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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 3 | Understanding the adoption of multipurpose information appliances: The case of mobile data services显示文摘 | Se - Joon Hong Kar Yan Tam | 2006 | Information system research2006，17，2： | 1 |
| 4 | Effects of prenatal alcohol exposure on brain - derived neurotrophic factor and its receptor tyroxine kinase B in offspring显示文摘 | Feng M J Yah SE Yan Qs | 2005 | Brain Res2005，1042，20： | 1 |
| 5 | Effect s of prenatal alcohol exposure on brain-derived neurot -rophic factor and it s receptor tyrosine kinase B in offspring 显示文摘 | Feng MJ Yan SE Yan QS | 2005 | Brain Research2005，1042，2： | 1 |
| 6 | Response to smallpox vaccine in persons immunized in the distant past显示文摘 | Frey SE Newman FK Yan L | 2003 | JAMA2003，289，24： | 1 |
| 7 | Different expression of brain-derived neurotrophic factor in the nucleus accumbens of alcohol-preferring (p) and-nonpreferring (np) rats 显示文摘 | Yan QS Feng M J Yah SE | 2005 | Brain Res2005，1035，： | 1 |
| 8 | Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyrosine kinase B in offspring 显示文摘 | Feng M J Yan SE Yah QS | 2005 | Brain Res2005，1042，： | 1 |
| 9 | Hindbrain leptin and glucagonlike-peptide-1 receptor signaling interact to suppress food intake in an additive manner显示文摘 | Zhao S Kanoski SE Yan J | 2012 | Int J Obes2012，36，12： | 1 |
| 10 | Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyrosine kinase B in offspring 显示文摘 | Feng MJ Yan SE Yan QS | 2005 | Brain Res2005，1042，2： | 1 |
| 11 | Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis 显示文摘 | L1 Yan ZHANG SF Zou SE | 2011 | Reprod Biol Endocrinol2011，9，： | 1 |
| 12 | Decorin GAG synthesis and TGF-β signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells显示文摘 | Yan J Stringer SE Hamilton A | 2011 | Arterioscler Thromb Vasc Biol2011，31，3： | 1 |
| 13 | Differential susceptibility of heart,skin,and islet allografts to T cell-mediated rejection显示文摘 | Jones ND Turvey SE Yan Maurik A | 2001 | J Immunol2001，166，4： | 1 |
| 14 | Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyroxine kinase B in offspring显示文摘 | Feng MJ Yan SE Yan QS | 2005 | Brain Res2005，1042，2： | 1 |
| 15 | Fucoidan elevates Micro RNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocel ular carcinoma cells显示文摘 | Yan MD Yao CJ Chow JM Chang CL Hwang PA Chuang SE | 2015 | Mar Drugs2015，13，10： | 1 |
| 16 | Evaluation of peripheral nerve regeneration via in vivo serial transcutaneous imaging using transgenic Thy1-YFP mice显示文摘 | Yan Y Sun HH Mackinnon SE | | 0，，01： | 1 |
| 17 | Genetic factors for differentiated thyroid cancer in French Polynesia:new candidate loci显示文摘Background:Populations of French Polynesia(FP),where France performed atmospheric tests between 1966 and 1974,experience a high incidence of differentiated thyroid cancer(DTC).However,up to now,no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive conclusion.This research aimed to analyze the genetic factors of DTC risk among the native FP populations.Methods:We analyzed more than 300000 single nucleotide polymorphisms(SNPs)genotyped in 283 DTC cases and 418 matched controls born in FP,most being younger than 15 years old at the time of the first nuclear tests.We analyzed the genetic profile of our cohort to identify population subgroups.We then completed a genome-wide analysis study on the whole population.Results:We identified a specific genetic structure in the FP population reflecting admixture from Asian and European populations.We identified three regions associated with increased DTC risk at 6q24.3,10p12.2,and 17q21.32.The lead SNPs at these loci showed respective p-values of 1.66×10^(−7),2.39×10^(−7),and 7.19×10^(−7) and corresponding odds ratios of 2.02,1.89,and 2.37.Conclusion:Our study results suggest a role of the loci 6q24.3,10p12.2 and 17q21.32 in DTC risk.However,a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian population.Moreover,the functional impact of these three new loci needs to be further explored and validated. | Monia Zidane Marc Haber Thérèse Truong Frédérique Rachédi Catherine Ory Sylvie Chevillard Hélène Blanché Robert Olaso Anne Boland Éric Conte Mojgan Karimi Yan Ren Constance Xhaard Vincent Souchard Jacques Gardon Marc Taquet André Bouville Jean-François Deleuze Vladimir Drozdovitch Florent de Vathaire Jean-Baptiste Cazier | 2023 | Precision Clinical Medicine2023，6，2： | 0 |
| 18 | Aging–Passing the Baton to Asia显示文摘China current demographic trends One-child policy lowered the fertility rate China has experienced a transition from high to low birth rates since the 1970s,when the government began enforcing the one-child policy.Women were generally allowed to have only one child,and additional births were heavily fined.As a result,the fertility rate slumped to around 1.5recently from over two in 1980 and four in 1973(Figure 1)。 | Se Yan | 2017 | China's Foreign Trade2017，，4： | 0 |
| 19 | China——A Tougher Balancing Act in 2016显示文摘China’s economy can potentially grow at about 7% if capacity is adequately utilised.However,production capacity exceeds demand as a result of credit-driven over-investment in the past decade.Without demand-boosting policies,we estimate that the self-sustaining growth rate is currently 6%at most.The government faces a tougher balancing act in | Shuang Ding Se Yan Lan Shen Betty Rui Wang | 2016 | China's Foreign Trade2016，，1： | 0 |
| 20 | China-Price Guidelines Advance 'Deep Reforms'显示文摘·China commits to lifting price controls in competitive sectors by 2017 under new guidelines·Reforms focus on monopolistic sectors,public sector and heavily subsidised sectors·Price reforms send a strong signal of accelerating deep reformsMost remaining price controls to be lifted by 2017China recently announced a new round of pricing reforms and set a timetable for revamping the country’s pricing mechanism.Price controls for most goods and services in com- | Se Yan Shuang Ding | 2015 | China's Foreign Trade2015，，6： | 0 |
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