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| 1 | 内侧固定平台单髁置换术后的冠状面下肢力线是翻修的影响因素显示文摘膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)后患者冠状面的下肢力线被认为是影响手术长期疗效的一个重要因素,但关于最佳的UKA术后下肢力线还没有形成明确共识。一些研究主张术后下肢力线应保持在中立位,而另一些研究认为即使术后下肢力线存在10°的内翻也可获得良好的临床效果。 | Sean E Slaven John P Cody Robert A Sershon Henry Ho Robert H Hopper Jr Kevin B Fricka 李亚坤(整理) 张民(整理) | 2020 | 实用骨科杂志2020，26，12： | 15 |
| 2 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 3 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 4 | Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds显示文摘Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been studied.Here, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization. | Zupeng Chen Evgeniya Vorobyeva Sharon Mitchell Edvin Fako Núria López Sean M.Collins Rowan K.Leary Paul A.Midgley Roland Hauert Javier Pérez-Ramírez | 2018 | National Science Review2018，5，5： | 4 |
| 5 | Mathematical Modeling in Social Network Analysis: Using TOPSIS to Find Node Influences in a Social Network显示文摘 | William P Fox Sean F. Everton | 2013 | Journal of Mathematics and System Science2013，3，10： | 4 |
| 6 | Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children显示文摘AIM To describe our institutional experience with conversion from intravenous(IV) fentanyl infusion directly to enteral methadone and occurrence of withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation and analgesia.METHODS With Institutional Review Board approval,we retrospectively studied consecutively admitted invasively mechanically ventilated children(0-18 years) sedated with IV fentanyl infusion > 5 d and subsequently converted directly to enteral methadone.Data were obtained onsubject demographics,illness severity,daily IV fentanyl and enteral methadone dosing,time to complete conversion,withdrawal scores(WAT-1),pain scores,and need for rescue opioids.Patients were classified as rapid conversion group(RCG) if completely converted ≤ 48 h and slow conversion group(SCG) if completely converted in > 48 h.Primary outcome was difference in WAT-1 scores at 7 d.Secondary outcomes included differences in overall pain scores,and differences in daily rescue opioids.RESULTS Compared to SCG(n = 21),RCG(n = 21) had lower median WAT-1 scores at 7 d(2.5 vs 5,P = 0.027).Additionally,RCG had lower overall median pain scores(3 vs 6,P = 0.007),and required less median daily rescue opioids(3 vs 12,P = 0.003) than SCG.The starting daily median methadone dose was 2.3 times the daily median fentanyl dose in the RCG,compared to 1.1 times in the SCG(P = 0.049).CONCLUSION We observed wide variation in conversion from IV fentanyl infusion directly to enteral methadone and variability in withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation.In those children who converted successfully from IV fentanyl infusion to enteral methadone within a period of 48 h,a methadone:fentanyl dose conversion ratio of approximately 2.5:1 was associated with less withdrawal and reduced need for rescue opioids. | Vijay Srinivasan Daniel Pung Sean P O'Neill | 2017 | World Journal of Clinical Pediatrics2017，6，2： | 3 |
| 7 | Plant recruitment and survival as indicators of ecological restoration success in abandoned pasture land in Nurcoung,Victoria,Australia显示文摘Introduction:One of the major impediments to developing better restoration strategies is the inadequate documentation of past restoration efforts.In 2008,Greening Australia commenced ecological restoration on the Nurcoung property in Victoria to enhance local biodiversity,and in this paper we report on the habitat restoration outcomes in the three Ecological Vegetation Classes(EVC)found on this property.Methods:Permanent sample plots(12×20 m)were randomly established in July 2010 in each of the restoration areas,with 9,10,and 24 plots demarcated in Shallow Sands Woodland(SSW),Heathy Woodland(HW),and Sandstone Ridge Woodlands(SRW),respectively.Individual plots were prepared to include three seeded rows.Plots were assessed for seedling recruitment and survival in May 2010,April 2011,and May 2012.Records of individual seedling development included their height and cover,and their location within the plot.Results:Our study shows that interaction between the age of the planted and direct-seeded vegetation and the nature of the EVC significantly affects the composition of plants and the soil surface in that species and,further,that soil cover parameters develop in different ways in the different experimental plots.A SIMPER analysis of soil cover parameters shows that most of the variation over the years of restoration is attributable to differences in the amount of bare soil recorded,rather than the amount of leaf-litter cover,and that these changes in soil cover parameters differ between EVCs over the sampling periods.The direct-seeding study shows that whilst most of the broadcast species were recruited,some species used in the Shallow Sands Woodland,the Heathy Woodland,and the Sandstone Ridge Shrubland did not show evidence of recruitment during the three sampling periods.Although the density of most seedlings increased in subsequent sampling years,the planted species Callitris gracilis,Callitris rhomboidea,Hakea muelleriana,and Melaleuca lanceolata did not survive.Conclusions:As a result of the land use change,new assemblages of abiotic and biotic system components appear to lead to the development of stable alternative ecological states.These‘novel’ecosystems now play an important part of the natural resource base,requiring careful characterization to better understand current development trajectories and future states,and to inform management strategies to meet desired restoration outcomes.Although the study sites have been abandoned for a long time,broadcast seeds and plant seedlings show they can overcome internal resilience. | Singarayer K Florentine Jessica Gardner Friedrich P Graz Sean Moloney | 2013 | Ecological Processes2013，2，1： | 2 |
| 8 | Use of sodium bicarbonate and blood gas monitoring in diabetic ketoacidosis: A review显示文摘Diabetic ketoacidosis(DKA) is a severe and toocommon complication of uncontrolled diabetes mellitus. Acidosis is one of the fundamental disruptions stemming from the disease process, the complications of which are potentially lethal. Hydration and insulin administration have been the cornerstones of DKA therapy; however, adjunctive treatments such as the use of sodium bicarbonate and protocols that include serial monitoring with blood gas analysis have been much more controversial. There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate. However, there is scant data to support or refute the role of bicarbonate therapy in very severe acidosis. Arterial blood gas(ABG) assessment is an element of some treatment protocols, including society guidelines, for DKA. We review the evidence supporting these recommendations. In addition, we review the data supporting some less cumbersome tests, including venous blood gas assessment and routine chemistries. It remains unclear that measurement of blood gas pH, via arterial or venous sampling, impacts management of the patient substantially enough to warrant the testing, especially if sodium bicarbonate administration is not being considered. There are special circumstances when serial ABG monitoring and/or sodium bicarbonate infusion are necessary, which we also review. Additional studies are needed to determine the utility of these interventions in patients with severe DKA and pH less than 7.0. | Mit P Patel Ali Ahmed Tharini Gunapalan Sean E Hesselbacher | 2018 | World Journal of Diabetes2018，9，11： | 2 |
| 9 | Albuterol and levalbuterol use and spending in medicare beneficiaries with chronic obstructive pulmonary disease显示文摘 | Andrea P Sean M Henry B | 2010 | Am J Geriat Pharmacother2010，8，6： | 1 |
| 10 | Carotid arteries:contrast-enhanced US angiography-preliminary clinical experience显示文摘 | Kono Y Sean P Claude B | | 0，，： | 1 |
| 11 | Hydraulic permeability of protein deposits formed during MF: Effect of solution pH and ionic strength显示文摘 | PALECEK Sean P | 1994 | J Membr Sci1994，95，： | 1 |
| 12 | Lower extremity joint kinetic responses to external resistance variations显示文摘 | Sean P F George J S | 2008 | J Appl Biomech2008，24，1： | 1 |
| 13 | Raman spectroscopy as a morphological probe for TiO2 aerogels 显示文摘 | Sean K Fred H P Micha T | 1997 | J Phys Chem B1997，101，14： | 1 |
| 14 | Talar neck fractures:results and outcomes显示文摘 | Heather A Sean E David P | 2004 | J Bone Joint Surg Am2004，86，8： | 1 |
| 15 | Preliminary investigation of constructed wetland incorporating microbial fuel cell: batch and continuous flow trials 显示文摘 | ZHAO Y SEAN C MARK P | 2013 | Chemical Engineering Journal2013，229，： | 1 |
| 16 | Is the Absence of an Ipsilateral Fibular Fracture Predictive of Increased Radiographic Tibial Pilon Fracture Severity?显示文摘 | David P Barei Sean E Nork Carlo Bellabarba Bruce J Sangeorzan | 2006 | Journal of Orthopaedic Trauma2006，，1： | 1 |
| 17 | Raman spectroscopy as a morphological probe for TiO2 aerogels显示文摘 | SEAN K FRED H P MICHA T | 1997 | J Phys Chem B1997，101，： | 1 |
| 18 | Mechanical performance of polyurethane ureteral stents in vitro and ex-vivo显示文摘 | Sean P Gorman David S Jones Michael C Bonner | 1997 | Biomaterals1997，18，： | 1 |
| 19 | Macrophages and Progressive tubulointerstitial disease 显示文摘 | Sean Eardley K Cockwell P | 2005 | Kidney Int2005，68，2： | 1 |
| 20 | Appropiate measures and consistent standard for high energy laser beam quality显示文摘 | SEAN K T LATHAM W P | 2006 | Journal of Directed Energy2006，2，： | 1 |
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