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| 1 | 全球溺水负担:GBD 2017全球疾病负担死亡率的估计研究显示文摘世界卫生组织已将溺水确定为公共卫生优先事项。溺水指因淹没或者浸没于液体中而出现呼吸障碍的过程,其结果分为死亡、受伤和不受伤。致命性溺水是世界范围内导致非故意伤害相关死亡的主要原因,全球每年约有30万人溺水死亡。中低收入国家非故意溺水发生尤为严重。此外,男性和儿童是非故意溺水的高危人群。伤害预防工作者掌握准确和及时的数据将有助于合理分配公共卫生资源和评价干预措施的效果。 | 黄锦裕 佘宇航(摘译) 李丽萍(审校) Franklin R C Peden A E Hamilton E B | 2020 | 伤害医学(电子版)2020，9，4： | 6 |
| 2 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
| 3 | 硬皮病的诊断与治疗显示文摘1 简介
1.1 背景知识:硬皮病的英文名称Scleroderma,是由希腊单词Skleros(硬的或硬结的)和Derma(皮肤)衍化而来的。希波格拉底首次用增厚的皮肤描述这种情形。CarloCurzio(1752年)遇到一名出现皮肤坚硬的患者时,第一次对这种情形进行了详细描述,即像木头或干燥的皮革一样。 | Serqio A Jimenez Dorrance H Hamilton | 2007 | 继续医学教育2007，21，23： | 4 |
| 4 | Reconstructing the Primordial Spectrum of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 3 |
| 5 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 6 | Antisense gene that inhibits synthesis of the hormone ethylene in transgenic plant 显示文摘 | Hamilton A J Yycett G W Grierson D | 1990 | Nature1990，346，： | 2 |
| 7 | Using individual tree growth projection models to estimate stand-level gains attributable to genetically improved stock显示文摘 | Hamilton D A Rehfeldt G E | 1994 | For Ecol Manage1994，68，： | 2 |
| 8 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 9 | Weighing the options in the pharmacotherapy of obesity 显示文摘 | Wieland H A Hamilton B S | 2001 | Int J Clin Pharmacol Therapeut2001，39，9： | 2 |
| 10 | Prevalence and clinical in plications of abnormal throid hormone metabolism in advanced heart failure显示文摘 | | 1993 | Annals of Thoracic Surgery1993，56，1： | 1 |
| 11 | Physical modeling of the step recovery diode for pulse and harmonic generation circuits显示文摘 | Moll J L Hamilton S A | 1969 | Proc of the IEEE1969，57，7： | 1 |
| 12 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois M Gilles K A Hamilton J K | 1956 | Anal Chem1956，28，： | 1 |
| 13 | Phytoremediation of soil contaminated with low concentrations of radionuclides显示文摘 | Entry J A Vance N C Hamilton M A | 1996 | Water Air Soil Pollution1996，88，： | 1 |
| 14 | Visual loss as a complication of spine surgery: A review of 37 cases 显示文摘 | Myers MA Hamilton SR Bogosian A J | 1997 | Spine1997，22，： | 1 |
| 15 | Measuring sustainable development:Progress on indicators 显示文摘 | Pearce D K Hamilton A | 1996 | Environmental and Development Economics1996，，1： | 1 |
| 16 | Antisense gene that inhibit synthesis of hormone ethylene in transgenic plants 显示文摘 | Hamilton A J Lyett G W Grierson D | 1990 | Nature1990，346，6281： | 1 |
| 17 | Melatonin for cashmere production in breeding does 显示文摘 | O'NEILL K LITHERLAND A J HAMILTON G | 1992 | Journal of Pineal Research1992，52，： | 1 |
| 18 | C-2 neurec-tomy during atlantoaxial instrumented fusion in the elderly: patient satisfaction and surgical outcome 显示文摘 | Hamilton D K Smith J S Sansur C A | 2011 | J Neurosurg Spine2011，15，1： | 1 |
| 19 | HER2:a predictive factor ready to use in the daily management of breast patients显示文摘 | Piccorf MJ Di Leo A Hamilton A | | 0，，： | 1 |
| 20 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
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