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| 1 | FTY720,Sphingosine 1-Phosphate Receptor Modulator,Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibition of T Cell Infiltration显示文摘FTY720, a sphingosine 1-phosphate receptor modulator, induces a marked decrease in the number of peripheral blood lymphocytes and exerts immunomodulating activity in various experimental allograft and autoimmune disease models. In this study, we evaluated the effect of FTY720 and its active metabolite, (S)-enantiomer of FTY720-phosphate [(S)-FTY720-P] on experimental autoimmune encephalomyelitis (EAE) in rats and mice.Prophylactic administration of FTY720 at 0.1 to 1 mg/kg almost completely prevented the development of EAE,and therapeutic treatment with FTY720 significantly inhibited the progression of EAE and EAE-associated histological change in the spinal cords of LEW rats induced by immunization with myelin basic protein. Consistent with rat EAE, the development of proteolipid protein-induced EAE in SJL/J mice was almost completely prevented and infiltration of CD4+ T cells into spinal cord was decreased by prophylactic treatment with FTY720 and (S)-FTY720-P. When FTY720 or (S)-FTY720-P was given after establishment of EAE in SJL/J mice, the relapse of EAE was markedly inhibited as compared with interferon-β, and the area of demyelination and the infiltration of CD4+ T cells were decreased in spinal cords of EAE mice. Similar therapeutic effect by FTY720 was obtained in myelin oligodendrocyte glycoprotein-induced EAE in C57BL/6 mice. These results indicate that FTY720 exhibits not only a prophylactic but also a therapeutic effect on EAE in rats and mice, and that the effect of FTY720 on EAE appears to be due to a reduction of the infiltration of myelin antigen-specific CD4+ T cells into the inflammation site. | Hirotoshi Kataoka Kunio Sugaharal Kyoko Shimano Koji Teshima Mamoru Koyama Atsyshi Fukunari Kenji Chiba | 2005 | Cellular & Molecular Immunology2005，2，6： | 5 |
| 2 | Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis显示文摘AIM To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis(NASH) model influences surgical outcome.METHODS For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl_4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy(PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control. Each group was evaluated for survival rate, regeneration, apoptosis, necrosis and DNA expression after PH.RESULTS In the 70% PH of NASH group, the survival rate was significantly decreased compared with that in the control and 30% PH of NASH groups(P < 0.01). 10 of 32 mice in the NASH 70% PH group died within 48 h after PH. Serum aspartate aminotransferase(AST) levels and total bilirubin(T-Bil) in the NASH 70% PH group were significantly higher than the levels in the other two groups(AST: P < 0.05, T-Bil: P < 0.01). In both PH of NASH groups, signaling proteins involved in regeneration were expressed at lower levels than those in the control group(P < 0.01). The 70% PH of NASH group also exhibited a lower number of Ki-67-positive cells and higher rates of apoptosis and necrosis than the NASH 30% PH group(P < 0.01). In addition, DNA microarray assays showed differences in gene expression associated with cell cycle arrest and apoptosis.CONCLUSION The function of the residual liver is impaired in fatty liver compared to normal liver. A larger residual volume is required to maintain liver functions in mice with NASH. | Yusuke Ozawa Takafumi Tamura Yohei Owada Yoshio Shimizu Akira Kemmochi Katsuji Hisakura Takashi Matsuzaka Hitoshi Shimano Hiroko Isoda Nobuhiro Ohkohchi | 2018 | World Journal of Gastroenterology2018，24，15： | 2 |
| 3 | A comparison of intraoperative celiac plexus block with pharmacological therapy as a treatment for pain of unresectable pancreatic cancer显示文摘 | Masaki Okuyama Takashi Shibata Tetsushi Morita Masashi Kitada Yasuo Tukahara Yukio Fukushima Kimimasa Ikeda Junya Fuzita Takashi Shimano | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，3： | 2 |
| 4 | 显示文摘 | Shimano K Satake M Okaya A | 2003 | Am J Pathol2003，163，： | 1 |
| 5 | Differential expression of exons la and lc in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells 显示文摘 | Shimomura I Shimano H Horton J D | 1997 | Journal of clinical investigation1997，99，5： | 1 |
| 6 | Does RV lead positioning provide additional benefit to cardiac resynchronization therapy in patients with advanced heart failure? 显示文摘 | SHIMANO M INDEN Y YOSHIDA Y | 2006 | PACE2006，29，： | 1 |
| 7 | Polyunsaturated fatty acids suppress sterol regulatory elementbinding protein lc promoter activity by inhibition of liver x receptor(LXR) binding to LXR response elements显示文摘 | YOSHIKAWA T SHIMANO H YAHAGI N | 2002 | Biological Chemisry2002，277，3： | 1 |
| 8 | GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DA ergic neurons 显示文摘 | Nakajima K Hida H Shimano Y | 2001 | Brain Res2001，916，12： | 1 |
| 9 | Adiponectin promotes endothelial progenitor cell number and function显示文摘 | Rei Shibata Carsten Skurk Noriyuki Ouchi Gennaro Galasso Kazuhisa Kondo Taiki Ohashi Masayuki Shimano Shinji Kihara Toyoaki Murohara Kenneth Walsh | 2008 | FEBS Letters2008，，11： | 1 |
| 10 | Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements显示文摘 | Yoshikawa T Shimano H Yahagi N Ide T Amemiya-Kudo M Matsuzaka T Nakakuki M Tomita S Okazaki H Tamura Y Iizuka Y Ohashi K Takahashi A Sone H Osuga Ji J Gotoda T Ishibashi S Yamada N | | 0，，03： | 1 |
| 11 | Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets显示文摘 | Kato T Shimano H Yamamoto T | 2008 | Diabetes2008，57，9： | 1 |
| 12 | Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response显示文摘 | SHIMANO M OUCHI N SHIBATA R | 2010 | J Mol Cell Cardiol2010，49，： | 1 |
| 13 | Crucial role of a long- chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance显示文摘 | Matsuzaka T Shimano H Yabagi N | 2007 | Nat Med2007，13，10： | 1 |
| 14 | Effect of pilot hole on biomechanical and in vivo pedicle screw-bone interface显示文摘 | Silva P Rosa RC Shimano AC | 2013 | Eur Spine J2013，22，8： | 1 |
| 15 | Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate(SIP) is mediated by different receptor subtypes: SIP regulates the functions of murine mature dendritic cells via SlP receptor type 3 显示文摘 | Maeda Y Matsuyuki H Shimano K Kataoka H Sugahara K Chi- ba K | 2007 | J Immunol2007，178，6： | 1 |
| 16 | Oxide semiconduc- tor gas sensors 显示文摘 | Yamazoe Noboru Sakai Go Shimanoe Kengo | 2003 | Catalysis Survey Asia2003，，7： | 1 |
| 17 | Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory-element-binding protein-lc gene promoter显示文摘 | Yoshikawa T Shimano H Amemiya K M | 2001 | Mol Cell Biol2001，21，： | 1 |
| 18 | Wet processbasedfabrication of WO3 thin film for NO2 detection 显示文摘 | CHOI Y SAKAI G SHIMANOE K | 2004 | Sensors & Actuators B: Chemical2004，101，12： | 1 |
| 19 | Preparation of BiMeVOx (Me=Cu, Ti, Zr, Nb, Ta) compounds as solid electrolyte and behavior of their oxygen concentration cells 显示文摘 | Cho H S Sakai G Shimanoe K | 2005 | Sens Actuators B2005，109，2： | 1 |
| 20 | NASICON thick film-based CO2 sensor prepared by a sol-gel method 显示文摘 | KIDA T MIYACHI Y SHIMANOE K | 2001 | Sensors and Actuators B-Chemical2001，80，1： | 1 |
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