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| 1 | Efficacy of transcatheter embolization/chemoembolization (TAE/TACE) for the treatment of single hepatocellular carcinoma显示文摘AIM:To investigate the efficacy of transcatheter embolization/chemoembolization (TAE/TACE) in cirrhotic patients with single hepatocellular carcinoma (HCC) not suitable for surgical resection and percutaneous ablation therapy. METHODS:A cohort of 176 consecutive cirrhotic patients with single HCC undergoing TAE/TACE was reviewed; 162 patients had at least one image examination (helical CT scan or triphasic contrastenhanced MRI) after treatment and were included into the study. TAE was performed with Lipiodol followed by Gelfoam embolization; TACE was performed with Farmorubicin prepared in sterile drip at a dose of 50 mg/m2,infused over 30 min using a peristaltic pump,and followed by Lipiodol and Gelfoam embolization. RESULTS:Patients characteristics were:mean age,62 years; male/female 117/45; Child-Pugh score 6.2 ± 1.1; MELD 8.7 ± 2.3; mean HCC size,3.6 (range 1.0-12.0) cm. HCC size class was ≤ 2.0 cm,n = 51; 2.1-3.0 cm,n = 35; 3.1-4.0 cm,n = 29; 4.1-5.0 cm,n = 22; 5.1-6.0 cm,n = 11; and > 6.0 cm,n = 14. Patients received a total of 368 TAE/TACE (mean 2.4 ± 1.7). Complete tumor necrosis was obtained in 94 patients (58%),massive (90%-99%) necrosis in 16 patients (10%),partial (50%-89%) necrosis in 18 patients (11%) and poor (< 50%) necrosis in the remaining 34 patients (21%). The rate of complete necrosis according to the HCC size class was:69%,69%,52%,68%,50% and,13% for lesions of ≤ 2.0,2.1-3.0,3.1-4.0,4.1-5.0,5.1-6.0,and > 6.0 cm,respectively. Kaplan-Mayer survival at 24-mo was 88%,68%,59%,59%,45%,and 53% for lesions of ≤ 2.0,2.1-3.0,3.1-4.0,4.1-5.0,5.1-6.0,and > 6.0 cm,respectively. CONCLUSION:Our study showed that in cirrhotic patients with single HCC smaller than 6.0 cm,TAE/TACE produces complete local control of tumor in a significant proportion of patients. TAE/TACE is an effective therapeutic option in patients with single HCC not suitable for surgical resection or percutaneous ablation therapies. Further studies should investigate if the new available embolization agents or drug eluting beads may improve the effect on tumor necrosis. | Roberto Miraglia Giada Pietrosi Luigi Maruzzelli Ioannis Petridis Settimo Caruso Gianluca Marrone Giuseppe Mamone Giovanni Vizzini Angelo Luca Bruno Gridelli | 2007 | World Journal of Gastroenterology2007，13，21： | 38 |
| 2 | Interventional radiology procedures in adult patients who underwent liver transplantation显示文摘Interventional radiology has acquired a key role in every liver transplantation(LT)program by treating the majority of vascular and non-vascular post-transplant complications,improving graft and patient survival and avoiding,in the majority of cases,surgical revision and/or re-transplantation.The aim of this paper is to review indications,technical consideration,results achievable and potential complications of interventional radiology procedures after deceased donor LT and living related adult LT. | Roberto Miraglia Luigi Maruzzelli Settimo Caruso Mariapina Milazzo Gianluca Marrone Giuseppe Mamone Vincenzo Carollo Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 3 | Imaging in liver transplantation显示文摘The aim of this study was to illustrate the role of noninvasive imaging tools such as ultrasonography,multidetector row computed tomography,and magnetic resonance imaging in the evaluation of pediatric and adult liver recipients and potential liver donors,and in the detection of potential complications arising from liver transplantation. | Settimo Caruso Roberto Miraglia Luigi Maruzzelli Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 8 |
| 4 | MDCT, MR and interventional radiology in biliary atresia candidates for liver transplantation显示文摘The multi-detector computed tomography (MDCT) scan and magnetic resonance (MR) of the abdomen play a key role in the work-up to liver transplantation (LT) by identifying congenital anomalies or cirrhosis-related modifications, conditions that can require changes in surgical technique. Moreover, the MDCT and MR scans allow identification of cirrhotic liver hepatic masses, extrahepatic porto-systemic shunts, eventual thrombosis of portal system and radiological signs of portal hypertension associated with biliary atresia (BA). The aim of this paper is to review MDCT, MR imaging and interven-tional radiology procedures performed to evaluate morphological changes and degree of portal hypertension in pediatric patients with end-stage liver disease secondary to BA, who are candidates for LT. Advances in the field of MR, MDCT and in percutaneous minimally invasive techniques have increased the importance of radiology in the management of pediatric patients with BA who are candidates for LT. | Roberto Miraglia Settimo Caruso Luigi Maruzzelli Marco Spada Silvia Riva Marco Sciveres Angelo Luca | 2011 | World Journal of Radiology2011，3，9： | 2 |
| 5 | Liver regeneration after liver resection: Clinical aspects and correlation with infective complications显示文摘AIM:To investigate whether early liver regeneration after resection in patients with hepatic tumors might be influenced by post-operative infective complications.METHODS:A retrospective analysis of 27 liver resections for tumors performed in a single referral center from November 2004 to January 2010.Regeneration was evaluated by multidetector computed tomographyat a mean follow-up of 43.85 d.The Clavien-Dindo classification was used to evaluate postoperative events in the first 6 mo after transplantation,and Centers for Disease Control and Prevention definitions were used for healthcare associated infections data.Generalized linear regression models with Gaussian family distribution and log link function were used to reveal the principal promoters of early liver regeneration.RESULTS:Ten of the 27 patients(37%)underwent chemotherapy prior to surgery,with a statistically significant prevalence of patients with metastasis(P=0.007).Eight patients(30%)underwent embolization,3 with primary tumors,and 5 with secondary tumors.Twenty patients(74%)experienced complications,with 12(60%)experiencing Clavien-Dindo Grade 3a to 5 complications.Regeneration≥100%occurred in 10(37%)patients.The predictors were smaller future remnant liver volume(-0.002;P<0.001),and a greater spleen volume/future remnant liver volume ratio(0.499;P=0.01).Patients with a resection of≥5 Couinaud segments experienced greater early regeneration(P=0.04).Nine patients experienced surgical site infections,and in 7 cases Clavien-Dindo Grade 3a to 4 complications were detected(P=0.016).There were no significant differences between patients with primary or secondary tumors,and either onset or infections or severity of surgical complications.CONCLUSION:Regardless of the onset of infective complications,future remnant liver and spleen volumes may be reliable predictors of early liver regeneration after hepatic resection on an otherwise healthy liver. | Duilio Pagano Marco Spada Vishal Parikh Fabio Tuzzolino Davide Cintorino Luigi Maruzzelli Giovanni Vizzini Angelo Luca Alessandra Mularoni Paolo Grossi Bruno Gridelli Salvatore Gruttadauria | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 6 | A case of biliary stones and anastomotic biliary stricture after liver transplant treated with the rendez-vous technique and electrokinetic lithotritor显示文摘The paper studies the combined radiologic and endoscopic approach (rendez vous technique) to the treatment of the biliary complications following liver transplant. The 'rendez-vous' technique was used with an electrokinetic lithotripter, in the treatment of a biliary anastomotic stricture with multiple biliary stones in a patient who underwent orthotopic liver transplant. In this patient, endoscopic or percutaneous transhepatic management of the biliary complication failed. The combined approach, percutaneous transhepatic and endoscopic treatment (rendez-vous technique) with the use of an electrokinetic lithotritor, was used to solve the biliary stenosis and to remove the stones. Technical success, defined as disappearance of the biliary stenosis and stone removal, was obtained in just one session, which definitively solved the complications. The combined approach of percutaneous transhepatic and endoscopic (rendez-vous technique) treatment, in association with an electrokinetic lithotritor, is a safe and feasible alternative treatment, especially after the failure of endoscopic and/or percutaneous trans-hepatic isolated procedures. | Marta Di Pisa Mario Traina Roberto Miraglia Luigi Maruzzelli Riccardo Volpes Salvatore Piazza Angelo Luca Bruno Gridelli | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 7 | Transjugular liver biopsy in liver transplant patients using an 18-gauge automated core biopsy needle显示文摘 | Roberto Miraglia Luigi Maruzzelli Marta Ida Minervini Riccardo Volpes Giovanni Vizzini Salvatore Gruttadauria Settimo Caruso Angelo Luca Bruno Gridelli | 2010 | European Journal of Radiology2010，，3： | 1 |
| 8 | Natural Course of Extrahepatic Nonmalignant Partial Portal Vein Thrombosis in Patients with Cirrhosis显示文摘 | Angelo Luca Settimo Caruso Mariapina Milazzo Gianluca Marrone Giuseppe Mamone Francesca Crinò Luigi Maruzzelli Roberto Miraglia Gaetano Floridia Giovanni Vizzini | 2012 | Radiology2012，，1： | 1 |
| 9 | Multidetector-row computed tomography (MDCT) for the diagnosis of hepatocellular carcinoma in cirrhotic candidates for liver transplantation: prevalence of radiological vascular patterns and histological correlation with liver explants显示文摘 | Angelo Luca Settimo Caruso Mariapina Milazzo Giuseppe Mamone Gianluca Marrone Roberto Miraglia Luigi Maruzzelli Vincenzo Carollo Marta Ida Minervini Giovanni Vizzini Salvatore Grutttadauria Bruno Gridelli | 2010 | European Radiology2010，，4： | 1 |
| 10 | Usefulness of the “Rendezvous” Technique in Living Related Right Liver Donors with Postoperative Biliary Leakage from Bile Duct Anastomosis显示文摘 | R. Miraglia M. Traina L. Maruzzelli S. Caruso M. Di Pisa S. Gruttadauria A. Luca B. Gridelli | 2008 | CardioVascular and Interventional Radiology2008，，5： | 1 |
| 11 | Predictive Factors of Downstaging of Hepatocellular Carcinoma Beyond the Milan Criteria Treated with Intra-arterial Therapies显示文摘 | Valentina Bova Roberto Miraglia Luigi Maruzzelli Giovanni Battista Vizzini Angelo Luca | 2013 | CardioVascular and Interventional Radiology2013，，2： | 1 |
| 12 | ComParison between radia- tion exposure levels using an image intensifier and a flat-Panel detector- based system in image-guided central venous catheter Place- ment in children weighing less than 10 kg显示文摘 | Miraglia R Maruzzelli L Cortis K | 2015 | Pediatr Radiol2015，45，2： | 1 |
| 13 | Usefulness of the “Rendezvous” Technique in Living Related Right Liver Donors with Postoperative Biliary Leakage from Bile Duct Anastomosis显示文摘 | R. Miraglia M. Traina L. Maruzzelli S. Caruso M. Di Pisa S. Gruttadauria A. Luca B. Gridelli | 2008 | CardioVascular and Interventional Radiology2008，，5： | 1 |
| 14 | Recanalization of occlusive transjugular intrahepatic portosystemic shunts inac- cessible to the standard transvenous approach 显示文摘 | MIRAGLIA R MARUZZELLI L LUCA A | 2013 | Diagn In- terv Radiol2013，19，1： | 1 |
| 15 | Biliary wall calcification in Langerhans cell histiocytosis:report of two cases显示文摘 | Caruso S Miraglia R Maruzzelli L Luca A Gridelli B | | 0，，07： | 1 |
| 16 | Transjugular liver biopsy in liver transplant patients using an 18-gauge automated core biopsy needle显示文摘 | Roberto Miraglia Luigi Maruzzelli Marta Ida Minervini Riccardo Volpes Giovanni Vizzini Salvatore Gruttadauria Settimo Caruso Angelo Luca Bruno Gridelli | 2010 | European Journal of Radiology2010，，3： | 1 |
| 17 | Predictive factors of tumor response to trans-catheter treatment in cirrhotic patients with hepatocellular carcinoma:A multivariate analysis of pre-treatment findings显示文摘AIM: To elucidate the pre-treatment clinical and imaging findings affecting the tumor response to the transcatheter treatment of unresectable hepatocellular carcinoma (HCC). METHODS: Two hundred cirrhotic patients with HCC received a total of 425 transcatheter treatments. The tumor response was evaluated by helical CT and a massive necrosis (MN) was def ined as a necrosis > 90%. Twenty-f ive clinical and imaging variables were analyzed: uninodular/multinodular HCC, unilobar/bilobar, tumor capsula, hypervascular lesion, portal vein thrombosis, portal hypertension, ascites, platelets count, aspartate transaminases/alanine transaminases (AST/ALT), alfa- fetoprotein (AFP) > 100, AFP > 400, serum creatinine, virus hepatitis C (VHC) cirrhosis, performance status, age, Okuda stage, Child-Pugg stage, sex, CLIP (Cancer of the Liver Italian Program) score, serum bilirubin, constitutional syndrome, serum albumine, prothrombin activity, BCLC (Barcelona Clinic Liver Cancer) stage. Prognostic factors of response were subjected to univariate analysis and thereafter, when significant, to the multivariate analyses. RESULTS: On imaging analysis, complete response wasobtained in 60 (30%) patients, necrosis > 90% in 38 (19%) patients, necrosis > 50% in 44 (22%) patients, and necrosis < 50% in 58 (29%) patients. Ninety-eight (49%) of the 200 patients were considered to have a MN. In univariate analysis, significant variables (P < 0.01) were: uninodular tumor, unilobar, tumor size 2-6 cm, CLIP score < 2, absence of constitutional syndrome, and BCLC stage < 2. In a multivariate analysis, the variables reaching statistical signifi cance were: presence of tumor capsule (P < 0.0001), tumor size 2-6 cm (P < 0.03), CLIP score < 2 (P < 0.006), and absence of constitutional syndrome (P < 0.03). Kaplan-Mayer cumulative survival at 12 mo was 80% at 24 mo was 56%. MN was associated with a longer survival (P < 0.0001). CONCLUSION: MN after transcatheter treatment is more common in the presence of tumor capsule, maximum diameter of the main lesion between 2 and 6 cm, CLIP score < 2 and absence of constitutional syndrome. The ability to predict which patients will respond to transcatheter treatment may be useful in the clinical decision-making process, and in stratifying the randomization of patients in clinical trials. | Roberto Miraglia Giada Pietrosi Luigi Maruzzelli Ioannis Petridis Settimo Caruso Gianluca Marrone Giuseppe Mamone Giovanni Vizzini Angelo Luca Bruno Gridelli | 2007 | World Journal of Gastroenterology2007，13，45： | 1 |
| 18 | Nkx2-5(+) isletl(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity显示文摘 | Castagnaro L Lenti E Maruzzelli S | 2013 | Immunity2013，38，4： | 1 |
| 19 | Natural Course of Extrahepatic Nonmalignant Partial Portal Vein Thrombosis in Patients with Cirrhosis显示文摘 | Angelo Luca Settimo Caruso Mariapina Milazzo Gianluca Marrone Giuseppe Mamone Francesca Crinò Luigi Maruzzelli Roberto Miraglia Gaetano Floridia Giovanni Vizzini | 2012 | Radiology2012，，1： | 1 |
| 20 | An unusual presentation of malignant hepatic epithelioid haemangioendothelioma with left pleural and pulmonary localization显示文摘 | CARUSO S MIRAGLIA R MARUZZELLI L | 2008 | Pediatr Radiol2008，38，9： | 1 |
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