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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Predictability of outcome of caustic ingestion by esophagogastroduodenoscopy in children显示文摘AIM: To assess the necessity of esophagogastroduodenoscopy (EGD) to predict the outcome of caustic ingestion in children. METHODS: The study included 206 children who underwent EGD because of ingestion of caustic substances between January 2005 and August 2010. Retrospective analysis of data of the patients was performed. RESULTS: The male/female ratio was 1.6 and mean age was 38.1 ± 28.8 mo. The caustic substances were acidic in 72 (34.9%) cases, alkaline in 56 (27.2%), liquid household bleach in 62 (30.1%), and unknown in 16 (7.8%). Fifty-seven (27.7%) patients were symptom-free. Significant clinical findings were observed in 149 (72.3%) patients. Upper gastrointestinal endoscopy findings of esophageal injury were grade 0 in 86 (41.7%) patients, grade 1 in 49 (23.8%), grade 2a in 42 (20.4%), grade 2b in 28 (13.6%), and grade 3a in 1 (0.5%) patient. 35 patients with grade 2a, 2b, and 3a injuries underwent esophageal dilation at second week of ingestion. Esophageal stricture, which necessitated a regular dilation program developed in 13 of the aforementioned 35 patients. There is no statistically significant difference in the rate of development of esophageal stricture between the patients who ingested acidic (15.3%) and alkaline (8.9%) substances (P = 0.32). Severe gastric injury was detected in 38 (18.5%) patients. The rate of development of gastric injury was significantly higher in the acidic group (14%) than in the alkaline group (2.9%) (P = 0.001). Out of 149 patients with clinical findings, 49 (32.9%) patients had no esophageal injury and 117 (78.5%) patients had no gastric lesion. Esophageal and severe gastric injuries were detected in 20 (35.1%) and 8 (14%) of patients with no clinical findings respectively. Pyloric stenosis developed in 6 patients. Pyloric obstruction improved with balloon dilation in 2 patients. Mean hospitalization time were 1.2 ± 0.5 d for grade 0 and 2.3 ± 5 d for grade 1 and 6.3 ± 6.2 d for grade 2a and 15.8 ± 18.6 d for grade 2b. It was significantly longer for patients with grade 2a and 2b injuries (P = 0.000). CONCLUSION: Endoscopy is an effective technique for determining the presence of esophageal and gastric damage and to avoid unnecessary treatment in patients with no or mild injury. | Abdulkerim Temiz Pelin Oguzkurt Semire Serin Ezer Emine Ince Akgun Hicsonmez | 2012 | World Journal of Gastroenterology2012，18，10： | 8 |
| 3 | Diabetes-induced changes in cardiac voltage-gated ion channels显示文摘Diabetes mellitus affects the heart through various mechanisms such as microvascular defects,metabolic abnormalities,autonomic dysfunction and incompatible immune response.Furthermore,it can also cause functional and structural changes in the myocardium by a disease known as diabetic cardiomyopathy(DCM)in the absence of coronary artery disease.As DCM progresses it causes electrical remodeling of the heart,left ventricular dysfunction and heart failure.Electrophysiological changes in the diabetic heart contribute significantly to the incidence of arrhythmias and sudden cardiac death in diabetes mellitus patients.In recent studies,significant changes in repolarizing K+currents,Na+currents and L-type Ca^(2+)currents along with impaired Ca^(2+ )homeostasis and defective contractile function have been identified in the diabetic heart.In addition,insulin levels and other trophic factors change significantly to maintain the ionic channel expression in diabetic patients.There are many diagnostic tools and management options for DCM,but it is difficult to detect its development and to effectively prevent its progress.In this review,diabetes-associated alterations in voltage-sensitive cardiac ion channels are comprehensively assessed to understand their potential role in the pathophysiology and pathogenesis of DCM. | Nihal Ozturk Serkan Uslu Semir Ozdemir | 2021 | World Journal of Diabetes2021，12，1： | 6 |
| 4 | Trace elements in diabetic cardiomyopathy:An electrophysiological overview显示文摘There is a growing body of evidence that Diabetes Mellitus leads to a specific cardiomyopathy apart from vascular disease and bring about high morbidity and mortality throughout the world.Recent clinical and experimental studies have extensively demonstrated that this cardiomyopathy causes impaired cardiac performance manifested by early diastolic and late systolic dysfunction.This impaired cardiac performance most probably have emerged upon the expression and activity of regulatory proteins such as Na+/Ca2+exchanger,sarcoplasmic reticulum Ca2+-ATPase,ryanodine receptor and phospholamban.Over years many therapeutic strategies have been recommended for treatment of diabetic cardiomyopathy.Lately,inorganic elements have been suggested to have anti-diabetic effects due to their suggested ability to regulate glucose homeostasis,reduce oxidative stress or suppress phosphatases.Recent findings have shown that trace elements exert many biological effects including insulin-mimetic or antioxidant activity and in this manner they have been recommended as potential candidates for treatment of diabetes-induced cardiac complications,an effect based on their modes of action.Some of these trace elements are known to play an essential role as component of enzymes and thus modulate the organ function in physiological and pathological conditions.Besides,they can also manipulate redox state of the channels via antioxidant properties and thus contribute to the regulation of [Ca2+]i homeostasis and cardiac ion channels.On account of little information about some trace elements,we discussed the effect of vanadium,selenium,zinc and tungstate on diabetic heart complications. | Nihal Ozturk Yusuf Olgar Semir Ozdemir | 2013 | World Journal of Diabetes2013，4，4： | 2 |
| 5 | Effect of sodium tungstate on visual evoked potentials in diabetic rats显示文摘AIM: To evaluate the effect of sodium tungstate on visual evoked potentials(VEPs) in diabetic rats.· METHODS: Wistar rats were randomly divided into three groups as normal control, diabetic control and diabetic rats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin(50 mg/kg). Sodium tungstate [40 mg/(kg·d)]was administered for 12 wk and then VEPs were recorded.Additionally, thiobarbituric acid reactive substance(TBARS) levels were measured in brain tissues.·RESULTS: The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabetic rats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group.· CONCLUSION: Sodium tungstate shows protective effects on visual pathway in diabetic rats, and it can be worthy of further study for potential use. | Mehmet Bulut Bariszgür Dnmez Nihai ztürk Gksum Basaranlar Ceren Kencebay Manas Narin Derin Semir zdemir | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 2 |
| 6 | Non-invasive pressure support ventilation and CPAP in cardiogenic pulmonary edema:a multicenter randomized study in the emergency department显示文摘 | Semir Nouira Riadh Boukef Wahid Bouida | | 0，，02： | 1 |
| 7 | A simple solid injection device for the analyses of Bulbophyllum (Orchidaceae) volatiles 显示文摘 | da Silva U F Borba E L Semir J Marsaioli A J | 1999 | Phytochemistry1999，50，： | 1 |
| 8 | Self -incompatibility, inbreeding depression and crossing potential in five Brazilian Pleurothallis (Orchidaceae) species 显示文摘 | Borba E L Semir J Shepherd G J | 2001 | Ann Bot2001，88，： | 1 |
| 9 | Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast显示文摘 | Semir Vranic Caterina Marchiò Isabella Castellano Cristina Botta Maria Stella Scalzo Ryan P. Bender Cesar Payan-Gomez Ludovica Verdun di Cantogno Patrizia Gugliotta Fabrizio Tondat Paola Francia di Celle Sara Mariani Zoran Gatalica Anna Sapino | 2015 | Human Pathology2015，，9： | 1 |
| 10 | Reproductive systems and crossing potential in three species of Bulbophyllum (Orchidaceae)occurring in Brazilian'campo rupestre'vegetation显示文摘 | Borba EL Shepherd G J Semir J | 1999 | Plant Systematics anti Evolution1999，217，： | 1 |
| 11 | Primary vaginal calculus secondary to urethrovaginal fistula with imperforate hymen in a 6-year-old girl显示文摘 | Pelin Oguzkurt Emine Ince Semire Serin Ezer Abdülkerim Temiz Senay Demir Akgun Hicsonmez | 2009 | Journal of Pediatric Surgery2009，，7： | 1 |
| 12 | The efficacy of rituximab in patients with splenectomized refractory chronic idiopathic thrombocythopenic purpura显示文摘 | Semir Pasa Abdullah Altintas Timucin Cil Ramazan Danis Orhan Ayyildiz | 2009 | Journal of Thrombosis and Thrombolysis2009，，3： | 1 |
| 13 | Comparative transfection of DNA into primary and transformed mammalian cells from different lineages显示文摘 | Maurisse R De Semir D Emamekhoo H | 2010 | BMC Biotechnol2010，10，1： | 1 |
| 14 | Telomerase: going beyond the ends显示文摘 | De Semir D Nosmti M Li S | 2007 | Cell Cycle2007，6，5： | 1 |
| 15 | Lip anatomy and its implications for the pollination mechanisms of bulbophyllum species(Orchidaceae)显示文摘 | Teixeira Sde P Borba E L Semir J | 2004 | Ann Bot (Lond)2004，93，5： | 1 |
| 16 | 物联网时代:边缘计算与云计算的新融合显示文摘英国作家罗伯特·史蒂文生在其经典小说《化身博士》中,讲述了一个拥有双重人格的人物的故事:温文尔雅的杰基尔博士和邪恶且反社会的海德先生,如果只遇见其中一种人格,人们会把他们看作两个完全不同的人,但他们又确实是同一个人的两个面孔。在计算领域也是如此,人们可能看到的是两种相对立的方法 -边缘计算和云计算,它们都在解决物联网(IoT)中那些类似的问题. | Semir Haddad | 2018 | 中国电子商情2018，，10： | 1 |
| 17 | miRNA-205 suppresses mela- noma cell proliferation and induces senescence via regulation of E2F1 protein 显示文摘 | Dar AA Majid S de Semir D | 2011 | Biol Chem2011，286，16： | 1 |
| 18 | Lip anatomy and its implications for the pollination mechanisms of Bulbophyllum species( Orchidaceae) 显示文摘 | TEIXEIRA S D P BORBA E L SEMIR J | 2004 | Annals of Botany2004，93，： | 1 |
| 19 | miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein显示文摘 | Dar AA Majid S de Semir D | 2011 | J Biol Chem2011，286，16： | 1 |
| 20 | A simple solid injection device for the analyses of Bulbophyllum (Orchidaceae) volatiles显示文摘 | Da S U Borba E L Semir J Marsaioli A J | 1999 | Phytochemistry1999，50，1： | 1 |
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