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1Lipid-lowering agents in the management of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in developed countries and is associated not only with increased risk for liver disease-related complications but also with higher cardiovascular morbidity. Accordingly, lipid-lowering agents are frequently considered in these patients to reduce cardiovascular risk. However, there have been concerns regarding the safety of these agents in patients with chronic liver diseases. In the present review, we discuss the safety of lipid-lowering agents in patients with NAFLD as well as their effects on both cardiovascular and liver disease in this population. Accumulating data suggest that statins are safe in patients with NAFLD and that they reduce the increased cardiovascular morbidity of this population. However, it is still unclear whether statins are also useful as a treatment for NAFLD per se, since there are very limited and conflicting data on their effects on liver histology. There is also very scarce evidence regarding the safety and efficacy of other lipid-lowering agents in patients with NAFLD. Randomized controlled studies are needed to evaluate the role of lipid-lowering agents and particularly statins for the prevention of both cardiovascular and liver disease-related complications in this high-risk population.Konstantinos Tziomalos 2014World Journal of Hepatology2014,6,10:5
2非酒精性脂肪性肝病与缺血性卒中显示文摘非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一种以肝内脂肪过度沉积为特征的慢性肝病。越来越多的证据表明,NAFLD是一种影响多种肝外器官的多系统疾病。最近研究表明,NAFLD可能与缺血性卒中发病风险、严重程度以及转归相关。文章对此进行了综述。付亿玲 李桂兰 王佳 李轶男 龚栓成 卢旭东 2023国际脑血管病杂志2023,31,8:0
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