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| 1 | Iron and liver fibrosis: Mechanistic and clinical aspects显示文摘Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis. | Kosha J Mehta Sebastien Je Farnaud Paul A Sharp | 2019 | World Journal of Gastroenterology2019，25，5： | 39 |
| 2 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 3 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 4 | Prognostic value of baseline FDG uptake on PET-CT in esophageal carcinoma显示文摘AIM: To evaluate the influence of baseline maximum standardized uptake value(SUVmax) on survival in a cohort of patients, undergoing positron emission tomography-computed tomography(PET-CT) scan for esophageal carcinoma. METHODS: The pre-treatment SUVmax numeric reading was determined in patients with confirmed esophageal or junctional cancer having PET-CT scan during the time period 1st January 2007 until 31 st July 2012. A minimum follow up of 12 mo was required. Patients were subdivided into quartiles according to SUVmax value and the influence of SUVmax on survival was assessed using univariate and multivariate analysis. The following pre-treatment factors were investigated: patient characteristics, tumor characteristics and planned treatment. RESULTS: The study population was 271 patients(191male) with esophageal or junctional carcinoma. The median age was 65 years(range 40-85) and histologic subtype was adenocarcinoma in 197 patients and squamous carcinoma in 74 patients. The treatment intent was radical in 182 and palliative in 89 patients. SUVmax was linked to histologic subtype(P = 0.008), tumor site(P = 0.01) and Union for International Cancer Control(UICC) stage(P < 0.001). On univariate analysis, prognosis was significantly associated with SUVmax(P = 0.001), T-stage(P < 0.001) and UICC stage(P < 0.001). On multivariate analysis, only T-stage and UICC stage remained significant. CONCLUSION: Pretreatment SUVmax was not a useful marker in isolation for determining prognosis of patients with esophageal carcinoma. | Omar S Al-Taan Amar Eltweri David Sharpe Peter M Rodgers Sukhbir S Ubhi David J Bowrey | 2014 | World Journal of Gastrointestinal Oncology2014，6，5： | 2 |
| 5 | Response phase of the flicker electroretinogram (ERG) is influenced by cone excitation strength显示文摘 | Usui T Kremers J Sharpe LT | 1998 | Vision Res1998，38，： | 2 |
| 6 | Cholesterol and blood pressure loeing effects of immune milk显示文摘 | SARP S J GAMBLE G D SHARP D N | 1994 | Am J Clin Nutr1994，59，： | 2 |
| 7 | Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review显示文摘 | Sharp L Little J | 2004 | Am J Epidemiology2004，159，5： | 1 |
| 8 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 9 | The B7 family revisited 显示文摘 | Greenwald R J Freeman GJ Sharpe AH | 2005 | Annu Rev Immunol2005，23，： | 1 |
| 10 | Fracture strength of polysilicon atstress concentrations显示文摘 | Bagdahn J Sharpe W N Jadaan O | 2003 | Journal of Micro- electromechanical Systems2003，12，3： | 1 |
| 11 | Control of mitochondrial permeability by Bcl-2 family members显示文摘 | SHARPE J C AMOULTT D YOULE R J | 2004 | Biochim Biophys Acta2004，1644，23： | 1 |
| 12 | Production of hydrogen from chemical hydrides via hydrolysis with steam 显示文摘 | AIELLO R SHARP J H MATTHEWS M A | 1999 | International Journal of Hydrogen Energy1999，24，12： | 1 |
| 13 | The production of elastic waves by explosion pressures: Ⅰ, Theory and empirical observations显示文摘 | Sharpe J A | 1942 | Geophysics1942，7，： | 1 |
| 14 | Non-gridded library: a new approach for BAC (bacterial artificial chromosome) exploitation in hexaploid wheat (Triticum aestivum)显示文摘 | MA ZHIYING SONG WEINING PETER J SHARP | 2000 | Nucleic Acids Research2000，28，24： | 1 |
| 15 | The dissolved organic carbon controversy:An update显示文摘 | Sharp J | 1993 | Oceanography1993，，6： | 1 |
| 16 | Case study:a state space condition monitoring model for furnace erosion prediction and replacement显示文摘 | Christer A H Wang W Sharp J M | 1997 | European Journal of Operational Research1997，101，1： | 1 |
| 17 | Microbial life beneath a High Arctic glacier显示文摘 | Skidmore M L Foght J M Sharp M J | 2000 | Applied and Environmental Microbiology2000，66，8： | 1 |
| 18 | Lack of relationship between concentrations of plasma luteinizing hormone, thyroxine, and prolactin at nine weeks of age and subsequent egg production in the domestic hen显示文摘 | Sharp P J Van Tijen W F Middelkoop J H | 1981 | Br Pouh Sci1981，22，： | 1 |
| 19 | The function of programmed cell death I and its ligands in regulating autoimmunity and infection显示文摘 | Sharpe AH Wherry E J Ahmed R | 2007 | Nat Immunol2007，8，3： | 1 |
| 20 | Chicken leptin 显示文摘 | Sharp P J Dunn I C Waddington D | 2008 | Gen Comp Endocrinol2008，1，1： | 1 |
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