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| 1 | Effects of interventions on oxidative stress and inflammation of cardiovascular diseases显示文摘Excessive oxidative stress and low-grade chronic inflammation are major pathophysiological factors contributing to the development of cardiovascular diseases (CVD) such as hypertension, diabetes and atherosclerosis. Accumulating evidence suggests that a compromised antioxidant system can lead to excessive oxidative stress in cardiovascular related organs, resulting in cell damage and death. In addition, increased circulating levels of pro-inflammatory cytokines, such as tumor necrosis factor α, interleukin-6 and C-reactive protein, are closely related to morbidity and mortality of cardiovascular complications. Emerging evidence suggests that interventions including nutrition, pharmacology and exercise may activate expression of cellular anti-oxidant systems via the nuclear factor erythroid 2-related factor 2-Kelchlike ECH-associated protein 1 signaling pathway and play a role in preventing inflammatory processes in CVD. The focus of the present review is to summarize recent evidence showing the role of these anti-oxidant and anti-inflammatory interventions in cardiovascular disease. We believe that these findings may prompt new effective pathogenesis-oriented interventions, based on the exercise-induced protection from disease in the cardiovascular system, aimed at targeting oxidant stress and inflammation. | Sewon Lee Yoonjung Park Mozow Yusof Zuidema Mark Hannink | 2011 | World Journal of Cardiology2011，3，1： | 23 |
| 2 | 城市区域尺度下多中心空间结构的经济绩效影响显示文摘文章基于2004—2018年山东半岛城市群内六大都市圈和都市区面板数据,运用空间杜宾模型实证检验了城市区域尺度下多中心空间结构对经济绩效的影响。研究表明:①虽然城市区域尺度下的形态多中心空间结构对经济绩效提升的作用效果不显著,但功能多中心空间结构却能够通过空间溢出效应促进区域经济的发展。②不同的都市圈(区)功能多中心空间结构的本地直接效应与城际间接效应存在明显差异,济南都市圈、青岛都市圈和烟威都市区空间结构上的功能多中心化不仅能够促进本地经济绩效的提升,也有利于邻近城市经济绩效的提高;东滨都市区功能多中心化水平的提高仅能够促进本地经济绩效的提升,城际溢出效应尚未显现;济枣菏和临日都市区功能多中心化程度的提高反而会对周边城市的经济发展产生不利影响,形成“虹吸效应”。③从不同规模城市空间溢出效应的异质性表现来看,仅有中等规模城市可以带动周边地区同等规模城市的发展,而小城市并不必然产生显著的正外部性。因此,在山东半岛城市群范围内应统筹推进中心城市与其所在的都市圈(区)等城市区域尺度下多中心城市网络格局的持续优化,构建功能互补、协同高效的多中心空间结构体系,以更加有效地提升区域经济发展绩效水平,助力区域经济高质量发展。 | 李顺成 LEE Sewon 刘晓晨 | 2021 | 中国人口·资源与环境2021，31，11： | 7 |
| 3 | Hunt for the tipping point during endocrine resistance process in breast cancer by dynamic network biomarkers显示文摘Acquired drug resistance is the major reason why patients fail to respond to cancer therapies.It is a challenging task to deter.mine the tipping point of endocrine resistance and detect the associated molecules.Derived from new systems biology theory, the dynamic network biomarker (DNB) method is designed to quantitatively identify the tipping point of a drastic system transition and can theoretically identify DNB genes that play key roles in acquiring drug resistance.We analyzed time-course mRNA sequence data generated from the tamoxifen-treated estrogen receptor (ER)-positive MCF-7 cell line, and identified the tipping point of endocrine resistance with its leading molecules.The results show that there is interplay between gene mutations and DNB genes, in which the accumulated mutations eventually affect the DNB genes that subsequently cause the change of transcriptional landscape, enabling full-blown drug resistance. Survival analyses based on clinical datasets validated that the DNB genes were associated with the poor survival of breast cancer patients.The results provided the detection for the pre-resistance state or early signs of endocrine resistance.Our predictive method may greatly benefit the scheduling of treatments for complex diseases in which patients are exposed to considerably different drugs and may become drug resistant. | Rui Liu Jinzeng Wang Masao Ukai Ki Sewon Pei Chen Yutaka Suzuki Haiyun Wang Kazuyuki Aihara Mariko Okada-Hatakeyama Luonan Chen | 2019 | Journal of Molecular Cell Biology2019，11，8： | 7 |
| 4 | New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group显示文摘 | Diane Thiboutot Harald Gollnick Vincenzo Bettoli Brigitte Dréno Sewon Kang James J. Leyden Alan R. Shalita Vicente Torres Lozada Diane Berson Andrew Finlay Chee Leok Goh María Isabel Herane Ana Kaminsky Raj Kubba Alison Layton Yoshiki Miyachi Montserrat P | 2009 | Journal of the American Academy of Dermatology2009，，5： | 2 |
| 5 | A prospective study onsucrose consumption, visible plaque and caries in children from 3 to6 years of age 显示文摘 | Karjaiainen S Soderiing E Sewon L | 2001 | Community Dent Oral Epidemiol2001，29，2： | 1 |
| 6 | Photoaging Pathogenesis , Prevention, and Treatment 显示文摘 | Sewon Kang Gray J Fisher John J Voorehees | 2001 | Clinical in Geriatric Medicine2001，4，17： | 1 |
| 7 | Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin显示文摘 | TaiHao Quan TianYuan He Yuan Shao Lin Lin Sewon Kang John J. Voorhees Gary J. Fisher | 2006 | The American Journal of Pathology2006，，2： | 1 |
| 8 | Determinants and consequences of voluntary dis- closure in an emerging market: Evidence from China显示文摘 | Wang K Sewon O Claiborne M C | 2008 | Journal of International Accounting Auditing and Taxation2008，17，1： | 1 |
| 9 | A randomized, controlled, split-face clinical trial of 1320nm Nd:YAG laser therapy in the treatment of acne vulgaris显示文摘 | Jeffrey S Sewon K Lisa M | 2007 | Am Acad Dermatol2007，56，： | 1 |
| 10 | Associations between salivary calcium and oral health 显示文摘 | Karjalainen SM Soderling E | 1998 | J Clin Periodontal1998，25，： | 1 |
| 11 | A randomized,controlled,split-face clinical trial of 1 320nm Nd:YAG laser therapy in the treatment of acne vulgaris显示文摘 | Jeffrey S Sewon K Lisa M | 2007 | Am Acad Dermatol2007，56，： | 1 |
| 12 | A study of the possible correlation of high salivary calcium levels with periodontal and dental conditions in young adults显示文摘 | Makela M | 1990 | Arch Oral Biol1990，35，： | 1 |
| 13 | Determinants and consequences of voluntary disclosure in an emerging market: Evidence from China显示文摘 | Kun Wang Sewon O M. Cathy Claiborne | 2008 | Journal of International Accounting Auditing and Taxation2008，，1： | 1 |
| 14 | Role of adiponectin in metabolic and cardiovascular disease显示文摘 | Sewon L Hyo-Bum K | 2014 | Exerc Rehabil2014，10，2： | 1 |
| 15 | Lightning Overvoltage Protection of AC Railroad Vehicles by Polymeric Arresters 显示文摘 | Jinliang He Sewon Han Hangoo Cho | 1999 | IEEE Transactions on Power Delivery1999，14，4： | 1 |
| 16 | Photoaging and topical tretinoin显示文摘 | Sewon K Gary J | 1997 | Arch Dermatol1997，133，10： | 1 |
| 17 | Differences in firmness,sugars and organic acids contents of cucumber fruitbased on size显示文摘 | Park Sewon Chi SoungHan | 2002 | Journal of the Korean Society for horticultural science2002，43，： | 1 |
| 18 | Lightning Overvoltage Protection of AC Railroad Vehicles by Polymeric Arresters显示文摘 | Sewon Hah Hangoo Cho | 1999 | IEEE Transactions on Power Delivery1999，14，4： | 1 |
| 19 | Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-KB and activator protein-1 in inflammatory acne lesions in vivo显示文摘 | Sewon K Soyun C Jin HC | | 0，，： | 1 |
| 20 | Adiponectin abates diabetes- induced endothelial dysfunction by suppressing oxidative stress, adhesion molecules, and inflammation in type 2 diabetic mice 显示文摘 | Sewon Lee Hanrui Zhang Cuihua Zhang | 2012 | Am J Physiol Heart Circ Physiol2012，303，： | 1 |
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