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| 1 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 2 | Different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk HPV genotype显示文摘 | de Cremoux P de la Rochefordi e re A Savignoni A | 2009 | Int J Cancer2009，124，4： | 1 |
| 3 | Different outcome of invasive cervical cancer assoc iatedwith high-risk versus intermediate-risk HPV genotype 显示文摘 | de Cremoux P de la Roehefordiere A Savignoni k | 2009 | Int J Cancer2009，124，4： | 1 |
| 4 | Different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk HPV genotype 显示文摘 | de Cremoux P de la Rochefordiere A Savignoni A | 2009 | Int J Cancer2009，124，4： | 1 |
| 5 | Prognostic role of pregnancy occurring before or after treatment of early breast cancer patients aged <35 years: a GET(N)A Working Group analysis显示文摘 | LARGILLiER R SAVIGNONI A GLiGOROV J | 2009 | Cancer2009，115，22： | 1 |
| 6 | Different out- come of invasive cervical cancer associated with high-risk, versus inter- mediate-risk HPV genotype显示文摘 | de Cremonx P de la Rochefordiere A Savignoni A | 2009 | Int J Cancer2009，124，4： | 1 |
| 7 | Long-term prognostic perform- ance of Ki67 rate in early stage, pTl-pT2, pN0,invasive breast carci- noma显示文摘 | Reyal F Hajage D Savignoni A | 2013 | PLoS One2013，8，55： | 1 |
| 8 | Neuro-inflammatory risk factors treatment failure in 'early second stage' sleeping sickness patients treated with Pentamidine 显示文摘 | Lejon V Legros D Savignoni A | 2003 | Neuroimmunology2003，144，12： | 1 |
| 9 | Long-term prognostic per- formanee of Ki67 rate in early stage, pTl-pT2, pN0, invasive breast carcinoma显示文摘 | Reyal F Hajage D Savignoni A | 2013 | PLoS One2013，8，55： | 1 |
| 10 | Neuro-inflammatory risk factors treatment failure in 'early second stage' sleeping sickness patients treated with Pentamidine显示文摘 | Veerle Lejon Dominique Legros Alexia Savignoni | 2003 | Neuroimmunology2003，144，12： | 1 |
| 11 | A multicenter randomized phase II study of sequential epirubicin/cyclophosphamide followed by docetaxel with or without celecoxib or trastuzumab according to HER2 status, as primary chemotherapy for localized invasive breast cancer patients显示文摘 | Jean-Yves Pierga Suzette Delaloge Marc Espié Etienne Brain Brigitte Sigal-Zafrani Marie-Christine Mathieu Philippe Bertheau Jean Marc Guinebretière Marc Spielmann Alexia Savignoni Michel Marty | 2010 | Breast Cancer Research and Treatment2010，，2： | 1 |
| 12 | Management of inflammatory breast cancer after neoadjuvant chemotherapy显示文摘 | Abrous-Anane S Savignoni A Daveau C | 2011 | Int JRadiat Oncol Biol Phys2011，79，4： | 1 |
| 13 | The systemic systolic blood pressure of newborns with low weight 显示文摘 | Bucci G Scalarnandre A Savignoni PG | 1972 | Acta Paediatr Scand1972，，： | 1 |
| 14 | Dif- ferent outcome of invasive cervical cancer associated with big h~risk versus intermediat e-risk H PV genotype显示文摘 | de Cremoux P de la Rochef ordie A Savignoni A etal | 2009 | Int JCan- cer2009，124，77： | 1 |
| 15 | Different outcome of invasive cervical cancer associated with high - risk versus intermediate - riskHPV genotype 显示文摘 | de Cremoux P de la Rochefordiere A Savignoni A | 2009 | Int J Cancer2009，124，4： | 1 |
| 16 | Differ- ent outcome of invasive cervical cancer associated with high-risk versus intermediate-risk HPV genotype显示文摘 | de Cremoux P de la Rochefordi&e A Savignoni A | 2009 | Int J Cancer2009，124，4： | 1 |
| 17 | Different outcome of invasive cervical cancer associated with high -risk vers us intermediate - risk HPV genotype 显示文摘 | de Cremoux P de la Roche fordism A Savignoni A | 2009 | Int J Cancer2009，，124： | 1 |
| 18 | Functional resid- ual capacity (FRC) and lung clearance index (LCI) in me- chanically ventilated infants:application in the newborn with congenital diaphragmatic hernia (CDH)显示文摘 | Landolfo F Savignoni F Capolupo I et a/ | 2013 | J Pediatr Surg2013，48，7： | 1 |
| 19 | Pilot evaluation of a French interdisciplinary supportive care department显示文摘 | Brédart A Dolbeault S Savignoni A | | 0，，12： | 1 |
| 20 | Different outcome of invasive cervical cancer associated with high-risk versus in- termediate-risk HPV genotype 显示文摘 | Cremoux P Rochefordiere A Savignoni A | 2009 | Int J Cancer2009，124，： | 1 |
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