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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | Opposite effects of nitrogen fertilization and plastic film mulching on crop N and P stoichiometry in a temperate agroecosystem显示文摘Aims Crop nitrogen(N)and phosphorus(P)stoichiometry can influence food nutritive quality and many ecosystem processes.However,how and why N and P stoichiometry respond to long-term agricul-tural management practices(e.g.N fertilization and film mulching)are not clearly understood.Methods We collected maize tissues(leaf,stem,root and seed)and soil sam-ples from a temperate cropland under 30-year continuous N fer-tilization and plastic film mulching treatments,measured their C,N and P concentrations(the proportion(%)relative to the sample mass),and used structural equation models to uncover the re-sponding mechanisms for crop N and P contents(the total amount(g/m2)in crop biomass).Important Findings Long-term N fertilization increased N concentrations in all crop tissues but sharply decreased P concentrations in vegetative tis-sues(leaf,stem and root),thereby reducing their C/N ratio and increasing C/P and N/P ratios.The drop in P concentration in vegetative tissues was due to the dilution effect by biomass in-crement and the priority of P supply for seed production.In con-trast,film mulching decreased N concentration but increased P concentrations in most crop tissues,thereby increasing C/N ratio and reducing C/P and N/P ratios.Film mulching increased crop P content by increasing soil temperature and moisture;whereas,mulching showed little effect on crop N content,because a posi-tive effects of soil temperature may have canceled out a negative effect by soil moisture.This indicated a decoupling of P and N uptake by crops under film mulching.In conclusion,N fertiliza-tion and plastic film mulching showed opposite effects of on crop N and P stoichiometry. | Fan Ding Shuangyi Li Xiao-Tao Lü Feike A.Dijkstra Sean Schaeffer Tingting An Jiubo Pei Liangjie Sun Jingkuan Wang | 2019 | Journal of Plant Ecology2019，12，4： | 8 |
| 3 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 4 | Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds显示文摘Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been studied.Here, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization. | Zupeng Chen Evgeniya Vorobyeva Sharon Mitchell Edvin Fako Núria López Sean M.Collins Rowan K.Leary Paul A.Midgley Roland Hauert Javier Pérez-Ramírez | 2018 | National Science Review2018，5，5： | 4 |
| 5 | Initiator elements regulated expression or the herpes simplex virus thymidine kinase gene显示文摘 | JAMES C SEAN M L | 1995 | J Virol1995，69，11： | 1 |
| 6 | Relationship between oil exposure and reproductive parameters in fish collected following the Exxon Valdez oil spill显示文摘 | Sean Y S Lyndal L Johnson B H | 2000 | Marine Pollution Bulletin2000，12，40： | 1 |
| 7 | Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease:multicentre randomised controlled trail显示文摘 | GORDON K W SEAN L ELS G | 2000 | BMJ2000，321，： | 1 |
| 8 | Comparison of Clinical Efficacy and Safety of Three Professional At-Home Tooth Whitening Systems显示文摘 | Yiming Li Sean S Lee Susan L Cartwright | 2003 | Compendium2003，24，5： | 1 |
| 9 | Crowell cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by P21Cip1 and p27Kip1 in human pancreatic adenocarcinoma cells 显示文摘 | Dean AW Sean RW Pamela L | 2007 | Pharmacol Exp Ther2007，320，3： | 1 |
| 10 | A metagenomic survey of microbes in honey bee colony collapse disorder显示文摘 | Cox-Foster D L Sean C Holmes EC | 2007 | Science2007，318，5848： | 1 |
| 11 | Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor- I5 1 pathway显示文摘 | Thomas L Sean C Thomas C | 2008 | Am J Physiol Renal Physiol2008，295，1： | 1 |
| 12 | Mid-infrared spectroscopy of erbium doped chloride laser crystals 显示文摘 | Sean Kirkpatrick Shaw L Steven Bowman | 1997 | Optics Express1997，1，： | 1 |
| 13 | 显示文摘 | Sean L Willis Jane L Court | 2001 | Biomaterials2001，22，： | 1 |
| 14 | Early warning fire detection system using a probabilistic neural network显示文摘 | ROSE-PEHRSSON R SEAN J | 2003 | Fire Technology2003，，39： | 1 |
| 15 | Towards an Energy based Runoff Generation Theory for Tundra Landscapes显示文摘 | William L Quinton Sean K Carey | 2008 | Hydrological Processes2008，22，23： | 1 |
| 16 | Assessment of upper gastrointestinal safe- ty of etoricoxib and diclofenac in patients with osteoarthritis and rheuma- toid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long - term(MEDAL) programme : a randomised comparison 显示文摘 | Loren L Sean PC Byron C | 2007 | Lancet2007，369，9560： | 1 |
| 17 | Lower gastrointestinal events in a double - blind Trial of the cyclo - oxygenase - 2 selective inhibitor etoricoxib and the traditional nonsteroidal anti -inflammatory drug diclofenac 显示文摘 | Loren L Sean P Curti S | 2008 | Gas- troenterology2008，135，5： | 1 |
| 18 | The influence of 5,10-methylene tetrahydrofolate reductase genotypes on enzyme activity in placental tissue显示文摘 | Sean F Anne M James L | 1999 | Br J Obstet Gynecol1999，106，11： | 1 |
| 19 | Effect of H2 on the etch profile of InP/InGaAsP alloys in Cl2/Ar/H2 inductively coupled plasma reactive ion etching chemistries for photonic device fabrication 显示文摘 | Sean L Rommel Jae- Hyung Jang Wu Lu | 2002 | J Vac Sci Technol2002，20，4： | 1 |
| 20 | A synthe- tic route to size-controlled fcc and fct FePt nanoparticles显示文摘 | Luciano E M H Nguyen H L Sean R G | 2005 | Am Chem Soc2005，127，29： | 1 |
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