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| 1 | Optimal treatment strategies for hepatic portal venous gas:A retrospective assessment显示文摘BACKGROUND Hepatic portal venous gas(HPVG)generally indicates poor prognoses in patients with serious intestinal damage.Although surgical removal of the damaged portion is effective,some patients can recover with conservative treatments.AIM To establish an optimal treatment strategy for HPVG,we attempted to generate computed tomography(CT)-based criteria for determining surgical indication,and explored reliable prognostic factors in non-surgical cases.METHODS Thirty-four cases of HPVG(patients aged 34-99 years)were included.Necessity for surgery had been determined mainly by CT findings(i.e.free-air,embolism,lack of contrast enhancement of the intestinal wall,and intestinal pneumatosis).The clinical data,including treatment outcomes,were analyzed separately for the surgical cases and non-surgical cases.RESULTS Laparotomy was performed in eight cases(surgical cases).Seven patients(87.5%)survived but one(12.5%)died.In each case,severe intestinal damage was confirmed during surgery,and the necrotic portion,if present,was removed.Non-occlusive mesenteric ischemia was the most common cause(n=4).Twentysix cases were treated conservatively(non-surgical cases).Surgical treatments had been required for twelve but were abandoned because of the patients’poor general conditions.Surprisingly,however,three(25%)of the twelve inoperable patients survived.The remaining 14 of the 26 cases were diagnosed originally as being sufficiently cured by conservative treatments,and only one patient(7%)died.Comparative analyses of the fatal(n=10)and recovery(n=16)cases revealed that ascites,peritoneal irritation signs,and shock were significantly more frequent in the fatal cases.The mortality was 90%if two or all of these three clinical findings were detected.CONCLUSION HPVG related to intestinal necrosis requires surgery,and our CT-based criteria are probably useful to determine the surgical indication.In non-surgical cases,ascites,peritoneal irritation signs and shock were closely associated with poor prognoses,and are applicable as predictors of patients’prognoses. | Masanori Gonda Tatsuya Osuga Yoshihiro Ikura Kazunori Hasegawa Kentaro Kawasaki Takatoshi Nakashima | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 2 | Study on steel plate reinforced concrete panels subjected to cyclic in-plane shear显示文摘 | Masahiko Ozaki Shodo Akita Hiroshi Osuga Tatsuo Nakayama Naoyuki Adachi | 2003 | Nuclear Engineering and Design2003，，1： | 3 |
| 3 | Increased risk of placenta previa is associated with endometriosis and tubal factor infertility in assisted reproductive technology pregnancy显示文摘 | Yuri Takemura Yutaka Osuga Akihisa Fujimoto Nagisa Oi Ryo Tsutsumi Minako Koizumi Tetsu Yano Yuji Taketani | 2013 | Gynecological Endocrinology2013，，2： | 2 |
| 4 | Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis 显示文摘 | Sata M Nishimatsu H Osuga J | 2004 | Hypertension2004，43，： | 1 |
| 5 | Molecular analysis of a novel LCAT mutation (Gly179--~Arg) found in a patient with a complete LCAT deficiency显示文摘 | Wang XL Osuga J Tazoe F | 2011 | J Atheroscler Thromb2011，18，8： | 1 |
| 6 | GnRH II as a possible cytostatic regulator in the development of endometriosis显示文摘 | Morimoto C Osuga Y Yano T | 2005 | Hum Reprod2005，20，： | 1 |
| 7 | Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from IL-1β,TNF-α,and IL-17A stimulated endometriotic stromal cells显示文摘 | Hirata T Osuga Y Takamura M | 2010 | Endocrinology2010，151，11： | 1 |
| 8 | Expression of adiponectin receptors and its possible implication in the human endometrium显示文摘 | Takemura Y Osuga Y Yamauchi T | 2006 | Endocrinology2006，147，7： | 1 |
| 9 | Regulation of nitric oxide synthase to promote cytostasis in ovarian follicular development显示文摘 | Yano T Osuga Y | 2000 | Biol Reprod 2000(7)2000，63，1： | 1 |
| 10 | Cyclic stretch augments pro- duction of neutrophil chemokines and matrix metalloproteinase- 1 in human uterine smooth muscle cells显示文摘 | Zhao Y Koga K Osuga Y | | Am J Reprod Im- munol0，69，： | 1 |
| 11 | Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements显示文摘 | Yoshikawa T Shimano H Yahagi N Ide T Amemiya-Kudo M Matsuzaka T Nakakuki M Tomita S Okazaki H Tamura Y Iizuka Y Ohashi K Takahashi A Sone H Osuga Ji J Gotoda T Ishibashi S Yamada N | | 0，，03： | 1 |
| 12 | Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia显示文摘 | Koga K Osuga Y Yoshino O | 2003 | J Clin Endocrinol Metab2003，88，5： | 1 |
| 13 | Cyclin-depedent Kinases as a Therapeutic Target for Stroke显示文摘 | OSUGA H OSUGA S WANG FH | 2000 | Proc Natl Acad Sci USA (S0027 - 8424)2000，97，10： | 1 |
| 14 | Usefulness of epidural anaesthesia in gynecologic laparoscopic surgery for infertility in comparision to general anesthesia显示文摘 | Karamochi K Osuga Y Yano T | 2004 | Surg Endose2004，18，5： | 1 |
| 15 | Cellular mechanisms of growth inhibition of human epithelia ovarian cancer cell line by LH releasing hormone antagonist ce trorelix显示文摘 | Tang X Yano T Osuga Y Matsumi H Yano N Xu J el al | 2002 | J Ciin Endocrinol Metab2002，87，： | 1 |
| 16 | Interleukin-lb stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSEP in endometriosis显示文摘 | Yoko Urata Yutaka Osuga Gentaro Izumi | 2012 | Hum Reprod2012，27，10： | 1 |
| 17 | Molecular pathogenesis of hepatoli- thiasis--a type of low phospholipid-associated chnlelithiasis 显示文摘 | Shoda J Inada Y Osuga T | 2006 | Front Biosci2006，11，： | 1 |
| 18 | Cellular mechanisms of growth inhibition of human epithelial ovarian cancer cell line by LH-releasfing hormone antagonist cetrorelix显示文摘 | Tang X Yano T Osuga Y | 2002 | J Clin End-ocrinol Metab2002，87，8： | 1 |
| 19 | Recurrence of ovarian endom-etrioma after laparoscopic excision显示文摘 | Koga K Takemura Y Osuga Y | 2006 | Hum Reprod2006，21，8： | 1 |
| 20 | Elevated serum soluble vascular endothelial growth factor receptor 1(sVEGFR-1) levels in women with preeclampsia显示文摘 | Koga K Osuga Y Yoshino O | 2003 | J Clin Endocrinol Metab2003，88，5： | 1 |
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