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		题名	作者	年代	出处	被引量
	1	Role of vitamin B_(12) on methylmalonyl-CoA mutase activity显示文摘Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their cofactors.Among them,methylmalonyl-CoA mutase (MCM) has been extensively studied.This enzyme catalyzes the reversible isomerization of L-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor participating in the generation of radicals that allow isomerization of the substrate.The crystal structure of MCM determined in Propionibacterium freudenreichii var.shermanii has helped to elucidate the role of this cofactor AdoCbl in the reaction to specify the mechanism by which radicals are generated from the coenzyme and to clarify the interactions between the enzyme,coenzyme,and substrate.The existence of human methylmalonic acidemia (MMA) due to the presence of mutations in MCM shows the importance of its role in metabolism.The recent crystallization of the human MCM has shown that despite being similar to the bacterial protein,there are significant differences in the structural organization of the two proteins.Recent studies have identified the involvement of an accessory protein called MMAA,which interacts with MCM to prevent MCM's inactivation or acts as a chaperone to promote regeneration of inactivated enzyme.The interdisciplinary studies using this protein as a model in different organisms have helped to elucidate the mechanism of action of this isomerase,the impact of mutations at a functional level and their repercussion in the development and progression of MMA in humans.It is still necessary to study the mechanisms involved in more detail using new methods.	Tóshiko TAKAHASHI-IIGUEZ Enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA María Elena FLORES	2012	Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，6：	3
	2	Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘	Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori	2004	Journal of Gastroenterology2004，，9：	2
	3	Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘	Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori	2004	Journal of Gastroenterology2004，，9：	1
	4	A Prospective Randomized Controlled Trial of AJG522 versus Standard PEG + E as Bowel Preparation for Colonoscopy显示文摘	Toshihiko Sagawa Ken Sato Taku Tomizawa Masafumi Mizuide Hidetoshi Yasuoka Yasuyuki Shimoyama Shiko Kuribayashi Satoru Kakizaki Osamu Kawamura Motoyasu Kusano Masanobu Yamada Sachiyo Nomura	2015	BioMed Research International2015，，：	1
	5	No ghrelin response to oral glucose in diabetes mellitus with gastroparesis 显示文摘	Shiko A Takuyuki K Naoko O	2009	Endo crine J2009，56，1：	1
	6	Determination of tel- lurium in coal samples by means of graphite furnace atomic absorption spectrometry after coprecipitation with ironed hydroxide显示文摘	Sachi Oda Yo Shiko Arikawa	2005	Bunseki Kagaku (The Ja- pan Society for Analytical Chemistry)2005，54，11：	1
	7	Nondestructive acoustic impulse response method for measuring internal quality of apples and watermelons显示文摘	Hiromichi Yamamoto Mutsuo Iwamoto Shiko Haginuma	1981	Journal of Japan Society Hort Science1981，50，20：	1
	8	NMR and gas sorption studies of structure-transport relationships in porous media显示文摘	Shiko Elenica	2013	University of Bath2013，，：	1
	9	Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘	Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori	2004	Journal of Gastroenterology2004，，9：	1
	10	Duct - to - duct biliary reconstruction in living donor liver transplantation utilizing right lobe graft 显示文摘	SHIKO T EGAWA H KASAHARA M	2002	Ann Surg2002，236，2：	1
	11	Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘	Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori	2004	Journal of Gastroenterology2004，，9：	1

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