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| 1 | 对我国“体育产业”与“产业化”10年的反思和评价显示文摘我国提倡和推行“体育产业”和“产业化”的 10年来 ,取得了成绩 ,也存在着迷误。现在 ,我们需要与时俱进。对 10年的发展认真反思 ,推陈出新 ,使认识跃上一个新境界 ,在新世纪开创体育发展的新局面。 | 韩丹 HANDan | 2003 | 体育与科学2003，24，1： | 30 |
| 2 | Maastricht Ⅱ treatment scheme and efficacy of different proton pump inhibitors in eradicating Helicobacter pylori显示文摘AIM: The Maastricht Ⅱ criteria suggest the use of amoxicillin and clarithromycin in addition to a proton pump inhibitor over 7-10 d as a first line therapy in the eradication of Helicobacter pylori (Hpylori). For each proton pump inhibitor, various rates of eradication have been reported. The present study was to compare the efficacy of different proton pump inhibitors like omeprazole, lansoprazole and pantoprazole in combination with amoxicillin and clarithromycin in the first line eradication of Hpylonand to investigate the success of H pylonrieradication in our district. METHODS: A total of 139 patients were included having a Helicobacter pylori (+) gastroduodenal disorders diagnosed by means of histology and urease test. Besides amoxicillin (1000 mg twice a day) and darithromycin (500 mg twice a day), they were randomized to take omeprazole (20 mg twice a day), or lansoprazole (30 mg twice a day), or pantoprozole (40 mg twice a day) for 14 d. Four weeks after the therapy, the eradication was assessed by means of histology and urease test. It was evaluated as eradicated if the Hpyloriwas found negative in both. The complaints (pain in epigastrium, nocturnal pain, pyrosis and bloating) were graded in accordance with the Licert scale. The compliance of the patients was recorded. RESULTS: The eradication was found to be 40.8% in the omeprazole group, 43.5% in the lansoprazole group and 47.4% in the pantoprazole group. Sixty-three out of 139 patients (45%) had eradication. No statistically significant difference was observed between the groups. Significant improvements were seen in terms of the impact on the symptom scores in each group. CONCLUSION: There was no difference between omeprazole, lansoprazole and pantoprazole in H pylori eradication, and the rate of eradication was as low as 45%. Symptoms were improved independent of the eradication in each treatment group. The low eradication rates suggest that the antibiotic resistance or the genetic differences of the microorganism might be in effect. Further studies are required to verify these suggestions. | EnginAltintas OrhanSezgin Oguz Ulu Ozlem Avdin Handan Camdeviren | 2004 | World Journal of Gastroenterology2004，10，11： | 23 |
| 3 | 河北省永年县何庄遗址发掘报告显示文摘何庄遗址位于河北省永年县临沼关西南约15公里的何庄北,北临通天河,西面是起伏的丘陵地带,东面约1公里处为北两岗水库(图一)。何庄遗址是1987年永年县文物保管所在文物普查中发现的,面积约3万平方米。由于当地农民烧砖取土,对遗址的破坏非常严重,因此,1988年8月9日至9月12日,邯郸地区文物保管所和永年县文物保管所联合对该遗址进行了抢救性发掘,开挖5×5米探方13个,面积325平方米。 | Handan Prefectural Office for the Preservation of Ancient Monuments and Yongnian County Office for the Preservation of Ancient Monuments, | 1992 | 华夏考古1992，，4： | 21 |
| 4 | C-reactive protein,procalcitonin,interleukin-6,vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric cancer显示文摘The current study was to determine the serum/plasmalevels of VEGF, IL-6, malondialdehyde (MDA), nitric oxide(NO), PCT and CRP in gastric carcinoma and correlation withthe stages of the disease and accompanying infection. | NevinIlhan NecipIlhan MehmetKcksu Yavuz Ilhan Handan Akbulut | 2004 | World Journal of Gastroenterology2004，10，8： | 18 |
| 5 | Identification on threshold and efficiency of rainfall replenishment to soil water in semi-arid loess hilly areas显示文摘As one critical source of water for maintaining ecosystems in arid and semi-arid regions, rainfall replenishment to soil water can determine vegetation growth and ecosystem functions. However, the limited rainfall resources were often not used effectively in the semi-arid loess hilly areas due to random temporal and spatial distribution of rainfall and specific vegetation features. Thus, it is highly significant to determine the threshold and efficiency of rainfall replenishment to soil water under different vegetation types. The threshold and efficiency can offer scientific evidence for rehabilitating vegetation and improving efficiency of using rainfall resources. In this study, the efficiency and threshold of rainfall replenishment to soil water were determined under natural grassland, wheat, artificial grassland, sea buckthorn shrubland and Chinese pine forestland based on consecutive measurements. The results indicated that the lag-time, rate, efficiency of rainfall replenishment to soil water were closely related to vegetation type, with significant differences existing among different vegetation types. The lag-time for natural grassland in the soil horizon of 20 cm was the shortest one(26.4 h), followed by wheat(27.8 h), sea buckthorn(41.8 h), artificial grassland(50.0 h) and Chinese pine(81.8 h).The value of replenishment rate, followed the order of wheat(0.40 mm h^(-1))> natural grassland(0.30 mm h(-1))> sea buckthorn(0.17 mm h(-1))> artificial grassland(0.14 mm h(-1))> Chinese pine(0.09 mm h(-1)). As for the efficiency of rainfall replenishment to soil water, natural grassland was the most efficient one(35.1%), followed by wheat(29.2%), sea buckthorn(16.8%), artificial grassland(11.5%), Chinese pine(4.2%). At last, it was found that wheat had the lowest threshold(6.8 mm) of rainfall replenishment to soil water, which was followed by natural grassland(10.5 mm), sea buckthorn(20.5 mm), artificial grassland(22.6 mm) and Chinese pine(26.4 mm). These results implied that soil water in natural grassland was sensitive to rainfall and easily to be replenished, while soil water in Chinese pine was harder to be replenished by rainfall compared to other vegetation types. | Lei YANG Handan ZHANG Liding CHEN | 2018 | Science China Earth Sciences2018，61，3： | 17 |
| 6 | Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies显示文摘Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient β-globin synthesis leading to β-thalassemia.These two major forms of β-hemoglobinopathies cause impaired erythropoiesis and life-threatening anemia.Clinical evidence has suggested that reaaivation of fetal γ-globin(HBG)gene expression which is normally silenced after birth by certain genetic mutations can ameliorate the clinical course of β-hemoglobinopathies. | Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li | 2020 | Cell Research2020，30，3： | 14 |
| 7 | Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure显示文摘AIM: To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure (CRF).METHODS: Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori (H pylori) and CRF status. Groups were labeled as follows: 1a: normal renal function, H pylori negative (n = 12), 1b: normal renal function,H pylori positive (n = 11), 2a: CRF, H pylori negative (n = 10), 2b: CRF, H pylori positive (n = 11). Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation,antral biopsy specimens were taken from each patient.In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen (PCNA) labeling indexes (LI) were assessed with immunohistochemical staining method.RESULTS: For groups 1a, 1b, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5,60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22,respectively. When the one-way ANOVA test was applied,statistically significant differences were detected between the groups for both Bax LI (P = 0.004 <0.01) and PCNA LI (P = 0.009 <0.01). When groups were compared further in terms of Bax LI and PCNA LI with Tukey's HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups 1a and 2b (P = 0.006 <0.01).CONCLUSION: In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells. | Selim Aydemir Binnaz Handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 8 | Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis显示文摘瞄准:为了调查外长的 erythro-poietin (EPO ) 的效果,在钠 taurodeoxycholate- 的一个试验性的模型的尖锐的肺损害(ALI ) 上的管理导致了尖锐引起坏死胰腺炎(ANP ) 。方法:47 只男 Wistar 白鼠随机被划分成 7 个组:假冒的组(n = 5 ) , 3 个 ANP 组(n = 7 各个) 并且 3 个 EPO 组(n = 7 各个) 。ANP 被导致由后退进胆总管的 5% 钠 taurodeoxycholate 的注入。在 EPO 组的老鼠收到了 1000 U/kg 肌内的 EPO 立即在 ANP 的正式就职以后。在 ANP 组的老鼠相反被给 1 mL 生理盐水。所有动物被牺牲在手术后 24 h, 48 h 和 72 h。浆液 amilase, IL-2, IL-6 和肺织物 malondialdehyde (MDA ) 被测量。胸膜渗漏体积和肺 / 身体重量(LW/BW ) 比率是计算的。TNF-alpha, IL-2 和 IL-6 的织物层次组织化学地是屏蔽免疫。另外, ox-LDL 累积与免疫者荧光灯的染色被估计。在肺的组织病理学说的改变也被获得。结果:吝啬的胸膜渗漏体积,计算 LW/BW 比率,浆液 IL-6 和肺织物 MDA 层次比在 ANP 组在 EPO 组是显著地更低的。不,统计上,有效差量在这些组之中在浆液或 IL-2 的织物价值被观察。当时, ox-LDL 的肿瘤坏死 factor-alpha (TNF-alpha ) 和 IL-6 和累积的水平在 ANP 组的肺纸巾是明显的与 EPO 组相比,特别地在 72 h。组织病理学说的评估在外长的 EPO 管理以后在肺损害参数证实了改进,特别地在 48 h 和 72 h。结论:EPO 管理由禁止 polymorphonuclear (PMNL ) 在 ALI 参数导致重要减少累积,减少专业版的层次在每氧化的循环,保存微脉管的内皮房间正直和减少的氧化联系压力的类脂化合物的煽动性的 cytokines 并且因此,能在导致 ANP 的 ALI 被认为是一个 cytoprotective 代理人。 | Oge Tascilar Güldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan Burak Bahadir Serefden Acikgoz Oktay Irkorucu Kemal Karakaya Hakan Balbaloglu Gürkan Kertis Handan Ankarali Mustafa Comert | 2007 | World Journal of Gastroenterology2007，13，46： | 8 |
| 9 | Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death显示文摘 | Lifeng Yuan Linhui Zhai Lili Qian De Huang Yi Ding Handan Xiang Xiaojing Liu J. Will Thompson Juan Liu Yong-Han He Xiao-Qiong Chen Jing Hu Qing-Peng Kong Minjia Tan Xiao-Fan Wang | 2018 | Cell Research2018，28，6： | 7 |
| 10 | Regional homogeneity abnormalities in patients with tensiontype headache:a resting-state fMRI study显示文摘Tension-type headache(TTH) is the most prevalent type of primary headache. Many studies have shown that the pathogenesis of primary headache is associated with fine structural or functional changes. However, these studies were mainly based on migraine. The present study aimed to investigate whether TTH patients show functional disturbances compared with healthy subjects. We used restingstate functional magnetic resonance imaging(f MRI) and regional homogeneity(Re Ho) analysis to identify changes in the local synchronization of spontaneous activity in patients with TTH. Ten patients with TTH and 10 age-, gender-, and education-matched healthy controls participated in the study. After demographic and clinical characteristics were acquired, a 3.0-T MRI system was used to obtain restingstate f MRIs. Compared with healthy controls, the TTH group exhibited significantly lower Re Ho values in the bilateral caudate nucleus, the precuneus, the putamen, the left middle frontal gyrus, and the superior frontal gyrus. There was no correlation between mean Re Ho values in TTH patients and duration of TTH, number of attacks, duration of daily attacks, Visual Analogue Scale score, or Headache Impact Test-6 score. These results suggest that TTHpatients exhibit reduced synchronization of neuronal activity in multiple regions involved in the integration and processing of pain signals. | Pian Wang Handan Du Ning Chen Jian Guo Qiyong Gong Junran Zhang Li He | 2014 | Neuroscience Bulletin2014，30，6： | 6 |
| 11 | Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion显示文摘AIM: To evaluate central macular thickness(CMT) and mean choroidal thickness(MCT) in eyes with branch retinal vein occlusion(BRVO), before and after ranibizumab treatment using spectral domain-optical coherence tomography(SD-OCT).·METHODS: Forty-two patients with unilateral BRVO and macular edema were included in this study. There were 25 men and 17 women. Using SD-OCT, choroidal thickness was measured at 500 μm intervals up to 1500μm temporal and nasal to the fovea. MCT was calculated based on the average of the 7 locations. All the eyes with BRVO were treated with intravitreal ranibizumab(0.5 mg/0.05 m L). Comparisons between the BRVO and fellow eyes were analyzed using Mann-Whitney U test. Preinjection and post-injection measurements were analyzed using Wilcoxon test and repeated measure analysis.· RESULTS: At baseline, there was a significant difference between the BRVO and fellow eyes in MCT[BRVO eyes 245(165-330) μm, fellow eyes 229(157-327) μm]and CMT [BRVO eyes 463(266-899) μm, fellow eyes 235(148-378) μm(P =0.041, 0.0001, respectively)]. Following treatment, CMT [295(141-558) μm] and MCT [229(157-329) μm] decreased significantly compared to the baseline measurements(P =0.001, 0.006, respectively).Also BCVA(log MAR) improved significantly(P=0.0001) in the BRVO eyes following treatment. After treatment CMT[BRVO eyes 295(141-558) μm, fellow eyes 234(157-351) μm]and MCT [BRVO eyes 229(157-329) μm, fellow eyes 233(162-286) μm] values did not reveal any significant difference in BRVO eyes and fellow eyes(P=0.051, 0.824,respectively).· CONCLUSION: In eyes with BRVO, CMT and MCT values are greater than the fellow eyes, and decrease significantly following ranibizumab injection. | Muge Coban-Karatas Rana Altan-Yaycioglu Burak Ulas Selcuk Sizmaz Handan Canan Cagla Sariturk | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 6 |
| 12 | Review of the monograph Mathematical Treatment and Application of Uncertain Information显示文摘The present age is an informational one. Treating the information has become an important step for people to make quantitative analysis in ordinary life, production, scientific study, etc. People have already obtained rich experience and knowledge about treating certain information. And this is just called classical mathematics. In order to represent and treat uncertain information (random information, fuzzy information, grey information and unascertained information), uncertain mathematics has appeared correspondingly (probability statistics, fuzzy math ematics, grey mathematics and unascertained mathematics). Probability statistics[1], fuzzy mathematic[2], grey mathematics[3] and unascertained mathematics[4] are | YANG ZhiminHandan Teachers College, Handan 056004, China | 2001 | Chinese Science Bulletin2001，46，7： | 6 |
| 13 | Applied Sequence Stratigraphy in Nonmarine Basin of China显示文摘This paper presents a preliminary summary of the applied sequence stratigraphy in nonmarine basins in China. The geological and geophysical data show that the nonmarine sequences mainly resulted from both allocyclic and autocyclic processes where the most important factors were isolated tectonics and climate. However, the environmental factor should have been crucial. The depositional base level served as the sea level in the marine environment, while the water table, lake level and fluvial equilibrium were profiled in a terrigenous environment. This accommodation varied periodically with the base level, resulting in the formation of a series of depositional sequences in terms of genesis and space. Basically, the base level of the inner continent was not affected by the changes in the relative sea level. But there would have been some relations between the changes in the relative sea level and that in the continental base level during eustacy flooding. However, a small time lag existed between the changes in the marine basin and the inner continent basin, The lake basin is smaller than the marine basin, but its velocity of sediment supply is greater than that of the marine basin. Therefore, the number of nonmarine sequences is greater than that of marine ones in the same period. It is important to recognize the system tracts for the study of high-precision or high-resolution sequence stratigraphy, especially to analyze the low-stand systems tract with its depositional system. The sequence boundary is genetically characterized by subaerial exposure, stratigraphic truncation and subaqueous erosion. The deposition analysis of Zhanhua depression reveals 5 sequence architectures: alluvial-fluvial/lacustrine architecture, transitional architecture formed between haline (mesohaline) lake and fresh lake, marine duration-deep lacustrine architecture, half deep lacustrine-ramp architecture and fluvial-alluvial plain architecture. During the major development of the nonmarine basin, the step-faulting breaks controlled the depositional system. Usually, the low-stand complex fan, prograding wedge and high-stand turbidity fan were close to the third stepping break. In the low-stand period, the sediments went around the incised valleys which then were filled with sand bar near the second stepping break. At the first stepping break the sediments were bypassed step by step or the alluvial fan was deposited with forced regressions in the low-stand time. The low-stand wedge may serve as favorable subtle or complex traps at the basin floor fan. The economic effectiveness is measured with the borehole in Bohai Bay basin. | Wei Kuisheng Li Daliang Zhang Shoupeng Hao Yunqing Department of Energy and Geology , China University of Geosciences , Beijing 100083 Du Zhenchuan Department of Energy Resomces and Geology , Hebei Technology University , Handan 056038 Zong Guoho | 2001 | Journal of China University of Geosciences2001，12，4： | 5 |
| 14 | Ocular Trauma in a Rural Population of North China:The Handan Eye Study显示文摘Objective To determine the prevalence of ocular trauma and the proportion of blindness and visual impairment due to trauma in a rural population in northern China. Methods The Handan Eye Study is a population-based cross-sectional study that surveyed 6830 Chinese people aged 30+ years from 13 randomly selected villages in Yongnian County, city of Handan, Hebei Province, in July, 2006. All participants underwent a standardized interview and extensive examinations. A structured questionnaire was used to collect information on ocular trauma. Results Of the 5837 participants who filled out the questionnaire, 124 subjects [2.1%; 95% confidence interval(CI), 1.8%-2.5%] reported a history of ocular trauma in either eye, including 19(0.3%) persons reporting trauma in both eyes. Men were more likely to have an eye injury than women [odds ratio(OR), 3.3; 2.2-4.9]. In multiple logistic regression models, ocular trauma was significantly more frequent among normotensive participants when compared with hypertensive participants(hypertensive vs. normotensive: OR, 0.6; 0.4-0.9) and among participants who had a history of falls(OR, 2.4; 1.2-4.8). The proportion of unilateral visual impairment and unilateral blindness due to trauma were 10.5%(13 subjects) and 21.0%(26 subjects), respectively. Conclusion Our study reports the prevalence of severe ocular trauma among adults in rural China, revealing a high proportion of blindness and visual impairment due to trauma. These findings suggest the need for educational strategies to increase eye health awareness in this rural population with focus on providing at least appropriate first aid care to reduce blindness due to trauma. | ZHOU Jun WANG Feng Hua LU Hai LIANG Yuan Bo WANG Ning Li the Handan Eye Study Group | 2015 | Biomedical and Environmental Sciences2015，28，7： | 4 |
| 15 | EGF promotes mammalian cell growth by suppressing cellular senescence显示文摘 | Peter B Alexander Lifeng Yuan Pengyuan Yang Tao Sun Rui Chen Handan Xiang Jiekai Chen Haoyu Wu Daniel R Radiloff Xiao-Fan Wang | 2015 | Cell Research2015，25，1： | 3 |
| 16 | Effect of herb-partitioned moxibustion on dopamine levels and dopamine receptor 1 expression in the colon and central nervous system in rats with Crohn’s disease显示文摘OBJECTIVE:To observe the effect of herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints in rats with Crohn's disease,and explore the underlying mechanism from dopamine (DA) and dopamine receptor 1 (D1 R) in the colon,spinal dorsal horn and hypothalamus.METHODS:The rats were randomly divided into the normal,model (CD),herb-partitioned moxibustion (Mox) and mesalazine (Mesa) groups.Damage in the colons was scored and observed by hematoxylin and eosin staining.DA and D1R protein expression in the colonic mucosa were detected by immunohistochemistry.The concentrations of DA and D1R in the spinal dorsal horn and hypothalamus were measured by enzyme-linked immunosorbent assay,and D1R mRNA expression was evaluated by quantitative real-time polymerase chain reaction.RESULTS:In the colon,compared with the normal group,DA,D1 R protein expressions and D1 R mRNA expression were significantly higher in the model group,while decreased in the Mox group and the Mesa group.In the spinal dorsal horn and hypothalamus,compared with the normal group,the concentrations of DA and D1 R,and the D1R mRNA expressions were significantly higher in the model group,and decreased in the Mox group and the Mesa group.CONCLUSION:Herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints relieved ulceration in CD rats,the underlying mechanism maybe relative with the regulation of DA and D1R in the colon,spinal dorsal horn and hypothalamus by moxibustion. | Lu Yuan Zheng Handan Lü Tingting Ma Zhe Wu Huangan Xu Manwen Weng Zhijun Feng Hui Zhang Fang Ding Guanghong Wu Luyi Liu Huirong | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 3 |
| 17 | EFFECT OF CATHODIC PROTECTION ON FRACTURE BEHAVIOUR OF LOWALLOY STEELS IN SEAWATER显示文摘Fracture behaviour of low-alloy steels AIST4340,HY100,Welten60,AISIA537 and A131 inartificial seawater under static,cyclic loading and at cathodic protection potential has beeninvestigated by using the techniques of fracture mechanics, electrochemistry andelectronfractography.The results reveal that at hydrogen evolution potentials(cathodic pro-tection potential)the critical yield strength required for the occurrance of SCC decreasesfrom 985 at corrosion potential(Ec)to 872 MPa.The effect of cathodic protection on crackpropagation of corrosion fatigue(CF)is not simple,it is closely related to the yield strengthof steels and their SCC behaviour.For the steels with high yield strength,cathodic protectionpromotes(da/dN)Ⅱ evidently,and reduces △Kth value.The(da/dN)-△K curves dis-play a plateau at the third stage of CF for steels with medium or low yield strength.It is men-tioned that the cathodic protection potential for oceaneering constructures should be control-led at top level of the protective range.It seems reasonable that the strength of steel foroceaneeing use might be increased by 200 or 300 MPa. | ZHENG Wenlong ZHU Xiying SU Limin Shanghai Research Institute of Materials,Shanghai,China ZHENG Wenlong,Senior Research Engineer,Shanghai Research Institute of Materials,99 Handan Road,Shanghai,China | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，1： | 2 |
| 18 | Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates显示文摘AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication. | Rana Altan-Yaycioglu Nedime Sahinoglu-Keskek Handan Canan Muge Coban-Karatas Burak Ulas | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 2 |
| 19 | 共济失调-毛细血管扩张症致病基因RNA干扰对胶质瘤细胞放射敏感性的影响显示文摘目的:观察共济失调毛细血管扩张症致病基因(ATM基因)的RNA干扰对胶质瘤细胞放射敏感性的影响。方法:选择ATM基因不同区域的DNA序列合成并纯化寡核苷酸后转染人胚胎肾脏细胞HEK293,根据对ATM蛋白不同的阻断效应,筛选用于制备ATM发夹结构shorthairpinstructure(shRNA)基因的最佳序列。将有效序列克隆入pSilencer1.0U6载体中,构建出shRNA的表达质粒并转染恶性胶质瘤细胞系U87细胞。以U87细胞为对照,应用Westernblot检测细胞中ATM基因的表达;以细胞存活分数(SF)来评估放射敏感性。结果:Westernblot显示shRNA介导的ATM基因沉默能明显阻断U87细胞中的ATM蛋白;与U87细胞相比,U87shRNA细胞SF明显降低,P<0.05。结论:由ATMshRNA构建的表达质粒能明显抑制ATM表达,增加胶质瘤细胞的放射敏感性。 | 关方霞 黄惠芳 杨波 GuhaC handan 奚彪 | 2006 | 郑州大学学报(医学版)2006，41，3： | 2 |
| 20 | 河北磁县境内牤牛河两岸考古调查显示文摘牤牛河发源于太行山南段东侧的峰峰矿区一带,由西向东,从林坦村进入磁县北部,向东汇入南北流向的滏阳河,全长约15公里。其上游河床狭窄,两岸为起伏的丘陵地带,直到袁庄村附近,河床骤然拓宽,以至林峰村西,形成扇面冲积平原,两岸台地平坦。1989年初,为配合河北省查遗补漏的文物复查工作,由邯郸地区文物保管所组成文物普查小组,对牤牛河两岸进行了专题性考古调查。参加调查的人员有张沅、王立军、翟中华、乔文学。调查于2月27日开始,至3月8日结束,历时10天。 | Handan Prefectural Institution for the Preservation of Anciet Monuments | 1993 | 华夏考古1993，，2： | 2 |
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