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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | 4例虹膜蔓状血管瘤光学相干体层成像术血管造影特征显示文摘血管畸形中失调的TGF-β/BMP信号通路
血管树正确的结构要求调控管腔形成,血管生长和重塑的信号通路激活并达到平衡。当这一平衡被打破时,会出现血管发育畸形。该文旨在回顾转化生长因子(TGF)-β、骨形成蛋白(BMP)信号通路在血管形成和发展中的作用。胚胎期灭活这些信号通路,将导致血管组织变异。 | Chien JL Sioufi K Ferenczy S Say EAT 张凌 Cunha SI Magnusson PU Dejana E | 2017 | 中国口腔颌面外科杂志2017，15，6： | 6 |
| 3 | 孑遗植物桫椤内生真菌的多样性与群落组成显示文摘桫椤为木本蕨类,在世界范围内属于濒危的孑遗植物,关于桫椤内生真菌的研究还未见报道。本文基于形态学特征和DNA序列分析技术,探讨了桫椤内生真菌多样性和群落组成。研究发现,桫椤组织中蕴藏着丰富的真菌资源,内生真菌定殖率达到87.6%;从桫椤的234个生活组织块中,分离到内生真菌291株,被鉴定为64个分类单元;桫椤组织中常见真菌种类大约占内生真菌的60%,其中铺散内曼菌Nemania diffusa表现出明显的分布优势;内生真菌总体多样性指数达到3.53的较高水平,并且表现出叶轴>根部>羽片>叶柄>茎皮的分布规律;分析不同组织中内生真菌的相似性系数和聚类结果,发现桫椤的组织性质影响内生真菌的组成和分布;根据物种累积曲线,现有的研究样本中超过80%的内生真菌已经被分离到,研究结果能够反映桫椤内生真菌的多样性和群落组成。通过分析桫椤的叶柄凋落物中真菌定殖率、丰度、多样性、相似性和真菌种类等特征性数值,表明凋落的桫椤组织中真菌的分布特征已经发生了明显改变。 | 臧威 Luke Saye Nenwon KRUA 沈赤 杜贞娜 孙翔 孙剑秋 傅建伟 | 2020 | 菌物学报2020，39，4： | 5 |
| 4 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 5 | Sorption of tylosin onto swine manure显示文摘 | Angela C. Kolz Say Kee Ong T.B. Moorman | 2005 | Chemosphere2005，，2： | 2 |
| 6 | Ion imprinted cryogel-based supermacroporous traps for selective separation of cerium(Ⅲ) in real samples显示文摘This study demonstrates the preparation and characterization of a novel ion imprinted cryogel which exhibits high affinity and selectivity towards Ce(Ⅲ) ions in aqueous solutions and bastnasite ore samples.2-Hydroxyethyl methacrylate(HEMA) and N-methacryloylamido antipyrine(MAAP) were used as functional monomers for the preparation of Ce(Ⅲ) imprinted cryogel. The effects of various factors such as initial Ce(Ⅲ) concentration, flow rate, pH, interaction time and ionic strength on the Ce(Ⅲ) binding to the prepared ion imprinted cryogels were also studied. The binding equilibrium for Ce(Ⅲ) is obtained in30 min at the flow rate of 0.5 mL/min. The maximum binding capacity of the prepared ion imprinted cryogel towards Ce(Ⅲ) is obtained as 36.58 mg/g at optimum conditions. The selectivity of the prepared ion imprinted cryogel towards Ce(Ⅲ) in the presence of other possible interfering lanthanide ions such as La(Ⅲ) and Nd(Ⅲ) were also performed. The obtained results showed that the prepared ion imprinted cryogel exhibits high selectivity and sensitivity towards Ce(Ⅲ) ions. The limit of detection(LOD) was found as 50 μg/L. | Rüstem Kecili brahim Dolak Berrin Ziyadanogullari Arzu Ersoz Ridvan Say | 2018 | Journal of Rare Earths2018，36，8： | 2 |
| 7 | 桌面游戏在中国显示文摘“在一个阴暗冰冷的迷宫里,一位夹着公文包的律师正试图避开可怕的僵尸找出唯一的出口。等等!他突然想到,在此之前,或许可以利用其他几位竞争者帮忙拖住僵尸的脚步?他们一位是唠叨不停的职业经理人、一位精于算计的书商。还有一条每周只休息1天的程序员败狗,相信僵尸不会挑捌晚餐生前是做什么的……” | Greg Say | 2010 | 大众软件2010，，13： | 2 |
| 8 | Biosorption of cadmium(Ⅱ), lead (Ⅱ)and copper (Ⅱ) with the filamentous fungus Phanerochaete chrysosporium 显示文摘 | Say R Denizli A Arica M Y | 2001 | Bioresource tech noloy2001，76，1： | 2 |
| 9 | Effect of pH on transport of Pb^(2+),Mn^(2+),Zn^(2+) and Ni^(2+) through lateritic soil: Column experiments and transport modeling显示文摘This study investigated the effects of pH on the transport of Pb 2+ , Mn 2+ , Zn 2+ and Ni 2+ through lateritic soil columns. Model results by fitting the symmetric breakthrough curves (BTCs) of bromide (Br ) with CXTFIT model suggested that physical non-equilibrium processes were absent in the columns. The heavy metal BTCs were, however, asymmetrical and exhibited a tailing phenomenon, indicating the presence of chemical non-equilibrium processes in the columns. The retardation factors of Pb 2+ were the largest of the four metal ions at both pH 4.0 (33.3) and pH 5.0 (35.4). The use of Langmuir isotherm parameters from batch studies with HYDRUS-1D did not predict the BTCs well. Rather the two-site model (TSM) described the heavy metal BTCs better than the equilibrium linear/nonlinear Langmuir model. The fraction of instantaneous sorption sites ( f ) of all four metal ions on the lateritic soil was consistently about 30%-44% of the total sorption sites. | Srilert Chotpantarat Say Kee Ong Chakkaphan Sutthirat Khemarath Osathaphan | 2011 | Journal of Environmental Sciences2011，23，4： | 2 |
| 10 | The Expropriation Game:Mi-nority Shareholders'Protection显示文摘 | | 2003 | Hong Kong Law Journal2003，，33： | 1 |
| 11 | Intensity-based optical fiber sensor for monitoring corrosion of aluminum alloys显示文摘 | Liao Yanbiao Tian Qian | 2005 | Applied Optics2005，44，27： | 1 |
| 12 | Meeting the challenges of HIV/AIDS in Southeast and East Asia显示文摘 | Nicola P Brenda SAY | 2005 | Asia Pacific Viewpoint2005，46，1： | 1 |
| 13 | An improved response surface method for the determination of failure probablity and importance measures 显示文摘 | Say G Manohar C S | 2004 | Struc- ture Safty2004，26，： | 1 |
| 14 | Technique of hand-assisted laparoscopic surgery显示文摘 | O'Reilly MJ Saye WB Mullins SG | 1996 | J Laparoendoscopic Surg1996，6，： | 1 |
| 15 | Functionaliza- tion density dependence of single-walled carbon nano- tubes cytotoxicity in vitro 显示文摘 | Sayes C M Liang F Hudson J L | 2006 | Toxicol Lett2006，161，2： | 1 |
| 16 | Systematic review and metaanalysis of middle cerebral artery Doppler to predict perinatal wellbeing显示文摘 | Morris RK Say R Robson SC | 2012 | Eur J Obstet Gynecol Reprod Biol2012，，： | 1 |
| 17 | Global causes of maternaldeath: a WHO systematic analysis显示文摘 | Say L Chou D Gemmill A | 2014 | Lancet Glob Health2014，2，6： | 1 |
| 18 | Spondylocostal dysplasia and neural tube defects显示文摘 | Giacoia GP Say B | 1991 | J Med Genet1991，28，1： | 1 |
| 19 | Current Approaches to Punctuation in Computational Linguistics显示文摘 | Say B Akman V | 1997 | Computers and the Humanities1997，30，6： | 1 |
| 20 | Sensing of corrosion on aluminum surfaces by use of metallic optical fiber显示文摘 | Liao Yanbiao Tian Qian | 2005 | Applied Optics2005，44，30： | 1 |
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