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| 1 | The anti-obesity effects of EGCG in relation to oxidative stress and air-pollution in China显示文摘Modern China,similar to most developing nations,has seen a rise in the prevalence of both obesity and diesel exhaust based air pollution.The cause of obesity is multi-factorial encompassing diet,lifestyle and social factors.Also there has been a reduction in the consumption of fruit,vegetables,and traditional medicinal foods such as polyphenol containing green tea.Replacing these,are high fat and carbohydrate based processed foods which are quickly displacing these wholefoods in the diet.This review paper proposes evidence that a potential cause of obesity is also linked to environmental stress stimuli such as air pollutants,particularly diesel exhaust fumes(DEF)of>2.5μm particulate matter,and discusses a role for a green tea catechin(EGCG)for use as a dietary defence against diet and environmentally induced obesity.China is now at a critical point of a public health pandemic with rising air-borne pollution(via car exhaust fumes DEF),industry pollution such as heavy metals,and the benzene hydrocarbon based‘2PM’particulate matter,now accepted as a major environmental issue for public health.Relevant data published in MEDLINE since 1995 has been gathered to formulate the following review. | Simon CICHELLO Pingsheng LIU Markendya JOIS | 2013 | Natural Products and Bioprospecting2013，3，6： | 4 |
| 2 | Skeletal intramyocellular lipid metabolism and insulin resistance显示文摘 | Yiran Li Shimeng Xu Xuelin Zhang Zongchun Yi Simon Cichello | 2015 | Biophysics Reports2015，1，2： | 4 |
| 3 | Manuka honey: an emerging natural food with medicinal use显示文摘The health value of honey is universally acknowledged from time immemorial.Manuka(Leptospermum scoparium)is a tree,indigenous to New Zealand and South East Australia,and from the myrtle family,Myrtaceae.The honey produced from its flowers is a uni-floral honey largely produced in New Zealand.It is becoming increasingly popular as a functional food,seen in the aisles of health stores as its displays superior nutritional and phytochemistry profile over other varieties of honey.Examining existing research databases revealed its biological properties ranging from anti-oxidant,anti-inflammatory,anti-bacterial,anti-viral,anti-biotic and wound healing to immune-stimulatory properties.Methylglyoxal is the unique compound in the honey responsible for some of its potent anti-microbial properties.Further,propolis another component of honey contains chiefly flavonoids(i.e.galangin,pinocembrin),phenolic acids and their esters that may also contribute to its immuno-stimulant properties.Recent findings of the biological roles have been discussed with emphasis on the underlying mechanisms.The hurdles associated in its development as a functional food and also nutraceutical with future scopes have also been mentioned.Relevant data published in MEDLINE,Cochrane library,and EMBASE in the past decade have been gathered to formulate this review. | Seema PATEL Simon CICHELLO | 2013 | Natural Products and Bioprospecting2013，3，4： | 3 |
| 4 | 原核生物Dynamin蛋白家族的功能与进化(英文)显示文摘细胞膜系统的动态变化是原核与真核细胞中多种细胞功能实现的基础。在真核细胞中,膜的融合与分裂过程是由动力蛋白(dynamin)家族的GTP酶催化的,然而,这一机制在原核生物中却少有研究。文章总结了现有原核生物动力蛋白最新的结构和生化数据结果,探讨了它们的结构及功能特性。通过分析动力蛋白家族及其蛋白质功能域在原核生物中的进化分布,初步揭示了该蛋白家族的进化历史和功能演化,并且进一步探讨了动力蛋白参与脂滴形成和分裂过程的可能机制。基于以上研究,最后给出了动力蛋白参与脂滴动态变化的假说模型,以便于原核生物动力蛋白的功能研究。 | 耿丹丹 Simon Cichello 张少强 陈勇 | 2013 | 生物物理学报2013，29，9： | 0 |
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