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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyetbylene oxide blends 显示文摘 | Norries I D Shaker M M Ko F K | 2000 | Synth Met2000，114，： | 1 |
| 3 | Parental attitudes toward breastfeeding: their association with feeding outcome at hospital discharge显示文摘 | Scott JA Shaker I Reid M | 2004 | Birth2004，31，2： | 1 |
| 4 | The effects of busi- ness-university alliances on innovative output and finan- cial performance:A study of publicly traded bio-tech- nology显示文摘 | George G Shaker A I Jr Wood D | 2002 | Joumal of Business Venturing2002，17，6： | 1 |
| 5 | Improvement of the interfacial adhesion between kevlar fiber and resin by using R- F plasma显示文摘 | SHAKER M KAMEL I KO F | 1996 | Journal of Materials Technology h-Research1996，18，4： | 1 |
| 6 | Electrostatic fabrication of ultrafine conducting fibers:polyaniline/polyethylene oxide blends显示文摘 | NORRIS I D SHAKER M M FRANK K | 2000 | Synthetic Materials2000，114，： | 1 |
| 7 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyethylene oxide blends 显示文摘 | Norris I D Shaker M M Ko F K et aI | 2000 | Synthetic Metals2000，114，： | 1 |
| 8 | Electrostatic fabrication of ultraiine conducting fibers: Polyaniline/polyethylene oxide blends 显示文摘 | Norris I D Shaker M M Ko F K | 2000 | Synthetic Metals2000，114，1： | 1 |
| 9 | The influence of the golden 24 - h rule'on the prognosis of esophageal perforation in the modem era显示文摘 | Shaker H Elsayed H Whittle I | 2010 | Eur J Cardiothoracic Surg2010，38，2： | 1 |
| 10 | Improvement of interfacial adhesion between kevlar fiber and resin by using R-F plasma显示文摘 | SHAKER M KAMEL I KO F | 1996 | Journal of Composites Technology & Research1996，18，4： | 1 |
| 11 | Infant feeding attitudes of expectant parents:breastfeeding and formula feeding显示文摘 | Shaker I Scott JA Reid M | 2004 | J Adv Nurs2004，45，3： | 1 |
| 12 | Effect of treat- ment with metforminon omentin-1, ghrelin and other biochemi- cal, clinical features in PCOS patients 显示文摘 | SHAKER M MASHHADANI Z I MEHDI A A | 2010 | Oman Med2010，25，4： | 1 |
| 13 | Improvement of the Interfacial Adhesion between Kevlar Fiber and Resin by Using R-F Plasma显示文摘 | Shaker M Kamel I Ko F | 1996 | Journal of Composites Technology & Research1996，18，4： | 1 |
| 14 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/pelyethylene oxide blends 显示文摘 | Norris I D Shaker M M Ko F K | 2000 | Synth Met2000，114，： | 1 |
| 15 | Electrostatic fabrication of uhrafine conducting fibers : polyaniline/polyethylene oxide blends 显示文摘 | NORRIS I D SHAKER M M KO F F | 2000 | Synthetic Metals2000，114，2： | 1 |
| 16 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyethylene oxide blends显示文摘 | Norris I D Shaker M M Ko F K | 2000 | Synthetic Metals2000，114，2： | 1 |
| 17 | Analysis of fine structure and biochemical changes of retina during aging of W istar albino rats显示文摘 | Hassan IH El‐Sayyad Soad A Khalifa Fawkia I El‐Sayyad Shaker A Mousa Ezaldin AM Mohammed | 2014 | Clin Experiment Ophthalmol2014，，2： | 1 |
| 18 | The influence of the 'golden 24 h rule' on the progmosisofoesophageal perforation in the modem era 显示文摘 | Shaker H Elsayed H Whittle I | 2010 | European Journal ofCardio-thoracic SurgelT2010，38，2： | 1 |
| 19 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyethylene oxide blends显示文摘 | Norris I D Shaker DM Frank K K | | 0，，： | 1 |
| 20 | Infant feeding attitudes of expectant parents:breastfeeding and formula feeding显示文摘 | Shaker I Scott JA Reid M | | 0，，03： | 1 |
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