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| 1 | Efficacy of transcatheter embolization/chemoembolization (TAE/TACE) for the treatment of single hepatocellular carcinoma显示文摘AIM:To investigate the efficacy of transcatheter embolization/chemoembolization (TAE/TACE) in cirrhotic patients with single hepatocellular carcinoma (HCC) not suitable for surgical resection and percutaneous ablation therapy. METHODS:A cohort of 176 consecutive cirrhotic patients with single HCC undergoing TAE/TACE was reviewed; 162 patients had at least one image examination (helical CT scan or triphasic contrastenhanced MRI) after treatment and were included into the study. TAE was performed with Lipiodol followed by Gelfoam embolization; TACE was performed with Farmorubicin prepared in sterile drip at a dose of 50 mg/m2,infused over 30 min using a peristaltic pump,and followed by Lipiodol and Gelfoam embolization. RESULTS:Patients characteristics were:mean age,62 years; male/female 117/45; Child-Pugh score 6.2 ± 1.1; MELD 8.7 ± 2.3; mean HCC size,3.6 (range 1.0-12.0) cm. HCC size class was ≤ 2.0 cm,n = 51; 2.1-3.0 cm,n = 35; 3.1-4.0 cm,n = 29; 4.1-5.0 cm,n = 22; 5.1-6.0 cm,n = 11; and > 6.0 cm,n = 14. Patients received a total of 368 TAE/TACE (mean 2.4 ± 1.7). Complete tumor necrosis was obtained in 94 patients (58%),massive (90%-99%) necrosis in 16 patients (10%),partial (50%-89%) necrosis in 18 patients (11%) and poor (< 50%) necrosis in the remaining 34 patients (21%). The rate of complete necrosis according to the HCC size class was:69%,69%,52%,68%,50% and,13% for lesions of ≤ 2.0,2.1-3.0,3.1-4.0,4.1-5.0,5.1-6.0,and > 6.0 cm,respectively. Kaplan-Mayer survival at 24-mo was 88%,68%,59%,59%,45%,and 53% for lesions of ≤ 2.0,2.1-3.0,3.1-4.0,4.1-5.0,5.1-6.0,and > 6.0 cm,respectively. CONCLUSION:Our study showed that in cirrhotic patients with single HCC smaller than 6.0 cm,TAE/TACE produces complete local control of tumor in a significant proportion of patients. TAE/TACE is an effective therapeutic option in patients with single HCC not suitable for surgical resection or percutaneous ablation therapies. Further studies should investigate if the new available embolization agents or drug eluting beads may improve the effect on tumor necrosis. | Roberto Miraglia Giada Pietrosi Luigi Maruzzelli Ioannis Petridis Settimo Caruso Gianluca Marrone Giuseppe Mamone Giovanni Vizzini Angelo Luca Bruno Gridelli | 2007 | World Journal of Gastroenterology2007，13，21： | 38 |
| 2 | Interventional radiology procedures in adult patients who underwent liver transplantation显示文摘Interventional radiology has acquired a key role in every liver transplantation(LT)program by treating the majority of vascular and non-vascular post-transplant complications,improving graft and patient survival and avoiding,in the majority of cases,surgical revision and/or re-transplantation.The aim of this paper is to review indications,technical consideration,results achievable and potential complications of interventional radiology procedures after deceased donor LT and living related adult LT. | Roberto Miraglia Luigi Maruzzelli Settimo Caruso Mariapina Milazzo Gianluca Marrone Giuseppe Mamone Vincenzo Carollo Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 3 | Multidisciplinary imaging of liver hydatidosis显示文摘Liver hydatidosis is a parasitic endemic disease affecting extensive areas in our planet,a significant stigma within medicine to manage because of its incidence,possible complications,and diagnostic involvements.The diagnosis of liver hydatidosis should be as fast as possible because of the relevant complications that may arise with disease progression,involving multiple organs and neighboring structures causing disruption,migration,contamination.The aim of this essay is to illustrate the role of imaging as ultrasonography(US),multi detector row computed tomography,and magnetic resonance imaging(MRI)in the evaluation of liver hydatidosis:the diagnosis,the assessment of extension,the identification of possible complications and the monitoring the response to therapy.US is the screening method of choice.Computed tomography(CT)is indicated in cases in which US is inadequate and has high sensitivity and specificity for calcified hydatid cysts.Magnetic resonance is the best imaging procedure to demonstrate a cystic component and to show a biliary tree involvement.Diagnostic tests such as CT and MRI are mandatory in liver hydatidosis because they allow thorough knowledge regarding lesion size,location,and relations to intrahepatic vascular and biliary structures,providing useful information for effective treatment and decrease in post-operative morbidity.Hydatid disease is classified into four types on the basis of their radiologic appearance. | Gianluca Marrone Francesca Crino' Settimo Caruso Giuseppe Mamone Vincenzo Carollo Mariapina Milazzo Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2012 | World Journal of Gastroenterology2012，18，13： | 10 |
| 4 | Imaging in liver transplantation显示文摘The aim of this study was to illustrate the role of noninvasive imaging tools such as ultrasonography,multidetector row computed tomography,and magnetic resonance imaging in the evaluation of pediatric and adult liver recipients and potential liver donors,and in the detection of potential complications arising from liver transplantation. | Settimo Caruso Roberto Miraglia Luigi Maruzzelli Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 8 |
| 5 | Complete spontaneous regression of giant focal nodular hyperplasia of the liver: Magnetic resonance imaging evaluation with hepatobiliary contrast media显示文摘Focal nodular hyperplasia(FNH) of the liver is a benign lesion occurring in 0.6%-3% of the general population that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Most lesions are diagnosed incidentally and the natural history of the disease remains largely unknown. It has been shown that most FNH remain stable, or even regress, over a long follow-up period. We present a patient with FNH of the liver who was followed up for 7 years. A 26-yearold woman with a 5-year history of oral contraceptive use was referred to our hospital in February 2005 for further examination of a liver tumour. The diagnosis of FNH was made using magnetic resonance(MR) imaging with hepatospecific contrast media; this technique allows a correct diagnosis, in particular distinguishing FNH from hepatic adenoma, avoiding an invasive procedure such as the lesion biopsy. After 7-year from the diagnosis, we observed the complete spontaneous regression of the lesion by enhanced MR scanning. In this patient, discontinuation of oral contraceptive use and two childbirths may have influenced the natural history of FNH. To our knowledge, in the English literature there is no report illustrating a complete regression of giant FNH but only studies of decreasing in size. The present case suggests that a young patient with giant FNH should be managed conservatively rather than by resection, because FNH has the potential for spontaneous regression. | Giuseppe Mamone Settimo Caruso Kelvin Cortis Roberto Miraglia | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 6 | Huge extrahepatic portal vein aneurysm as a late complication of liver transplantation显示文摘A 60-year-old male underwent orthotopic liver trans- plantation because of hepatitis C virus related cirrhosis. After 12 d,the patient underwent re-transplantation due to primary graft non function.One year later the patient developed a thrombosis of the main portal vein needing a surgical revision.After 11 years the patient was operated on because of a clinical picture of intestinal occlusion.As an incidental finding,a large aneurysm of the main portal vein was diagnosed.The incidence of intra-and extrahepatic Portal vein aneurysms(PVAs) is not clear.To the best of our knowledge,only one case of intrahepatic PVA in a liver transplant has been reported in the literature.In addition,we have found no documented cases of extrahepatic PVAs in liver transplanted patients. | Fabrizio di Francesco Salvatore Gruttadauria Settimo Caruso Bruno Gridelli | 2010 | World Journal of Hepatology2010，2，5： | 3 |
| 7 | MDCT, MR and interventional radiology in biliary atresia candidates for liver transplantation显示文摘The multi-detector computed tomography (MDCT) scan and magnetic resonance (MR) of the abdomen play a key role in the work-up to liver transplantation (LT) by identifying congenital anomalies or cirrhosis-related modifications, conditions that can require changes in surgical technique. Moreover, the MDCT and MR scans allow identification of cirrhotic liver hepatic masses, extrahepatic porto-systemic shunts, eventual thrombosis of portal system and radiological signs of portal hypertension associated with biliary atresia (BA). The aim of this paper is to review MDCT, MR imaging and interven-tional radiology procedures performed to evaluate morphological changes and degree of portal hypertension in pediatric patients with end-stage liver disease secondary to BA, who are candidates for LT. Advances in the field of MR, MDCT and in percutaneous minimally invasive techniques have increased the importance of radiology in the management of pediatric patients with BA who are candidates for LT. | Roberto Miraglia Settimo Caruso Luigi Maruzzelli Marco Spada Silvia Riva Marco Sciveres Angelo Luca | 2011 | World Journal of Radiology2011，3，9： | 2 |
| 8 | Percutaneous transarterial embolization of extrahepatic arteroportal fistula显示文摘Arteroportal fi stula is a rare cause of prehepatic portal hypertension. A 44-year-old male with hepatitis virus C infection was admitted for acute variceal bleeding. Endoscopy showed the presence of large esophageal varices. The ultrasound revealed a mass near the head of pancreas, which was characterized at the color- Doppler by a turbulent ? ow, and arterialization of portal vein ? ow. CT scan of abdomen showed a large aneurysm of the gastroduodenal artery communicating into the superior mesenteric vein. The sinusoidal portal pressure measured as hepatic vein pressure gradient was normal, confi rming the pre-hepatic origin of portal hypertension. The diagnosis of extrahepatic portal hypertension secondary to arteroportal fistula was established, and the percutaneous embolization was performed. Three months later, the endoscopy showed absence of esophageal varices and ascites. At the moment, the patient is in good clinical condition, without signs of portal hypertension. | Gianluca Marrone Settimo Caruso Roberto Miraglia Ilaria Tarantino Riccardo Volpes Angelo Luca | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 9 | Novel,highly potent aldose reductase inhibitors:cyano (2-oxo-2,3-dihydroindol-3-yl) acetic acid derivatives显示文摘 | DA SETTIMO F PRIMOFIORE G DA SETTIMO A | 2003 | J Med Chem2003，46，8： | 1 |
| 10 | Naphtho isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors显示文摘 | DA SETTIMO F PRIMOFIORE G LA MOTTA C | 2005 | J Med Chem2005，48，22： | 1 |
| 11 | Structural requirements to obtain highly potent and selective 18 kDa translocator protein(TSPO)ligands显示文摘 | Taliani S Pugliesi I Da Settimo F | 2011 | Curr Top Med Chem2011，11，7： | 1 |
| 12 | Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs 显示文摘 | Salerno S Da Settimo F Taliani S | 2010 | Curr Med Chem2010，17，35： | 1 |
| 13 | Novel,highly potent aldose reduetase inhibitors:cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives显示文摘 | Da Settimo F Pfimofiore G Da Settimo A | 2003 | J Med Chem2003，46，8： | 1 |
| 14 | Triazinobenzimidazole Acetic Acid Derivatives:A New Class of Selective AIdose Reductase Inhibitots显示文摘 | Da Settimo F Primofiore G Da Settimo A | 2001 | J Med Chem2001，44，25： | 1 |
| 15 | Transjugular liver biopsy in liver transplant patients using an 18-gauge automated core biopsy needle显示文摘 | Roberto Miraglia Luigi Maruzzelli Marta Ida Minervini Riccardo Volpes Giovanni Vizzini Salvatore Gruttadauria Settimo Caruso Angelo Luca Bruno Gridelli | 2010 | European Journal of Radiology2010，，3： | 1 |
| 16 | Natural Course of Extrahepatic Nonmalignant Partial Portal Vein Thrombosis in Patients with Cirrhosis显示文摘 | Angelo Luca Settimo Caruso Mariapina Milazzo Gianluca Marrone Giuseppe Mamone Francesca Crinò Luigi Maruzzelli Roberto Miraglia Gaetano Floridia Giovanni Vizzini | 2012 | Radiology2012，，1： | 1 |
| 17 | Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A(GABAA)alpha2 benzodiazepine receptor显示文摘 | Taliani S Cosimelli B Da Settimo F | 2009 | J Med Chem2009，52，12： | 1 |
| 18 | Multidetector-row computed tomography (MDCT) for the diagnosis of hepatocellular carcinoma in cirrhotic candidates for liver transplantation: prevalence of radiological vascular patterns and histological correlation with liver explants显示文摘 | Angelo Luca Settimo Caruso Mariapina Milazzo Giuseppe Mamone Gianluca Marrone Roberto Miraglia Luigi Maruzzelli Vincenzo Carollo Marta Ida Minervini Giovanni Vizzini Salvatore Grutttadauria Bruno Gridelli | 2010 | European Radiology2010，，4： | 1 |
| 19 | Multidetector computed tomography hepatic findings in children with end-stage biliary atresia显示文摘 | Settimo C Roberto M Mariapina M | | 0，，06： | 1 |
| 20 | Translocator protein ligands as promising therapeutic tools for anxiety disorders显示文摘 | Taliani S Da Settimo F Da Pozzo E | 2009 | Curr Med Chem2009，16，26： | 1 |
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