2 gait on the HUBO2 humanoid robot platform. Finally, we compare our experimental results with biped walking to validate the SkiType gait. We also present our team performance in the trials of the Robotics Challenge. | Hongfei Wang Shimeng Li Yuan F.Zheng | 2015 | Engineering2015，1，1： | 2 |
| 12 | Variability induced by line edge roughness in double-gate dopant-segregated Schottky MOSFETs显示文摘 | Yang Yunxiang Yu Shimeng Zeng Lang | 2011 | IEEE Transactions on Nanotechnology2011，10，2： | 1 |
| 13 | A method for improving the performance of MVDR beamforming显示文摘Minimum Variance Distortionless signal Response (MVDR) beamforming can be used as a wavenumber spectrum (bearing) estimation, whose precision or resolution is deter mined primarily by signal-to-noise ratio. This paper presents a method for improving MVDR beamforming bearing resolution by using an enhancement factor in its weight vector design for emulating a high signal-to-noise ratio condition which is known to be a principal factor in res olution improvement. This method can providc improved rcsolution not at the expense of sig nal-to noise plus interference ratio gain. Some of computer simulation results are also given. | ZHU Shimeng SONG Mingkai and GONG Xianyi (Hangzhou Applied Acoustics Research Institute. Hangzhou 311400) | 1995 | Chinese Journal of Acoustics1995，14，1： | 1 |
| 14 | The pricing of preferred hedging contingent claims under transaction costs 显示文摘 | Xu Shimeng Zhang Yu_zhong | 1998 | Applied Mathematics Journal of Chinese Universities1998，13，4： | 1 |
| 15 | Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows显示文摘Background:Zearalenone(ZEA)is a resorcylic acid lactone derivative derived from various Fusarium species that are widely found in food and feeds.The molecular structure of ZEA resembles that of the mammalian hormone 17β-oestradiol,thus zearalenone and its metabolites are known to compete with endogenous hormones for estrogen receptors binding sites and to activate transcription of oestrogen-responsive genes.However,the effect of long-term low-dose ZEA exposure on the reproductive response to Bacillus subtilis ANSB01G culture for first-parity gilts has not yet been investigated.This study was conducted to investigate the toxic effects of ZEA as an estrogen receptor selective modulator and the alleviating effects of Bacillus subtilis ANSB01G cultures as ZEA biodegraders in pregnant sows during their first parity.Results:A total of 80 first-parity gilts(Yorkshire×Landrace)were randomly assigned to four dietary treatments during gestation:CO(positive control);MO(negative control,246μg ZEA/kg diet);COA(CO+B.subtilis ANSB01G culture with 2×10^(9)CFU/kg diet);MOA(MO+B.subtilis ANSB01G culture with 2×10^(9)CFU/kg diet).There were 20 replications per treatment with one gilt per replicate.Feeding low-dose ZEA naturally contaminated diets disordered most of reproductive hormones secretion and affected estrogen receptor-αand estrogen receptor-βconcentrations in serum and specific organs and led to moderate histopathological changes of gilts,but did not cause significant detrimental effects on reproductive performance.The addition of Bacillus subtilis ANSB01G culture to the diet can effectively relieve the competence of ZEA to estrogen receptor and the disturbance of reproductive hormones secretion,and then ameliorate toxicosis of ZEA in gilts.Conclusions:Collectively,our study investigated the effects of feeding low-dose ZEA on reproduction in pregnant sows during their first parity.Feeding low-dose ZEA could modulate estrogen receptor-αand-βconcentrations in specific organs,cause disturbance of reproductive hormones and vulva swelling,and damage organ histopathology and up-regulate apoptosis in sow models.Diet with Bacillus subtilis ANSB01G alleviated negative effects of the ZEA on gilts to some extent. | Jianchuan Zhou Lihong Zhao Shimeng Huang Qingxiu Liu Xiang Ao Yuanpei Lei Cheng Ji Qiugang Ma | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 1 |
| 16 | Phosphorylation and function of DGAT1 in skeletal muscle cells显示文摘 | Jinhai Yu Yiran Li Fei Zou Shimeng Xu Pingsheng Liu | 2015 | Biophysics Reports2015，1，1： | 1 |
| 17 | Geochemistry of the extremely high thermal maturity Longmaxi shale gas,southern Sichuan Basin显示文摘 | Dai Jinxing Zou Caineng Liao Shimeng | 2014 | Organic Geochemistry2014，74，： | 1 |
| 18 | Experiment study on micro-structure on different crystallographic planes of mc-Si etched in alkaline solution显示文摘The investigation of multi-crystalline silicon(mc-Si) surface etching technology is a key point in solar cell research.In this paper,mc-Si surface was etched in the common alkaline solution modified by an additive for 20 minutes at 78-80°C.Samples' surface morphology was observed by scanning electron microscope(SEM).It is firstly found that the etched mc-Si surface has the uniform distribution of trap pits although the morphologies of trap pits are slightly different on different crystallographic planes.Si(100) plane was covered with many small Si-mountain ranges or long V-shape channels arranged in a crisscross pattern.For(110) plane and(111) plane,they were full of a lot of triangle pit-traps(or quadrilateral holes) and twisted earthworm trap pits,respectively.The measured reflectance of the sample was 20.5% at wavelength range of 400-900 nm.These results illustrate that alkaline solution modified by an additive can effectively etch out trap pits with a good trapping light effect on mc-Si surfaces.This method should be very valuable for mc-Si solar cells. | WANG KunXia FENG ShiMeng XU HuaTian TIAN JiaTong YANG ShuQuan HUANG JianHua PEI Jun | 2012 | Science China(Technological Sciences)2012，55，6： | 1 |
| 19 | Assessment of air temperatures from different meteorological reanalyses for the East Antarctic region between Zhongshan and Dome A显示文摘The accuracy of daily mean 2 meter air temperatures from five reanalyses are assessed against in-situ observations from Automatic Weather Stations in East Antarctica for 2005 to 2008.The five reanalyses all explain more than 70%of the average variance,and have annual root mean square errors(RMSE)between 3.4 and 6.9°C.The NOAA reanalyses,NCEP-1,NCEP-2and 20CRv2,have cool biases of 2.5,1.4 and 1.5°C,respectively.The ERA Interim and JCDAS reanalyses have warm biases of 1.7 and 2.0°C.All reanalyses generally perform better in the austral spring and worse in winter and autumn.They also show the best performance at an inland plateau site at 2800 m elevation,but are worst at Dome A,the summit of the East Antarctic ice sheet.In general,ERA Interim is superior to the other reanalyses,probably because of its 4D assimilation scheme.The three NOAA reanalyses perform worst;Their assimilation scheme is more constrained by limited observations and 20CRv2has less input data,assimilating only surface pressure observations.Despite deficiencies and limitations,the reanalyses are still powerful tools for climate studies in the Antarctic region.However,more in-situ observations are required,especially from the vast interior of Antarctica. | XIE AiHong Ian ALLISON XIAO CunDe WANG ShiMeng REN JiaWen QIN DaHe | 2014 | Science China Earth Sciences2014，57，7： | 1 |
| 20 | Recent progress on the hydrogen storage properties of ZrCo-based alloys applied in International Thermonuclear Experimental Reactor(ITER)显示文摘Under the development of International Thermonuclear Experimental Reactor(ITER) system aimed at realizing the controllable fusion reaction to solve the energy crisis fundamentally, there is an urgent need to find an appropriate material for tritium handling. ZrCo alloy is considered to be a promising candidate for the storage and delivery of hydrogen isotopes due to the favorable characteristics such as low plateau pressure for absorption, high dissociation pressure at moderate temperature and better ability of trapping ~3He. However, the hydrogen induced disproportionation and the slower recovery/deliverty rate of ZrCo-based alloys have limited their further application in ITER system. This review summarizes the efforts towards enhancing the hydrogen storage properties of ZrCo-based alloys including element substitution, surface modification, disproportionation mechanism investigation and the isotope effect study. Element substitution and surface modification play positive role to improve the anti-disproportionation ability and kinetic property of the alloys. However, the ZrCo-based alloys require to be further modified by more attempts such as new composition, novelty modification method or catalyst addition in order to better satisfy the application demands for tritium handling. Moreover, new insight for further understanding the inner disproportionation mechanisms of this material is needed by combining the advance characterization and theoretical analysis, which is in favor of addressing the disproportionation problem of the ZrCo-based alloys essentially. | Feng Wang Rongfeng Li Cuiping Ding Wukui Tang Yibo Wang Shimeng Xu Ronghai Yu Ying Wu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 1 |
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