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| 1 | Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis显示文摘AIM: To evaluate the effi cacy of continuous regional arterial infusion therapy (CRAI) with gabexate mesilate and antibiotics for severe acute pancreatitis (SAP). METHODS: We conducted a prospective study on patients who developed SAP with or without CRAI. Out of 18 patients fulf illed clinical diagnostic criteria for SAP in Japan, 9 patients underwent CRAI, while 9 patients underwent conventional systemic protease inhibitor and antibiotics therapy (non-CRAI). CRAI was initiated within 72 h of the onset of pancreatitis. Gabexate mesilate (2400 mg/d) was continuously administered for 3 to 5 d. The clinical outcome including serum infl ammation-related parameters were examined. RESULTS: The duration of abdominal pain in the CRAI group was 1.9 ± 0.26 d, whereas that in the non-CRAI group was 4.3 ± 0.50. The duration of SIRS in the CRAI group was 2.2 ± 0.22 d, whereas that in the non- CRAI group was 3.2 ± 0.28. Abdominal pain and SIRS disappeared signifi cantly in a short period of time after the initiation of CRAI using gabexate mesilate. The average length of hospitalization signifi cantly differed between the CRAI and non-CRAI groups, 53.3 ± 7.9 d and 87.4 ± 13.9 d, respectively. During the first two weeks, levels of serum CRP and the IL6/IL10 ratio in the CRAI group tended to have a rapid decrease compared to those in the non-CRAI group. CONCLUSION: The present results suggest that CRAI using gabexate mesilate was effective against SAP. | Yoshifumi Ino Yoshiyuki Arita Tetsuro Akashi Toshinari Kimura Hisato Igarashi Takamasa Oono Masayuki Furukawa Ken Kawabe Keiichiro Ogoshi Jiro Ouchi Toshihiko Miyahara Ryoichi Takayanagi Tetsuhide Ito | 2008 | World Journal of Gastroenterology2008，14，41： | 20 |
| 2 | Applications of finite element simulation in orthopedic and trauma surgery显示文摘Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography(CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element(FE) simulation lets us know the biomechanical changes that take place after hipprostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints applied to the correction of deformities, providing the recovering force-displacement and angle-moment curves that characterize the mechanical behavior of the splint in the overall range of movement. | Antonio Herrera Elena Ibarz José Cego?ino Antonio Lobo-Escolar Sergio Puértolas Enrique López Jesús Mateo Luis Gracia | 2012 | World Journal of Orthopedics2012，3，4： | 8 |
| 3 | Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘 | Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori | 2004 | Journal of Gastroenterology2004，，9： | 2 |
| 4 | Effects of Brain-Derived Neurotrophic Factor (BDNF) on Compression-Induced Spinal Cord Injury: BDNF Attenuates Down-Regulation of Superoxide Dismutase Expression and Promotes Up-Regulation of Myelin Basic Protein Expression显示文摘 | OSAMU IKEDA MASAZUMI MURAKAMI HIDETOSHI INO MASASHI YAMAZAKI MASAO KODA CHIKAO NAKAYAMA HIDESHIGE MORIYA | 2002 | JNEN: Journal of Neuropathology & Experimental Neurology2002，，2： | 2 |
| 5 | Functional expression of the angiotensin Ⅱ type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, an-giogenesis, and peritoneal dissemination 显示文摘 | Suganuma T Ino K Shibata K | 2005 | Clin Cancer Res2005，11，7： | 1 |
| 6 | Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion显示文摘 | Coll the PPAR ino M Aragno M Ma oxidative stress -gamma agonists in stro and the cola R et a7 | 2006 | Eur J Pharmacol2006，530，： | 1 |
| 7 | Natural history and prognostic risk factors in endocardial fibroelastosis显示文摘 | INO T BENDOM L N FREDOMR M | 1988 | Am J Cardiol1988，62，： | 1 |
| 8 | Extraction of rhodium from other platinum group metals with Kelex 100 from chloride media containing tin显示文摘 | Alam M S Inoe K | 1997 | Hydrometallurgy1997，46，3： | 1 |
| 9 | Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model显示文摘 | YOSHIDA N INO K ISHIDA Y | 2008 | Clin Cancer Res2008，14，22： | 1 |
| 10 | Optical coherence tomography imaging in acute coronary syndromes显示文摘 | Kubo T Ino Y Akasaka T | | 0，，： | 1 |
| 11 | The influence of diseases on Lotka- Volterra system显示文摘 | VENTUR INO E | 1994 | Rlckymount J Math1994，24，1： | 1 |
| 12 | Expression of interleukin-10 in isolated CD8 +T cell and monocytes from growth factor-mobilized peripheral blood stem cell products: a mechanism of immune dysfunction 显示文摘 | Ino K Ageitos AG | 1999 | J Interferon Cytokine Res1999，19，4： | 1 |
| 13 | Survival rates of patients with choriocarcinoma treated with chemotherapy without hysterectomy: effects of anticancer agents on subsequent births显示文摘 | Setsuko Goto Kazuhiko Ino Takashi Mitsui Fumitaka Kikkawa Takanobu Suzuki Seiji Nomura Shigehiko Mizutani | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 14 | Triple combination of oncolytic herpes simplex virus-1 vectors armed with interleukin-12,interleukin-18,or soluble B7-1 results in enhanced antitumor efficacy显示文摘 | Ino Y Saeki Y Fukuhara H | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 15 | Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to e-cadherin expression 显示文摘 | Shimamura T Sakamoto M Ino Y | 2003 | J Clin Oncol2003，21，4： | 1 |
| 16 | Improved use of arterial 1 blood gasAnalysis in suspected plume nary embolism 显示文摘 | Cvitanic O Mar ino PL | 1989 | Chest1989，95，： | 1 |
| 17 | E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma显示文摘 | Osada T Sakamoto M Ino Y | | Hepatology0，，： | 1 |
| 18 | Human keratinocytes that express bTERT and also bypass a p16INK4a-enforced mechanism that limits life span become immortal yet retain normal gowth and differentiation characteristics 显示文摘 | DICKSON M A HAHN W C INO Y | 2000 | Mol Cell Biol2000，20，： | 1 |
| 19 | Dysadherin : expression and clinical significance in thyroid carcinoma 显示文摘 | Sato H Ino Y Miura A | 2003 | J Clin Endocrinol Metab2003，88，9： | 1 |
| 20 | Assessment of QT intervals and prevalence of short QT syndrome in Japan显示文摘 | Funada A Hayashi K Ino H | 2008 | Clin Cardiol2008，31，： | 1 |
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