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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | International corporate entrepreneurship and firm performance显示文摘 | Shaker A Zahra Dennis M Garvis | 2000 | Journal of Business Venturing2000，，5： | 3 |
| 3 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyetbylene oxide blends 显示文摘 | Norries I D Shaker M M Ko F K | 2000 | Synth Met2000，114，： | 1 |
| 4 | Application of high-resolution Stereo satellite images to detailed landslide hazard assessment 显示文摘 | Nichl J E Shaker A Wong M S | 2006 | GeogTaphology2006，76，12： | 1 |
| 5 | Probiotic yogurt affects pro-and anti-inflammatory factors in patients with inflammatory bowel disease显示文摘 | Shadnoush M Shaker Hosseini R Mehrabi Y | 2013 | Iranian journal of pharmaceutical research2013，12，4： | 1 |
| 6 | Momparler,preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza 2-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells显示文摘 | Shaker S Bernstein M Momparler L F | 2003 | Leuk Res2003，27，5： | 1 |
| 7 | Quantitative analysis of pulmonary emphysema using local binary patterns显示文摘 | Sorensen L Shaker SB de Bruijne M | 2010 | IEEE Trans Med Imaging2010，29，2： | 1 |
| 8 | Parental attitudes toward breastfeeding: their association with feeding outcome at hospital discharge显示文摘 | Scott JA Shaker I Reid M | 2004 | Birth2004，31，2： | 1 |
| 9 | Electrostatic Fabrication of Ultrafine Cinducting Fibers: Polyaniline/Polyethylene Oxide Blends显示文摘 | NORR IS D SHAKER M M FRANK K K | 2000 | Synthetic Metals2000，114，23： | 1 |
| 10 | Millimeter-wave Talbot array illuminators 显示文摘 | M G Keller J Shaker Y M M Antar | 2006 | IEEE Antennas and Wireless Propagation Letters2006，5，1： | 1 |
| 11 | Electrostatic fabrication of ultrafine conducting fibers:polyaniline/polyethylene oxide blends显示文摘 | Ian D Norris Manal M Shaker Frank K | 2000 | Synthetic Materials2000，114，： | 1 |
| 12 | Thermodynamics of metal cation binding by a solid soil-derived humic acid:Binding of Fe(Ⅲ),Pb(Ⅱ),and Cu(Ⅱ)显示文摘 | Ghabbour E A Shaker M El-toukhy A | 2006 | Chemosphere2006，63，3： | 1 |
| 13 | Early diagnostic markers fbr contrast nephropathy in patients undergoing coronary angiography 显示文摘 | Shaker OG E1-Shehaby A E1-Khatib M | 2010 | Angiology2010，61，8： | 1 |
| 14 | Study of omentinl and other adipokines and hormones in PCOS patients显示文摘 | Mahde A Shaker M A1-Mashhadani Z | 2009 | Oman Ned J2009，24，2： | 1 |
| 15 | Possible role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as markers of plaque instability in coronary显示文摘 | Shaker G Ei-Shehaby A Nabih M | 2010 | Angiology2010，61，8： | 1 |
| 16 | Improvement of the interfacial adhesion between kevlar fiber and resin by using R- F plasma显示文摘 | SHAKER M KAMEL I KO F | 1996 | Journal of Materials Technology h-Research1996，18，4： | 1 |
| 17 | Broadband reflectarray antenna with double cross loops显示文摘 | M R Chaharmir J Shaker M Cuhaci | 2006 | Electronics Letters2006，42，2： | 1 |
| 18 | Springback and residual stresses after stretch bending of work harden- ing sheet metal 显示文摘 | Meqharbel A Domiaty A Shaker M | 1990 | Journal of Materials Processing Technology1990，24，： | 1 |
| 19 | Novel Photonically-Controlled Reflectarray Antenna显示文摘 | M R Chaharmir J Shaker M Cuhaci | 2006 | IEEE Trans on Antennas and Propagation2006，54，4： | 1 |
| 20 | Electrostatic fabrication of ultrafine conducting fibers:polyaniline/polyethylene oxide blends显示文摘 | NORRIS I D SHAKER M M FRANK K | 2000 | Synthetic Materials2000，114，： | 1 |
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