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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Translational perspective: is cinnamon a suitable agent for cognitive impairment and Alzheimer’s disease associated with brain trauma?显示文摘Cinnamon, is an exotic spice and a major constituent of our food which is commonly used in different areas of the world for the treatment of various diseases (Kawatra et al., 2015). Besides 让s anti-inflammatory, anti-diabetic and anti-cancer properties, cinnamon also exerts strong brain protective and pro-cogrdtive effects in various models of neurodegeneration (Kawatra et al., 2015;Kelestemur et al., 2016)(Figure 1). | Burak Yulug Seyda Cankaya | 2019 | Neural Regeneration Research2019，14，8： | 5 |
| 3 | Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms显示文摘 | Ozlem Atli Merve Baysal Gozde Aydogan-Kilic Volkan Kilic Seyda Ucarcan Burak Karaduman Sinem Ilgin | 2017 | Asian Journal of Andrology2017，19，6： | 4 |
| 4 | Artificial intelligence and kidney transplantation显示文摘Artificial intelligence and its primary subfield,machine learning,have started to gain widespread use in medicine,including the field of kidney transplantation.We made a review of the literature that used artificial intelligence techniques in kidney transplantation.We located six main areas of kidney transplantation that artificial intelligence studies are focused on:Radiological evaluation of the allograft,pathological evaluation including molecular evaluation of the tissue,prediction of graft survival,optimizing the dose of immunosuppression,diagnosis of rejection,and prediction of early graft function.Machine learning techniques provide increased automation leading to faster evaluation and standardization,and show better performance compared to traditional statistical analysis.Artificial intelligence leads to improved computer-aided diagnostics and quantifiable personalized predictions that will improve personalized patient care. | Nurhan Seyahi Seyda Gul Ozcan | 2021 | World Journal of Transplantation2021，11，7： | 2 |
| 5 | Thermal and microstructural characterization of a novel ductile cast iron modified by aluminum addition显示文摘In high-temperature applications,like exhaust manifolds,cast irons with a ferritic matrix are mostly used.However,the increasing demand for higher-temperature applications has led manufacturers to use additional expensive materials such as stainless steels and Ni-resist austenitic ductile cast irons.Thus,in order to meet the demand while using low-cost materials,new alloys with improved high-temperature strength and oxidation resistance must be developed.In this study,thermodynamic calculations with Thermo-Calc software were applied to study a novel ductile cast iron with a composition of 3.5wt%C,4wt%Si,1wt%Nb,0‒4wt%Al.The designed compositions were cast,and thermal analysis and microstructural characterization were performed to validate the calculations.The lowest critical temperature of austenite to pearlite eutectoid transformation,i.e.,A1,was calculated,and the solidification sequence was determined.Both calculations and experimental data revealed the importance of aluminum addition,as the A1 increased by increasing the aluminum content in the alloys,indicating the possibility of utilizing the alloys at higher temperature.The experimental data validated the transformation temperature during solidification and at the solid state and confirmed the equilibrium phases at room temperature as ferrite,graphite,and MC-type carbides. | Gülsah Aktas Celik Maria-Ioanna TTzini Seyda Polat SHakan Atapek Gregory NHaidemenopoulos | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，2： | 2 |
| 6 | Fast kernel classifiers with online and active learning显示文摘 | Antoine Bordes Seyda Ertekin Jason Westou | 2005 | J of Machine Learning Research2005，6，9： | 1 |
| 7 | Neoangiogenesis and expression of hypoxia-inducible factor 1α, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas显示文摘 | Irem Hicran Ozbudak Seyda Karaveli Tayyup Simsek Gulgun Erdogan Elif Pestereli | 2007 | Gynecologic Oncology2007，，3： | 1 |
| 8 | Enzymatic production of xylooligosaccharide from selected agricultural wastes 显示文摘 | OZLEM A KADER E SEYDA B | 2009 | Food Bioproduction Process2009，87，： | 1 |
| 9 | In vitro amoebicidal activities of Teucrium polium and T. chamaedrys on Acanthamoeba castellanii trophozoites and cysts显示文摘 | Bektas Tepe Erdogan Malatyali Serpil Degerli Seyda Berk | 2012 | Parasitology Research2012，，： | 1 |
| 10 | Production of xylooligosac- charides by controlled acid hydrolysis of lignocellulosic materials 显示文摘 | OZLEM A KADER E SEYDA B | 2009 | Carbohydrate Research2009，344，： | 1 |
| 11 | A novel syndrome affecting multiple mitochondrial functions, located by microcell - mediated transfer to chromosome 2p14- 2p13显示文摘 | Seyda A Newbold RF Hudson TJ | 2001 | Am J Hum Genet2001，68，： | 1 |
| 12 | Free amino acid profiling in the giant puffball mushroom (Calvatia gigantea) using UPLC-MS/MS显示文摘 | Ibrahim K?vrak Seyda K?vrak Mansur Harmandar | 2014 | ?Food Chem2014，158，1： | 1 |
| 13 | Production of xylooligosaccharides by controlled acid hydrolysis of lignocellulosic materials 显示文摘 | OZLEM A KADER E SEYDA B | 2009 | Carbohyd Res2009，344，2： | 1 |
| 14 | A modified shifting bottleneck heuristic for the reentrant job shop scheduling problem with makespan minimization 显示文摘 | SEYDA T GAMZE K | 2009 | The International Journal of Advanced Manufacturing Technology2009，44，7： | 1 |
| 15 | Effects of radiation therapy on oesophageal transit patients with inner quadrant breast tumour显示文摘 | Seyda T Tamer A Muge A | 2005 | Nucl Med Commun2005，26，8： | 1 |
| 16 | Enzymatic pro- duction of Xylooligosaccharide from selected agricultural wastes显示文摘 | Ozlem Akpinar Kader Erdogan Seyda Bostanci | 2009 | Food and Bioproducts Processing2009，87，2： | 1 |
| 17 | Prognostic significance of EBV-LMP1· and VEGF-A, Expressions in non-Hodgkin's lymphomas显示文摘 | Paydas Semra Ergin Melek Erdogan Seyda | 2008 | Leuk Res2008，21，7： | 1 |
| 18 | Detection of a homozygous four base pair deletion in the protein X gene in a case of pyruvate dehydrogenase complex deficiency显示文摘 | Ling M Mceachem G Seyda A | 1998 | Hum Mol Genet1998，7，3： | 1 |
| 19 | A Simulated Annealing Algorithm for the Job Shop Cell Scheduling Problem with In- tercellular Moves and Reentrant Parts显示文摘 | Atabak E Maghsud S Seyda T Afshin E | 2011 | Computers & Industrial Engineering2011，61，1： | 1 |
| 20 | Classifiers with Online and Active Learning显示文摘 | Antoine Bordes Seyda Ertekin Jason Weston Leon Bottou Fasl Kernel | | 0，，06： | 1 |
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