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12篇 您的检索式：作者名="Sherven"

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		题名	作者	年代	出处	被引量
	1	Targeting BMI-1-mediated epitheliale-mesenchymal transition to inhibit colorectal cancer liver metastasis显示文摘Liver is the most common metastatic site for colorectal cancer(CRC),there is no satisfied approach to treat CRC liver metastasis(CRCLM).Here,we investigated the role of a polycomb protein BMI-1 in CRCLM.Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage,invasion depth and right-sided primary tumor.Knockdown BMI-1 in high metastatic HCT116 and LOVO cells repressed the migratory/invasive phenotype and reversed epithelialemesenchymal transition(EMT),while BMI-1 overexpression in low metastatic Ls174 T and DLD1 cells enhanced invasiveness and EMT.The effects of BMI-1 in CRC cells were related to upregulating snail via AKT/GSK-3βpathway.Furthermore,knockdown BMI-1 in HCT116 and LOVO cells reduced CRCLM using experimental liver metastasis mice model.Meanwhile,BMI-1 overexpression in Ls174 T and DLD1 significantly increased CRCLM.Moreover,sodium butyrate,a histone deacetylase and BMI-1 inhibitor,reduced HCT116 and LOVO liver metastasis in immunodeficient mice.Our results suggest that BMI-1 is a major regulator of CRCLM and provide a potent molecular target for CRCLM treatment.	Zhiyao Xu Zhuha Zhou Jing Zhang Feichao Xuan Mengjing Fan Difan Zhou Zhenyu Liuyang Ximei Ma Yiyang Hong Yihong Wang Sherven Sharma Qinghua Dong Guanyu Wang	2021	Acta Pharmaceutica Sinica B2021，11，5：	8
	2	Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer显示文摘	Kostyantyn K Harnisha D Sherven S	2004	Cancer Res2004，64，18：	1
	3	HDAC inhibitors reverse ac-quired radio resistance of KYSE-150R esophageal carcinoma cellsby modulating Bmi-1 expression显示文摘	Dong QH Sherven S Liu H	2013	Toxicol Lett2013，224，1：	1
	4	Indomethacin-Enhanced Anticancer Effect of Arsenic Trioxide in A549 Cell Line: Involvement of Apoptosis and Phospho-ERK and p38 MAPK Pathways显示文摘	Ali Mandegary Maryam Torshabi Mohammad Seyedabadi Bagher Amirheidari Elham Sharif Mohammad Hossein Ghahremani Sherven Sharma	2013	BioMed Research International2013，，：	1
	5	Cyclooxygenase-2 dependent expression of survivin is critical for apeptosis resistance in non-small cell lung cancer显示文摘	Kostyantyn K Hamisha D Sherven S	2004	Cancer Research2004，64，18：	1
	6	Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells 显示文摘	Ling Zhang Sherven S Li X	2003	Cancer Research2003，，：	1
	7	Secondary lymphoid tissue chemokine mediates T cell-dependant antitumor responses in vivo显示文摘	Sherven S Marina S Jie L	2000	J Immunol2000，164，9：	1
	8	Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma显示文摘	Marina Stolina Li Zhu	2001	Cancer Research2001，61，17：	1
	9	Specific inhibition of cyclooxygenase-2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis显示文摘	Marina S Sherven S Ying L	2000	J Immunol2000，164，2：	1
	10	MUC1 peptide vaccine mediated antitumor activity in non-small cell lung cancer 显示文摘	Sherven Sharma Minu K Srivastava Marni Harris White	2011	Expert Opinion on Biological Therapy2011，11，8：	1
	11	The Utility of Digital Linear Tomosynthesis Imaging of Total Hip Joint Arthroplasty with Suspicion of Loosening: A Prospective Study in 40 Patients显示文摘	Jan H. G?thlin Mats Geijer Sherven Sharma	2013	BioMed Research International2013，，：	1
	12	The role of miRNA in inflammation and autoimmunity显示文摘	Ram Pyare Singh Israel Massachi Sudhir Manickavel Satendra Singh Nagesh P. Rao Sascha Hasan Deborah K. Mc Curdy Sherven Sharma David Wong Bevra H. Hahn Hamida Rehimi	2013	Autoimmunity Reviews2013，，：	1

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