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| 1 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 2 | Hydroisomerization performance of platinum supported on ZSM-22/ZSM-23 intergrowth zeolite catalyst显示文摘Hydroisomerization catalysts Pt/ZSM-22,Pt/ZSM-23,and Pt/ZSM-22/ZSM-23 were prepared by supporting Pt on ZSM-22,ZSM-23,and intergrowth zeolite ZSM-22/ZSM-23,respectively.The typical physicochemical properties of these catalysts were characterized by X-Ray Diffraction(XRD),N2 absorption-desorption,Pyridine-Fourier Transform Infrared(Py-FTIR),Transmission Electron Microscopy(TEM),X-Ray Fluorescence(XRF),Scanning Electron Microscopy(SEM) and NH3-Temperature Programmed Desorption(NH3-TPD),and the performance of these catalysts in n-dodecane hydroisomerization was evaluated in a continuous down-flow fixed bed with a stainless steel tubular reactor.The characterization results indicated that the intergrowth zeolite ZSM-22/ZSM-23 possessed the dual structure of ZSM-22 and ZSM-23,and the catalyst Pt/ZSM-22/ZSM-23 had similar pores and weak acidity to Pt/ZSM-22 and Pt/ZSM-23 catalysts.Moreover,Pt/ZSM-22/ZSM-23 catalyst showed a high selectivity in hydroisomerization of long chain n-alkanes to mono-branched isomers.The evaluation results for n-dodecane hydroisomerization indicated that the activity of Pt/ZSM-22/ZSM-23 was the lowest,while the hydroisomerization selectivity was the highest among the three catalysts.The maximum yield of i-dodecane product was 68.3% over Pt/ZSM-22/ZSM-23 at 320 oC. | Chi Kebin Zhao Zhen Tian Zhijian Hu Sheng Yan Lijun Li Tianshu Wang Bingchun Meng Xiangbin Gao Shanbin Tan Mingwei Liu Yanfeng | 2013 | Petroleum Science2013，10，2： | 8 |
| 3 | H_2 /H_∞ control of networked control system with random time delays显示文摘This paper investigates the H 2 /H ∞ control problem for a class of discrete-time networked control systems with random communication time delays. Both sensor-to-controller (S-C) and controller-to-actuator (C-A) random network-induced delays are considered. Two independent Markov chains are used to model the S-C and C-A random delays. The resulting closed-loop system is a jump linear time-delay system induced by two Markov chains. Sufficient conditions for existence of H 2 /H ∞ controller are established by free-weighting matrix and stochastic Lyapunov functions. A simulation example illustrates the effectiveness of the proposed method. | QIU Li XU BuGong LI ShanBin | 2011 | Science China(Information Sciences)2011，54，12： | 5 |
| 4 | Using scores of amino acid topological descriptors for quantitative sequence-mobility modeling of peptides based on support vector machine显示文摘拓扑的描述符(SATD ) 从与 23 氨基酸有关的 1262 个结构的变量的一个矩阵的原则部件分析导出的氨基酸的分数被采用在不同长度表示 125 肽的结构。量的 sequence-mobilitymodelings (QSMM ) 用部分最少的平方被构造(请) 并且支持向量机器(SVM ) 分别地。作为新氨基酸规模,包括与生物活性有关的丰富的信息的 SATD 容易被操作。更好的结果与获得与的那些相比被获得请,它显示 SVM 介绍了柔韧的稳定性和优秀预兆的能力 forelectrophoretic 活动性。这些结果证明在 QSMM 为应用 ofSATD 和 SVM 回归有宽前景。 | LIANG Guizhao YANG Shanbin ZHOU Yuan ZHOU Peng LI Zhiliang | 2006 | Chinese Science Bulletin2006，51，22： | 4 |
| 5 | Reconstruction of measurements in state estimation strategy against deception attacks for cyber physical systems显示文摘没有已知的州的方程,新州的评价策略被设计对为电子的恶意的攻击是物理系统。由数据重建的想法启发了,(CS ) 压缩察觉到基于系统状态的 Markov 图在察觉和鉴定计划以后被用于剩余大小的重建,它对欺骗攻击增加州的评价策略的跳回。首先, observability 分析被介绍从攻击决定测量重建和损坏水平的被触发的时间。特别地,学习的字典被建议由 K 单个的值分解(K-SVD ) 形成过去完成的字典,它根据测量数据的特征适应地被生产。由于剩余大小的不规则,另外,一个采样矩阵作为测量矩阵被设计。最后,模拟实验在 6 公共汽车力量系统上被执行。大小的重建被建议重建方法完成很好的结果表演,和相应效果分别地基于联合字典和传统的高斯或 Bernoulli 随机的矩阵比重建计划好。特别,当仅仅 29% 可得到的干净大小是左的时,建议策略的性能仍然是非凡的,它为五种恢复算法反映概论。 | Qinxue LI Bugong XU Shanbin LI Yonggui LIU Delong CUI | 2018 | Control Theory and Technology2018，16，1： | 3 |
| 6 | A novel vector of topological and structural information for amino acids and its QSAR applications for peptides and analogues显示文摘A new descriptor, called vector of topological and structural information for coded and noncoded amino acids (VTSA), was derived by principal component analysis (PCA) from a matrix of 66 topological and structural variables of 134 amino acids. The VTSA vector was then applied into two sets of peptide quantitative structure-activity relationships or quantitative sequence-activity modelings (QSARs/ QSAMs). Molded by genetic partial least squares (GPLS), support vector machine (SVM), and immune neural network (INN), good results were obtained. For the datasets of 58 angiotensin converting en-zyme inhibitors (ACEI) and 89 elastase substrate catalyzed kinetics (ESCK) , the R2, cross-validation R2, and root mean square error of estimation (RMSEE) were as follows: ACEI, R2cu≥0.82, Q2cu≥0.77, Ermse≤0.44 (GPLS+SVM); ESCK, R2cu≥0.84, Q2cu≥0.82, Ermse≤0.20 (GPLS+INN), respectively. | LI ZhiLiang LI GenRong SHU Mao SUN JiaYing YANG ShanBin MEI Hu ZHANG MengJun ZHOU Ping WU ShiRong CHEN GuoHua LU FengLin LU TingTing | 2008 | Science China Chemistry2008，51，10： | 2 |
| 7 | Robust fault di- agnosis of networked control system 显示文摘 | SAULTER D LI Shanbin AUBRUN C | 2009 | International Journal of Adaptive Control and SignM Processing2009，23，8： | 1 |
| 8 | Guaranteed cost control for discrete-time networked control systems with random Markov delays显示文摘The guaranteed cost control for a class of uncertain discrete-time networked control systems with random delays is addressed.The sensor-to-controller (S-C) and contraller-to-actuator (C-A) random network-induced delays are modeled as two Markov chains.The focus is on the design of a two-mode-dependent guaranteed cost controller,which depends on both the current S-C delay and the most recently available C-A delay.The resulting closed-loop systems are special jump linear systems.Sufficient conditions for existence of guaranteed cost controller and an upper bound of cost function are established based on stochastic Lyapunov-Krasovakii functions and linear matrix inequality (LMI) approach.A simulation example illustrates the effectiveness of the proposed method. | Li Qiu Bugong Xu Shanbin Li | 2011 | Journal of Systems Engineering and Electronics2011，22，4： | 1 |
| 9 | Scores of amino acid 0D-3D information as applied in cleavage site prediction and better specificity elucidation for human immunodeficiency virus type 1 protease显示文摘A new set of descriptors,namely score vectors of the zero dimension,one dimension,two dimensions and three dimensions(SZOTT),was derived from principle component analysis of a matrix of 1369 structural variables including 0D,1D,2D and 3D information for the 20 coded amino acids. SZOTT scales were then used in cleavage site prediction of human immunodeficiency virus type 1 protease. Linear discriminant analysis(LDA) and support vector machines(SVM) were applied to developing models to predict the cleavage sites. The results obtained by linear discriminant analysis(LDA) and support vector machines(SVM) are as follows. The Matthews correlation coefficients(MCC) by the resubstitution test,leave-one-out cross validation(LOOCV) and external validation are 0.879 and 0.911,0.849 and 0.901,0.822 and 0.846,respectively. The receiver operating characteristic(ROC) analysis showed that the SVM model possesses better simulative and predictive ability in comparison with the LDA model. Satisfactory results show that SZOTT descriptors can be further used to predict cleavage sites of human immunodeficiency virus type 1 protease. | KANG LiFang LIANG GuiZhao SHU Mao YANG ShanBin LI ZhiLiang | 2008 | Science China Chemistry2008，51，8： | 1 |
| 10 | Newapproach to stochastic stability and controller design for networked control systems显示文摘This paper addresses the random time-delays and packet losses issues of networked control systems (NCS) within the framework of jump linear systems with mode-dependent time-delays.A new delay-dependent condition on the stochastic stability is proposed by a new stochastic Lyapunov-Krasovskii functional.The condition is formulated as a set of coupled linear matrix inequalities (LMIs).As an example to verify the proposed method,an inverted-pendulum system with network is considered.The simulation results demonstrate the effectiveness of the method. | Shanbin LI Youxian SUN | 2005 | 控制理论与应用(英文版)2005，3，3： | 1 |
| 11 | Integration of genetic virtual screening patterns and latent multivariate modeling techniques for QSAR optimization based on combinations and/or interactions between peptides and proteins显示文摘Both the concept and the model of snug quantitative structure-activity relationship (QSAR) were pro-posed and developed for molecular design through constructing QSAR based on some known mode of receptor/ligand interactions. Many disadvantages of traditional models can be avoided by using the proposed method because the traditional models only determined upon molecular structural features in sample sets themselves. A genetic virtual screening of peptide/protein combinations (GVSPPC) is proposed for the first time by utilizing this idea to examine peptide/protein affinity activities. A genetic algorithm (GA) was developed for screening combinative targets with an interaction mode for virtual receptors. GVSPPC succeeds in disposing difficulties in rational QSAR,in order to search for the ligand/receptor interactions on conditions of unknown structures. Some bioactive oligo-/poly-peptide systems covering 58 angiotensin converting enzyme (ACE) inhibitors and 18 double site mutation residues in camel antibody protein cAb-Lys3 were investigated by GVSPPC with satisfactory results (R 2 cu>0.91,Q 2 cv > 0.86,ERMS=0.19-0.95),respectively,which demonstrates that GVSPPC is more inter-pretable in the ligand-receptor interaction than the traditional QSAR method. | LI ZhiLiang TIAN FeiFei WU ShiRong YANG ShanBin YANG ShengXi ZHOU Yuan ZHANG QiaoXia QIN RenHui MEI Hu CHEN Gang LI GenRong | 2008 | Science China Chemistry2008，51，5： | 0 |
| 12 | Influence of channel length and layout on TID for 0.18 μm NMOS transistors显示文摘Different channel lengths and layouts on 0.18μm NMOS transistors are designed for investigating the dependence of short channel effects(SCEs)on the width of shallow trench isolation(STI)devices and designing in radiation hardness.Results show that,prior to irradiation,the devices exhibited near–ideal I–V characteristics,with no significant SCEs.Following irradiation,no noticeable shift of threshold voltage is observed,radiation–induced edge–leakage current,however,exhibits significant sensitivity on TID.Moreover,radiation–enhanced drain induced barrier lowering(DIBL)and channel length modulation(CLM)effects are observed on short–channel NMOS transistors.Comparing to stripe–gate layout,enclosed–gate layout has excellent radiation tolerance. | WU Xue LU Wu WANG Xin GUO Qi HE Chengfa LI Yudong XI Shanbin SUN Jing WEN Lin | 2013 | Nuclear Science and Techniques2013，24，6： | 0 |
| 13 | Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis显示文摘Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA. | LIANG GuiZhao CHEN ZeCong YANG ShanBin MEI Hu ZHOU Yuan YANG Li ZHOU Peng YANG ShengXi SHU Mao LIAO ChunYang WU ShiRong LI GenRong HE Liu GAO JianKun Gan MengYu LI DeJing CHEN GuoPing WANG GuiXue LONG Sha JING JuHua ZHENG XiaoLin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo WANG JiaoNa LIU YongHong LI Bo QIU LiangJia CAI ShaoXi ZHAO Na YANG Yan SU XiaLi SONG Jian CHEN MeiXia ZHANG XueJiao SUN JiaYing LI JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU LuoNan WU YuQuan LIAO LiMin LI Zhi LI Jun LU DaJun SU QinLiang HUANG ZhengHu ZHOU Ping LI ZhiLiang | 2008 | Science China Chemistry2008，51，2： | 0 |
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