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| 1 | Controversies in fluid therapy: Type, dose and toxicity显示文摘Fluid therapy is perhaps the most common intervention received by acutely ill hospitalized patients; however, a number of critical questions on the efficacy and safety of the type and dose remain. In this review, recent insights derived from randomized trials in terms of fluid type, dose and toxicity are discussed. We contend that the prescription of fluid therapy is context-specific and that any fluid can be harmful if administered inappropriately. When contrasting ‘‘crystalloid vs colloid'', differences in efficacy are modest but differences in safety are significant. Differences in chloride load and strong ion difference across solutions appear to be clinically important. Phases of fluid therapy in acutely ill patients are recognized, including acute resuscitation, maintaining homeostasis, and recovery phases. Quantitative toxicity(fluid overload) is associated with adverse outcomes and can be mitigated when fluid therapy basedon functional hemodynamic parameters that predict volume responsiveness and minimization of non-essential fluid. Qualitative toxicity(fluid type), in particular for iatrogenic acute kidney injury and metabolic acidosis, remain a concern for synthetic colloids and isotonic saline, respectively. Physiologically balanced crystalloids may be the ‘‘default'' fluid for acutely ill patients and the role for colloids, in particular hydroxyethyl starch, is increasingly unclear. We contend the prescription of fluid therapy is analogous to the prescription of any drug used in critically ill patients. | Robert C McDermid Karthik Raghunathan Adam Romanovsky Andrew D Shaw Sean M Bagshaw | 2014 | World Journal of Critical Care Medicine2014，3，1： | 5 |
| 2 | 站立30s后直立性低血压与老年抑郁之间的纵向关系显示文摘直立性低血压(orthostatic hypotension,OH)与老年抑郁之间存在明确的横向联系。该观察性研究的目的是为了阐明基线症状性OH(symptomatic OH,sOH-30)与抑郁症之问的纵向关系。该样本包含无基线抑郁症的老年人(平均年龄62岁)〉3000名。 | Robert B Daniel C Sean PK Rose AK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 3 | Initiator elements regulated expression or the herpes simplex virus thymidine kinase gene显示文摘 | JAMES C SEAN M L | 1995 | J Virol1995，69，11： | 1 |
| 4 | Identifying West Nile virus risk areas:The dynamic continuous-area space-time system显示文摘 | Constandinos N Sean C Sue G | 2003 | Am J Epidemiology2003，157，： | 1 |
| 5 | Alteration of coagulation and fibrinolytic proteins in acute myocardial infarction and angina pec-toris显示文摘 | Sean C Kennedy | 2002 | Am J Med2002，90，3： | 1 |
| 6 | Unlocking the business outsourcing process model 显示文摘 | Sean M Handley W C Benton Jr | 2009 | Journal of Operations Management2009，27，5： | 1 |
| 7 | 二氧化碳地质储存计算的一种概率评价研究方法显示文摘1 前言
1.1目标和范围
2007年,能源独立和安全法案(公共法110-140)授权美国地质调查局(USGS)与美国环境保护局(EPA)和美国能源部(DOE)合作,实施一项二氧化碳(CO2)潜在的地质储存资源的国家评估。该活动的第一年,确定研制一种能统一用于全美国地层估算储存潜力的方法。 | Sean T Brennan Robert C .Burruss 何雪洲(翻译) | 2010 | 水文地质工程地质技术方法动态2010，，5： | 1 |
| 8 | Simulating time - varying cave flow and water levels using the Storm Water Management Model显示文摘 | C Warren Campbell Sean M Sullivan | 2002 | Engineering Geology2002，，65： | 1 |
| 9 | Spinal arteriovenous shunts presenting before 2 years of age : analysis of 13 cases 显示文摘 | Sean C Hortensia A Georges R | 2006 | Childs Nerv Syst2006，22，： | 1 |
| 10 | Automated Surface Inspection System显示文摘 | Badger J C Enright Sean T | 1996 | Iron and Steel Engineer1996，3，： | 1 |
| 11 | Diabetes and mortality follow- ing acute coronary syndromes 显示文摘 | Sean M Garrick C Carolyn H | 2007 | JAMA2007，298，7： | 1 |
| 12 | Magnesium reduces free radicals in a in vivo coronary occlusion reperfusion model显示文摘 | Lawrence A Steven C Sean M | 2008 | J Am Coil Cardiol2008，32，2： | 1 |
| 13 | Magnesium reduceds free radicals in a in vivo caranary occlasion reperfusion model 显示文摘 | Lawrence A Steven C Sean | 1998 | Am Coll Cardiol1998，32，2： | 1 |
| 14 | Cloud computing security 显示文摘 | SEAN C CURRAN K | 2011 | International Journal of Ambient Computing and Intelligence2011，3，1： | 1 |
| 15 | Variable optical attenuator for large- scale integration显示文摘 | SEAN M G STEVE C | 2002 | IEEE Photonics Technology Letters2002，14，11： | 1 |
| 16 | Stem cells,cancer,and cancer stem cells显示文摘 | Tannishtha Reya Sean J M Michael F C | 2001 | Nature2001，414，： | 1 |
| 17 | Transpiration of cottonwood/willow forest estimated from sap flux 显示文摘 | Sean M Schaeffer David G Williams David C Goodrich | 2000 | Agricultural and Forest Meteorology2000，105，： | 1 |
| 18 | Preliminary investigation of constructed wetland incorporating microbial fuel cell: batch and continuous flow trials 显示文摘 | ZHAO Y SEAN C MARK P | 2013 | Chemical Engineering Journal2013，229，： | 1 |
| 19 | Modeling visual attention via selective tuning 显示文摘 | TSOTSOS J K SEAN M C | 1995 | Artificial Intelligence1995，78，12： | 1 |
| 20 | A metagenomic survey of microbes in honey bee colony collapse disorder显示文摘 | Cox-Foster D L Sean C Holmes EC | 2007 | Science2007，318，5848： | 1 |
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