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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Isolation and Expression Analysis of Two Genes Encoding Cinnamate 4-Hydroxylase from Cotton(Gossypium hirsutum)显示文摘Two genes(GhC4H1 and GhC4H2) that encode putative cotton cinnamate 4-hydroxylases that catalyze the second step in the phenylpropanoid pathway were isolated from developing cotton fibers. GhC4H1 and GhC4H2 each contain open reading frames of 1 518 base pairs(bp) in length and both encode proteins consisting of 505 amino acid residues. They are 90.89% identical to each other at the amino acid sequence level and belong to class I of plant C4 Hs. GhC4H1 and GhC4H2 genomic DNA are 2 247 and 2 161 bp long, respectively, and contain two introns located at conserved positions relative to the coding sequence. GhC4H1 and GhC4H2 promoters were isolated and found to contain many cis-elements(boxes P, L and AC-I element) previously identified in the promoters of other phenylpropanoid pathway genes. Histochemical staining showed GUS expression driven by the GhC4H1 and GhC4H2 promoters in ovules and fibers tissues. GhC4H1 and GhC4H2 were also widely expressed in other cotton tissues. GhC4H2 expression reached its highest level during the elongation stage of fiber development, whereas GhC4H1 expression increased during the secondary wall development period in cotton fibers. Our results contribute to a better understanding of the biochemical role of GhC4H1 and GhC4H2 in cotton fiber development. | NI Zhi-yong LI Bo Neumann M Peter Lü Meng FAN Ling | 2014 | Journal of Integrative Agriculture2014，13，10： | 3 |
| 3 | All-optical controlled-NOT logic gate achieving directional asymmetric transmission based on metasurface doublet显示文摘Optical logic gates play important roles in all-optical logic circuits,which lie at the heart of the next-generation optical computing technology.However,the intrinsic contradiction between compactness and robustness hinders the development in this field.Here,we propose a simple design principle that can possess multiple-input-output states according to the incident circular polarization and direction based on the metasurface doublet,which enables controlled-NOT logic gates in infrared region.Therefore,the directional asymmetric electromagnetic transmission can be achieved.As a proof of concept,a spin-dependent Janus metasurface is designed and experimentally verified that four distinct images corresponding to four input states can be captured in the far-field.In addition,since the design method is derived from geometric optics,it can be easily applied to other spectra.We believe that the proposed metasurface doublet may empower many potential applications in chiral imaging,chiroptical spectroscopy and optical computing. | Yijia Huang Tianxiao Xiao Shuai Chen Zhengwei Xie Jie Zheng Jianqi Zhu Yarong Su Weidong Chen Ke Liu Mingjun Tang Peter Müller-Buschbaum Ling Li | 2023 | Opto-Electronic Advances2023，6，7： | 2 |
| 4 | Regional differences in health status in China: Population health-related quality of life results from the National Health Services Survey 2008显示文摘 | Sun Sun Jiaying Chen Magnus Johannesson Paul Kind Ling Xu Yaoguang Zhang Kristina Burstr?m | 2011 | Health and Place2011，，2： | 2 |
| 5 | Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden,development of airspace enlargement,and pulmonary Inflammation in mice显示文摘 | Christensen P J Preston A M Ling T | 2008 | Infect Immun2008，76，8： | 1 |
| 6 | Down-regulation of intrinsic P-glycoprotein expression in Down-regula- tion of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species显示文摘 | Ling F C Schallenberg M | 2001 | J Biol Chem2001，276，17： | 1 |
| 7 | The B7 family of ligands and its receptors : New pathways for costimulation and inhibition of immune responses显示文摘 | Collins M Ling V Carreno BM | 2002 | Annu Rev Immunol2002，20，： | 1 |
| 8 | High-dose intravenows gammaglobulin therap for neonatal autoimmune 显示文摘 | BALLIN A ANDREW M LING E | 1998 | Thrombocytopenia J Pediatr1998，112，： | 1 |
| 9 | Ambidexterity and Perform-ance in Small-to-medium-sized Firms:The Pivotal Role of TopManagement Team Behavioral Integration显示文摘 | Lubatkin M H Simsek Z Ling Y | 2006 | J Manage2006，32，64： | 1 |
| 10 | Contrasting geochemical and Sm- Nd isotopic compositions of Archean metasediments from the Kongling high-grade terrain of the Yangtze craton: Evidence for cra- tonic evolution and redistribution of REE during crustal anatexis显示文摘 | Gao S Ling W L Qiu Y M | 1999 | Geochimica et Cosmochimica Acta1999，63，1314： | 1 |
| 11 | Effects of expand- able graphite and ammonium polyphosphate on the flame-re- tardant and mechanical properties of rigid polyurethane fimms 显示文摘 | XIAN Y M LING Y XIAO G Z | 2009 | JApplPolymSci2009，114，： | 1 |
| 12 | Genetic analysis of cold tolerance dur-ing vegetative growth in tomato,Lycopersicon esculentum Mill显示文摘 | FOOLAD M R LING Y | 2001 | Euphytica2001，，122： | 1 |
| 13 | Multi-user MIMO with limited feedback using alternating codebooks 显示文摘 | Jiang Cheng Ling Wang M M Shu Feng | 2012 | IEEE Transactions on Communications2012，60，2： | 1 |
| 14 | Clinical otteome of mi/ral regurgitulion due to flail leaflet 显示文摘 | Ling LH Emiluez-Sav+ano M Seward JB | 1996 | N Engl J Med1996，335，19： | 1 |
| 15 | Decreased microRNA-206 and its function in cervical cancer 显示文摘 | Ling S Ruiqin M Guohong Z | 2015 | Eur J Gynaecol Oncol2015，36，6： | 1 |
| 16 | Intemal Marketing and Customer Driven Wavefronts显示文摘 | Brooks R F I N Lings M A Botschen | 1999 | The Service Industries Journal1999，19，4： | 1 |
| 17 | The shear strength of trabecular bone from the femur, and some factors affecting the shear strength of the cement - bone interface 显示文摘 | Lee AJC Ling RSM | 1978 | Arch Orthop Trauma Surg1978，92，： | 1 |
| 18 | Carbon taxation policy in china: how to protect energy-and trade-intensive sector? 显示文摘 | Ling Q M Fan Y Wei Y M | 2007 | Journal of Policy Modeling2007，29，2： | 1 |
| 19 | Comparison of cer- ebral blood volume and permeability in preoperative grading of intraeranial glioma using CT perfusion imaging 显示文摘 | DING B LING H W CHEN K M | 2006 | Neurora- diology2006，48，10： | 1 |
| 20 | Acousto-Optic Tunable Flters: Fundamentals and Applications as Applied to Chemical Analysis Techniques显示文摘 | Ling B Glenn I D Heather M M | 2004 | Progress in Quantum Electronics2004，，28： | 1 |
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