|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity显示文摘We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimetics to block the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 histone methyltransferase activity.Our study has yielded cyclic peptidomimetics with very high binding affinities to WDR5(Kivalues <1 nmol/L) and function as antagonists of the MLL1 histone methyltransferase activity. | Hacer Karatas Shirley Y.Lee Elizabeth C.Townsend Fang Cao Jing Xu Denzil Bernard Liu Liu Yali Dou Shaomeng Wang | 2015 | Chinese Chemical Letters2015，26，4： | 3 |
| 2 | Characterizations of cis-pinonic acid and n-fatty acids on fine aerosols in the Lower Fraser Valley during Pacific 2001 air quality study 显示文摘 | CHENG Yu LI Shaomeng LEITHEAD A | 2004 | Atmos Environ2004，38，34： | 1 |
| 3 | Study on the radial sheet beam electron optical system显示文摘 | Wang Shaomeng Gong Yubin Wei Yanyu | 2012 | IEEE Trans on Plasma Sci- ence2012，40，12： | 1 |
| 4 | Preclinicalstudies of a nonpeptidic small-moleculeinhibitor of Bcl-2 and Bcl-XL against diffuse large cell lymphoma显示文摘 | MOHAMMAD R M WANG Shaomeng ABOUKAMEEL A | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 5 | The Pacific 2001 air quality study: synthesis of findings and policy implications 显示文摘 | Roxanne V Li Shaomeng | 2006 | Atmospheric Environment2006，40，： | 1 |
| 6 | Design of a novel chimeric peptide via dual blockade of CD47/SIRPαand PD-1/PD-L1 for cancer immunotherapy显示文摘Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types,only a small subset of patients can benefit from PD-1/PD-L1 blockade.CD47 expressed on tumor cells protects them from phagocytosis through interaction with SIRPαon macrophages,while PD-L1 dampens T cell-mediated tumor killing.Therefore,dual targeting PD-L1 and CD47 may improve the efficacy of cancer immunotherapy.A chimeric peptide Pal-DMPOP was designed by conjugating the double mutation of CD47/SIRPαblocking peptide(DMP)with the truncation of PD-1/PD-L1 blocking peptide OPBP-1(8-12)and was modified by a palmitic acid tail.Pal-DMPOP can significantly enhance macrophage-mediated phagocytosis of tumor cells and activate primary T cells to secret IFN-γin vitro.Due to its superior hydrolysis-resistant activity as well as tumor tissue and lymph node targeting properties,Pal-DMPOP elicited stronger anti-tumor potency than Pal-DMP or OPBP-1(8-12)in immune-competent MC38 tumor-bearing mice.The in vivo anti-tumor activity was further validated in the colorectal CT26 tumor model.Furthermore,Pal-DMPOP mobilized macrophage and T-cell anti-tumor responses with minimal toxicity.Overall,the first bispecific CD47/SIRPαand PD-1/PD-L1 dual-blockade chimeric peptide was designed and exhibited synergistic anti-tumor efficacy via CD8^(+)T cell activation and macrophage-mediated immune response.The strategy could pave the way for designing effective therapeutic agents for cancer immunotherapy. | Zheng Hu Wanqiong Li Shaomeng Chen Danhong Chen Ran Xu Danlu Zheng Xin Yang Shuzhen Li Xiuman Zhou Xiaoshuang Niu Youmei Xiao Zhuoying He Huihao Li Juan Liu Xinghua Sui Yanfeng Gao | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 7 | A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells显示文摘 | Hui Song Renxiao Wang Shaomeng Wang | 2005 | PNAS2005，102，13： | 1 |
| 8 | Occurrence of polybrominated diphenyl ethers in air and precipitation of the Pearl River Deha, South China: annual washout ratios and depositional rates显示文摘 | ZHANG Baozhong GUAN Yufeng LI Shaomeng | 2009 | Environ Sci Technol2009，43，24： | 1 |
| 9 | THz trapped ion model and THz spectroscopy detection of potassium channels显示文摘Advanced molecular dynamics(MD)simulation and infrared(IR)spectroscopy have been widely adopted to reveal the detailed dynamic process of high-speed selective permeability of potassium channels.Yet these MD simulations cannot avoid the choice of empirical molecular force fields and high transmembrane voltages(as driving electric fields for ions)far exceeding physiological levels.Moreover,the IR spectroscopy method usually requires isotope labels for carbonyl groups of the channels,which may change the original permeation process.Here,we build the terahertz(THz)trapped ion model for the selectivity filter(SF)of potassium channels KcsA based on the density functional theory(DFT)calculation of ion potentials.In this model,the zero-point energy of trapped ions and quantum tunneling effect provide the physical basis for near diffusion limited permeation rates of ions and explain the high driving electric field in MD simulations.Quantitative calculations of zero-point energy and tunneling probability show that the quantum effect assisted knock-on mechanism may help to realize the physiological functions of potassium channels.Furthermore,based on the trapped ion model,we calculated the ion decoherence timescale under the influence of protein environmental noise.We use the quantum optics method to describe the interaction between THz waves and the trapped ion.Then the novel THz spectroscopy approaches through the THz resonance fluorescence and the intense field non-resonant effect are presented theoretically.These are expected to be isotope label-free detective methods of the rapid ion permeation dynamics. | Kaicheng Wang Shaomeng Wang Lixia Yang Zhe Wu Baoqing Zeng Yubin Gong | 2022 | Nano Research2022，15，4： | 1 |
| 10 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 11 | Competitive and Reversible Binding of a Guest Molecule to Its Host in Aqueous Solution through Molecular Dynamics Simulatio: Benzyl Alcohol/b-Cyclodextrin System显示文摘 | Varady Judith Wu Xiongwu Wang Shaomeng | 2002 | J Phys Chem B2002，106，： | 1 |
| 12 | Comparative inactivation of enteric adenoviruses, poliovirus and coliphages by ultraviolet irradiation显示文摘 | Qin Shaomeng Charles P Gerba | 1996 | Wat Res1996，30，11： | 1 |
| 13 | Discovery of a Novel Dopamine Tansporter Inhibitor Through a 3D-Database Pharmacophore Searching显示文摘 | | 2000 | J Med Chem2000，43，： | 1 |
| 14 | Research on thermal risk and decomposition behavior of methyl nitrite显示文摘The thermal hazards of methyl nitrite(MN)were investigated in the present study.The determination and evaluation of MN decomposition were conducted using a C600 micro thermometer.The thermal runaway reaction characteristics of the compound under different initial pressures were obtained using a VSP2 calorimeter.The kinetic parameters of MN were obtained by regression fitting and calculation of the microthermal experimental data.The experimental and calculated results demonstrated that the potential explosion risk of MN is very high.In addition,there was a high energy barrier in the early stage of the uncontrolled decomposition of MN;however,once the decomposition reaction was initiated,the subsequent decomposition was easily conducted.Under the conditions of adiabatic simulation,the possibility that the reaction was uncontrolled increases with the initial temperature and pressure of the system,and there is a great potential safety risk. | Haoyu Zhai Shaomeng Wang Diankun Chen Xuanying Cheng Chuanxin Xie | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 1 |
| 15 | Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2and Bcl-XL against diffuse large cell lymphoma显示文摘 | MOHAMMAD R M WANG Shaomeng ABOUKAMEEL A | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 16 | An integrated machine learning model for accurate and robust prediction of superconducting critical temperature显示文摘Discovering new superconductors via traditional trial-and-error experimental approaches is apparently a time-consuming process,and the correlations between the critical temperature(Tc) and material features are still obscure.The rise of machine learning(ML) technology provides new opportunities to speed up inefficient exploration processes,and could potentially uncover new hints on the unclear correlations.In this work,we utilize open-source materials data,ML models,and data mining methods to explore the correlation between the chemical features and Tcvalues of superconducting materials.To further improve the prediction accuracy,a new model is created by integrating three basic algorithms,showing an enhanced accuracy with the coefficient of determination(R2) score of 95.9 % and root mean square error(RMSE) of 6.3 K.The average marginal contributions of material features towards Tcvalues are estimated to determine the importance of various features during prediction processes.The results suggest that the range thermal conductivity plays a critical role in Tcprediction among all element features.Furthermore,the integrated ML model is utilized to screen out potential twenty superconducting materials with Tcvalues beyond 50.0 K.This study provides insights towards Tcprediction to accelerate the exploration of potential high-Tcsuperconductors. | Jingzi Zhang Ke Zhang Shaomeng Xu Yi Li Chengquan Zhong Mengkun Zhao Hua-Jun Qiu Mingyang Qin X.-D.Xiang Kailong Hu Xi Lin | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 17 | Research on Landscape Planning and Design of Education Practice Base——A Case Study of Shengquan Education Practice Base in Feidong County of Hefei City of China显示文摘By taking landscape planning and design of Shengquan Educational Practice Base in Feidong County of Hefei City for example, the paper has analyzed its base condition, planning target of the construction of 'the thought tank of Chinese culture', and landscape construction distinguished from modern and traditional agricultural sightseeing park. It has identified its position, and highlighted the combination of education and practice. Then, in the perspective of 'one axis, two belts and four areas', its general layout has been illustrated, and the specific practice contents and plant landscape construction in the practice park and activity route have been introduced in detail. It has emphasized its characteristic dominant projects and established its brand, so as to achieve the win-win of education practice significance and economic benefit. | QIN Jian ZHANG Fei SUN Shaomeng | 2012 | Journal of Landscape Research2012，4，8： | 0 |
| 18 | 20736-node weighted max-cut problem solving by quadrature photonic spatial Ising machine显示文摘The max-cut problem is one of the fundamental NP-hard problems in combinatorial optimization,which can describe the practical applications such as data clustering,machine scheduling,and image recognition.This problem can be formulated into an equivalent Ising model without local fields. | Xin YE Wenjia ZHANG Shaomeng WANG Xiaoxuan YANG Zuyuan HE | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 19 | Effect of Co on the martensitic transformation,crystal structure and magnetization of Ni_(52.5) Mn_(23.5) Ga_(24) based ferromagnetic shape memory alloys显示文摘Five(Ni52.5Mn23.5Ga24)100-xCox(x = 0,2,4,6,8) alloys were prepared by arc melting,and the effects of Co addition on the martensitic phase transformation,crystal structure and magnetization were investigated.The phase transformation temperatures Ms,Mf,As and Af are proportional to the content of Co in the(Ni52.5Mn23.5Ga24)100-xCox alloys,which appears to be due to the variation in the valance electron concentration.The Curie temperature is sensitive to the composition of the alloy.As the amount of Co changes,both the Co-Mn exchange interaction and the distance between Mn atoms change.These,in turn,affect the Curie temperature and magnetization behavior of the alloy.The martensite phases in all the alloys are domained in three different orientations,the domain boundary was determined to belong to the family of {112} lattice planes. | YAN ShaoMeng PU Jian CHI Bo LI Jian | 2011 | Chinese Science Bulletin2011，56，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员